The effect of extract purple sweet drop on nuclear factor kappa B and amyloid deposits in D-galactose induced dementia in rats
Background. Alzheimer’s dementia (AD) as a neurodegenerative disease requires preventive measures to reduce its progression. Beta amyloid plaques induce chronic inflammation and apoptosis in AD. Anthocyanins in purple sweet potato are potential for prevention and therapy of AD. Aim. This study aime...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2021-12-01
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| Series: | Romanian Journal of Neurology |
| Subjects: | |
| Online Access: | https://rjn.com.ro/articles/2021.4/RJN_2021_4_Art-14.pdf |
| _version_ | 1811246753452654592 |
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| author | Ketut Widyastuti Anak Agung Ayu Putri Laksmidewi I Made Oka Adnyana |
| author_facet | Ketut Widyastuti Anak Agung Ayu Putri Laksmidewi I Made Oka Adnyana |
| author_sort | Ketut Widyastuti |
| collection | DOAJ |
| description | Background. Alzheimer’s dementia (AD) as a neurodegenerative disease requires preventive measures to reduce its progression. Beta amyloid plaques induce chronic inflammation and apoptosis in AD. Anthocyanins in purple sweet potato are potential for prevention and therapy of AD.
Aim. This study aimed to determine the role of anthocyanins in purple sweet potato extract to prevent inflammation so as to provide a neuroprotective effect on D-galactose-induced rats.
Material and methods. We used a randomized posttest only control group design. 32 male Wistar rats according to eligibility criteria were randomized into control and treatment groups. The treatment group was given purple sweet potato extract at a dose of 200mg/kgBW every day for 70 days. Both groups on day 15 induced dementia using D-galactose. Anti-inflammatory activity was evaluated from the examination of NFkB levels by ELISA technique and neuroprotective effects by immunohistochemical examination of amyloid plaque deposits.
Results. The mean NFkB of the treatment group (1417.55+255.82) was lower than the control group (1672.23+202.80) which was significant (p<0.05) and the amyloid plaque deposits in the treatment group were thinner than the control group. control.
Conclusions. Administration of purple sweet potato extract to D-galactose-induced rats caused lower NFkB levels and thinner amyloid plaque deposits. The research implication is that administration of purple sweet potato extract can prevent inflammation and provide neuroprotection effects in D-galactose-induced rats. |
| first_indexed | 2024-04-12T14:58:00Z |
| format | Article |
| id | doaj.art-6ee04f8bbb304735b2fcc9a89f3b5e89 |
| institution | Directory Open Access Journal |
| issn | 1843-8148 2069-6094 |
| language | English |
| last_indexed | 2024-04-12T14:58:00Z |
| publishDate | 2021-12-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj.art-6ee04f8bbb304735b2fcc9a89f3b5e892022-12-22T03:28:10ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942021-12-0120448548910.37897/RJN.2021.4.14The effect of extract purple sweet drop on nuclear factor kappa B and amyloid deposits in D-galactose induced dementia in rats Ketut Widyastuti0Anak Agung Ayu Putri Laksmidewi1I Made Oka Adnyana2Deparment of Neurology, Udayana University/Sanglah Hospital, Denpasar, Bali, Indonesia Deparment of Neurology, Udayana University/Sanglah Hospital, Denpasar, Bali, Indonesia Deparment of Neurology, Udayana University/Sanglah Hospital, Denpasar, Bali, IndonesiaBackground. Alzheimer’s dementia (AD) as a neurodegenerative disease requires preventive measures to reduce its progression. Beta amyloid plaques induce chronic inflammation and apoptosis in AD. Anthocyanins in purple sweet potato are potential for prevention and therapy of AD. Aim. This study aimed to determine the role of anthocyanins in purple sweet potato extract to prevent inflammation so as to provide a neuroprotective effect on D-galactose-induced rats. Material and methods. We used a randomized posttest only control group design. 32 male Wistar rats according to eligibility criteria were randomized into control and treatment groups. The treatment group was given purple sweet potato extract at a dose of 200mg/kgBW every day for 70 days. Both groups on day 15 induced dementia using D-galactose. Anti-inflammatory activity was evaluated from the examination of NFkB levels by ELISA technique and neuroprotective effects by immunohistochemical examination of amyloid plaque deposits. Results. The mean NFkB of the treatment group (1417.55+255.82) was lower than the control group (1672.23+202.80) which was significant (p<0.05) and the amyloid plaque deposits in the treatment group were thinner than the control group. control. Conclusions. Administration of purple sweet potato extract to D-galactose-induced rats caused lower NFkB levels and thinner amyloid plaque deposits. The research implication is that administration of purple sweet potato extract can prevent inflammation and provide neuroprotection effects in D-galactose-induced rats.https://rjn.com.ro/articles/2021.4/RJN_2021_4_Art-14.pdfanthocyaninsamyloid plaquenfkbpurple sweet potato |
| spellingShingle | Ketut Widyastuti Anak Agung Ayu Putri Laksmidewi I Made Oka Adnyana The effect of extract purple sweet drop on nuclear factor kappa B and amyloid deposits in D-galactose induced dementia in rats Romanian Journal of Neurology anthocyanins amyloid plaque nfkb purple sweet potato |
| title | The effect of extract purple sweet drop on nuclear factor kappa B and amyloid deposits in D-galactose induced dementia in rats |
| title_full | The effect of extract purple sweet drop on nuclear factor kappa B and amyloid deposits in D-galactose induced dementia in rats |
| title_fullStr | The effect of extract purple sweet drop on nuclear factor kappa B and amyloid deposits in D-galactose induced dementia in rats |
| title_full_unstemmed | The effect of extract purple sweet drop on nuclear factor kappa B and amyloid deposits in D-galactose induced dementia in rats |
| title_short | The effect of extract purple sweet drop on nuclear factor kappa B and amyloid deposits in D-galactose induced dementia in rats |
| title_sort | effect of extract purple sweet drop on nuclear factor kappa b and amyloid deposits in d galactose induced dementia in rats |
| topic | anthocyanins amyloid plaque nfkb purple sweet potato |
| url | https://rjn.com.ro/articles/2021.4/RJN_2021_4_Art-14.pdf |
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