Blood serotonin concentration in children with COVID-19
COVID-19 has a risk of thrombotic complications. Serotonin plays an important role in pathogenesis of thrombosis.Purpose. To evaluate level of serotonin and its metabolite in the blood of children with COVID-19.Methods. This study included 72 children aged 3 to 17 years. Of these, 43 patients (mean...
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2022-11-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/1718 |
| _version_ | 1797875106417999872 |
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| author | L. R. Khusnutdinova D. I. Sadykova R. R. Nigmatullina |
| author_facet | L. R. Khusnutdinova D. I. Sadykova R. R. Nigmatullina |
| author_sort | L. R. Khusnutdinova |
| collection | DOAJ |
| description | COVID-19 has a risk of thrombotic complications. Serotonin plays an important role in pathogenesis of thrombosis.Purpose. To evaluate level of serotonin and its metabolite in the blood of children with COVID-19.Methods. This study included 72 children aged 3 to 17 years. Of these, 43 patients (mean age 11.2 ± 4.8 years) diagnosed with COVID-19 without comorbidities made up the study group, 29 healthy children (mean age 11.8 ± 3.8 years) — the control group. Concentration of serotonin and its metabolite (5-HIAA) in the blood was determined using high performance liquid chromatography with electrochemical detection. Computed tomography data were used to determine severity of lung damage.Results. In our study children with COVID-19 aged 3 to 17 years had significantly higher serotonin and its metabolite levels compared to the control group. Concentration of serotonin in plasma in main group was 20–30 times higher than in the same-age control. The 5-HIAA/serotonin ratio in children with COVID-19 is significantly lower than in the control group. Levels of serotonin and 5-HIAA in children with COVID-19 depending on the severity of CT-scan lung damage showed no significant differences.Conclusion. Serotonin and its metabolite levels in plasma of children with COVID-19 is significantly increased. It may be related to platelet hyperactivation in SARS-CoV-2 infection and increased risk of thrombosis, which requires further research. |
| first_indexed | 2024-04-10T01:41:24Z |
| format | Article |
| id | doaj.art-6edd90a9da0b4c1c9c18ddd5b01bd34b |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:41:24Z |
| publishDate | 2022-11-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-6edd90a9da0b4c1c9c18ddd5b01bd34b2023-03-13T09:12:53ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282022-11-0167516316910.21508/1027-4065-2022-67-5-163-1691257Blood serotonin concentration in children with COVID-19L. R. Khusnutdinova0D. I. Sadykova1R. R. Nigmatullina2ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииCOVID-19 has a risk of thrombotic complications. Serotonin plays an important role in pathogenesis of thrombosis.Purpose. To evaluate level of serotonin and its metabolite in the blood of children with COVID-19.Methods. This study included 72 children aged 3 to 17 years. Of these, 43 patients (mean age 11.2 ± 4.8 years) diagnosed with COVID-19 without comorbidities made up the study group, 29 healthy children (mean age 11.8 ± 3.8 years) — the control group. Concentration of serotonin and its metabolite (5-HIAA) in the blood was determined using high performance liquid chromatography with electrochemical detection. Computed tomography data were used to determine severity of lung damage.Results. In our study children with COVID-19 aged 3 to 17 years had significantly higher serotonin and its metabolite levels compared to the control group. Concentration of serotonin in plasma in main group was 20–30 times higher than in the same-age control. The 5-HIAA/serotonin ratio in children with COVID-19 is significantly lower than in the control group. Levels of serotonin and 5-HIAA in children with COVID-19 depending on the severity of CT-scan lung damage showed no significant differences.Conclusion. Serotonin and its metabolite levels in plasma of children with COVID-19 is significantly increased. It may be related to platelet hyperactivation in SARS-CoV-2 infection and increased risk of thrombosis, which requires further research.https://www.ped-perinatology.ru/jour/article/view/1718детисеротонинcovid-195-гиук |
| spellingShingle | L. R. Khusnutdinova D. I. Sadykova R. R. Nigmatullina Blood serotonin concentration in children with COVID-19 Rossijskij Vestnik Perinatologii i Pediatrii дети серотонин covid-19 5-гиук |
| title | Blood serotonin concentration in children with COVID-19 |
| title_full | Blood serotonin concentration in children with COVID-19 |
| title_fullStr | Blood serotonin concentration in children with COVID-19 |
| title_full_unstemmed | Blood serotonin concentration in children with COVID-19 |
| title_short | Blood serotonin concentration in children with COVID-19 |
| title_sort | blood serotonin concentration in children with covid 19 |
| topic | дети серотонин covid-19 5-гиук |
| url | https://www.ped-perinatology.ru/jour/article/view/1718 |
| work_keys_str_mv | AT lrkhusnutdinova bloodserotoninconcentrationinchildrenwithcovid19 AT disadykova bloodserotoninconcentrationinchildrenwithcovid19 AT rrnigmatullina bloodserotoninconcentrationinchildrenwithcovid19 |