A novel marker integrating multiple genetic alterations better predicts platinum sensitivity in ovarian cancer than HRD score

A novel marker integrating multiple genetic alterations better predicts platinum sensitivity in ovarian cancer than HRD score

Introduction: Platinum-based chemotherapy is the first-line treatment strategy for ovarian cancer patients. The dismal prognosis of ovarian cancer was shown to be stringently associated with the heterogeneity of tumor cells in response to this therapy, therefore understanding platinum sensitivity in...

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Bibliographic Details
Main Authors: Fan Yang, Wei Wei, Ganghua Li, Qiongyu Lan, Xiwei Liu, Lin Gao, Chao Zhang, Jiangtao Fan, Jundong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Genetics
Subjects:
Pt-score
platinum sensitivity
platinum-based chemotherapy
HRD score
ovarian cancer
genetic features
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1240068/full

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