YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2

YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2

Abstract Background Ocular neovascularization is a leading cause of blindness. Retinal microglia have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the underlying mechanisms are not entirely clear. Lactylation is a novel lactate-derived posttranslational modification that pla...

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Bibliographic Details
Main Authors: Xiaotang Wang, Wei Fan, Na Li, Yan Ma, Mudi Yao, Guoqing Wang, Siyuan He, Wanqian Li, Jun Tan, Qi Lu, Shengping Hou
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Genome Biology
Subjects:
Angiogenesis
Retinal microglia
Posttranslational modifications (PTMs)
Lactylation
YY1
Online Access:https://doi.org/10.1186/s13059-023-02931-y

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