The end of the reign of a “master regulator’’? A defect in function of the LasR quorum sensing regulator is a common feature of Pseudomonas aeruginosa isolates

The end of the reign of a “master regulator’’? A defect in function of the LasR quorum sensing regulator is a common feature of Pseudomonas aeruginosa isolates

ABSTRACT Pseudomonas aeruginosa, a bacterium causing infections in immunocompromised individuals, regulates several of its virulence functions using three interlinked quorum sensing (QS) systems (las, rhl, and pqs). Despite its presumed importance in regulating virulence, dysfunction of the las syst...

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Bibliographic Details
Main Authors: Mylène C. Trottier, Thays de Oliveira Pereira, Marie-Christine Groleau, Lucas R. Hoffman, Ajai A. Dandekar, Eric Déziel
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:mBio
Subjects:
quorum sensing
Pseudomonas aeruginosa
virulence regulation
ecology
adaptive mutations
opportunistic infections
Online Access:https://journals.asm.org/doi/10.1128/mbio.02376-23

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