Biocompatibility and Hemolytic Activity Studies of Synthesized Alginate-Based Polyurethanes
Many investigators have focused on the development of biocompatible polyurethanes by chemical reaction of functional groups contained in a spacer and introduced in the PU backbone or by a grafting method on graft polymerization of functional groups. In this study, alginate-based polyurethane (PU) co...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/10/2091 |
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| author | Kashif Zafar Khalid Mahmood Zia Rami M. Alzhrani Atiah H. Almalki Sameer Alshehri |
| author_facet | Kashif Zafar Khalid Mahmood Zia Rami M. Alzhrani Atiah H. Almalki Sameer Alshehri |
| author_sort | Kashif Zafar |
| collection | DOAJ |
| description | Many investigators have focused on the development of biocompatible polyurethanes by chemical reaction of functional groups contained in a spacer and introduced in the PU backbone or by a grafting method on graft polymerization of functional groups. In this study, alginate-based polyurethane (PU) composites were synthesized via step-growth polymerization by the reaction of hydroxyl-terminated polybutadiene (HTPB) and hexamethylene diisocyanate (HMDI). The polymer chains were further extended with blends of 1,4-butanediol (1,4-BDO) and alginate (ALG) with different mole ratios. The structures of the prepared PU samples were elucidated with FTIR and <sup>1</sup>H NMR spectroscopy. The crystallinity of the prepared samples was evaluated with the help of X-ray diffraction (XRD). The XRD results reveal that the crystallinity of the PU samples increases when the concentration of alginate increases. Thermogravimetric (TGA) results show that samples containing a higher amount of alginate possess higher thermal stability. ALG-based PU composite samples show more biocompatibility and less hemolytic activity. Mechanical properties, contact angle, and water absorption (%) were also greatly affected. |
| first_indexed | 2024-03-10T03:00:49Z |
| format | Article |
| id | doaj.art-6ee0aab4cba34ecb97bcc8c6fdcc5de0 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T03:00:49Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-6ee0aab4cba34ecb97bcc8c6fdcc5de02023-11-23T12:47:18ZengMDPI AGPolymers2073-43602022-05-011410209110.3390/polym14102091Biocompatibility and Hemolytic Activity Studies of Synthesized Alginate-Based PolyurethanesKashif Zafar0Khalid Mahmood Zia1Rami M. Alzhrani2Atiah H. Almalki3Sameer Alshehri4Department of Applied Chemistry, Government College University, Faisalabad 38030, PakistanDepartment of Applied Chemistry, Government College University, Faisalabad 38030, PakistanDepartment of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaDepartment of Pharmaceutical Chemistry, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaDepartment of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaMany investigators have focused on the development of biocompatible polyurethanes by chemical reaction of functional groups contained in a spacer and introduced in the PU backbone or by a grafting method on graft polymerization of functional groups. In this study, alginate-based polyurethane (PU) composites were synthesized via step-growth polymerization by the reaction of hydroxyl-terminated polybutadiene (HTPB) and hexamethylene diisocyanate (HMDI). The polymer chains were further extended with blends of 1,4-butanediol (1,4-BDO) and alginate (ALG) with different mole ratios. The structures of the prepared PU samples were elucidated with FTIR and <sup>1</sup>H NMR spectroscopy. The crystallinity of the prepared samples was evaluated with the help of X-ray diffraction (XRD). The XRD results reveal that the crystallinity of the PU samples increases when the concentration of alginate increases. Thermogravimetric (TGA) results show that samples containing a higher amount of alginate possess higher thermal stability. ALG-based PU composite samples show more biocompatibility and less hemolytic activity. Mechanical properties, contact angle, and water absorption (%) were also greatly affected.https://www.mdpi.com/2073-4360/14/10/2091biopolymerpolyurethane compositesalginate |
| spellingShingle | Kashif Zafar Khalid Mahmood Zia Rami M. Alzhrani Atiah H. Almalki Sameer Alshehri Biocompatibility and Hemolytic Activity Studies of Synthesized Alginate-Based Polyurethanes Polymers biopolymer polyurethane composites alginate |
| title | Biocompatibility and Hemolytic Activity Studies of Synthesized Alginate-Based Polyurethanes |
| title_full | Biocompatibility and Hemolytic Activity Studies of Synthesized Alginate-Based Polyurethanes |
| title_fullStr | Biocompatibility and Hemolytic Activity Studies of Synthesized Alginate-Based Polyurethanes |
| title_full_unstemmed | Biocompatibility and Hemolytic Activity Studies of Synthesized Alginate-Based Polyurethanes |
| title_short | Biocompatibility and Hemolytic Activity Studies of Synthesized Alginate-Based Polyurethanes |
| title_sort | biocompatibility and hemolytic activity studies of synthesized alginate based polyurethanes |
| topic | biopolymer polyurethane composites alginate |
| url | https://www.mdpi.com/2073-4360/14/10/2091 |
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