SETD1A‐mediated H3K4me3 methylation upregulates lncRNA HOXC‐AS3 and the binding of HOXC‐AS3 to EP300 and increases EP300 stability to suppress the ferroptosis of NSCLC cells

SETD1A‐mediated H3K4me3 methylation upregulates lncRNA HOXC‐AS3 and the binding of HOXC‐AS3 to EP300 and increases EP300 stability to suppress the ferroptosis of NSCLC cells

Abstract Background Histone methyltransferases are crucial regulators in non‐small cell lung cancer (NSCLC) development. This study explored the mechanism of histone methyltransferase SET domain containing 1A (SETD1A)‐mediated H3K4me2 methylation in NSCLC cell ferroptosis and provides novel targets...

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Bibliographic Details
Main Authors: Zhenliang Shi, Hao Zhang, Yimeng Shen, Sipei Zhang, Xun Zhang, Yijun Xu, Daqiang Sun
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Thoracic Cancer
Subjects:
ferroptosis
H3K4me3
lncRNA HOXC‐AS3
non‐small cell lung cancer
SETD1A
Online Access:https://doi.org/10.1111/1759-7714.15037

Internet

https://doi.org/10.1111/1759-7714.15037

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