Cholesterol affects the relationship between albumin and major adverse cardiac events in patients with coronary artery disease: a secondary analysis
Abstract We aimed to examine whether the efficacy of the risk of poor prognosis in patients with coronary artery disease is jointly affected by total cholesterol and baseline serum albumin in a secondary analysis of previous study. We analyzed the data of 204 patients from October 2014 to October 20...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-16963-0 |
| _version_ | 1818018691548184576 |
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| author | Yu-Feng Yao Zhen-Yu Chen Tian-Yi Luo Xiao-Yan Dou Hai-Bo Chen |
| author_facet | Yu-Feng Yao Zhen-Yu Chen Tian-Yi Luo Xiao-Yan Dou Hai-Bo Chen |
| author_sort | Yu-Feng Yao |
| collection | DOAJ |
| description | Abstract We aimed to examine whether the efficacy of the risk of poor prognosis in patients with coronary artery disease is jointly affected by total cholesterol and baseline serum albumin in a secondary analysis of previous study. We analyzed the data of 204 patients from October 2014 to October 2017 for newly diagnosed stable CAD. The outcome was major adverse cardiac events (MACE; defined as all cause mortality, non fatal myocardial infarction, and non fatal stroke). The median duration of follow-up was 783 days. Multivariable COX model was performed to revalidate the relationship between the sALB and MACE and interaction tests were conducted to find the effects of total cholesterol on their association. A total of 28 MACE occurred among the 204 participants. The risk of MACE varied by baseline serum albumin and total cholesterol. Specifically, lower serum albumin indicated higher risk of MACE (HR 3.52, 95% CI 1.30–9.54), and a test for interaction between baseline serum albumin and total cholesterol on MACE was significant (P = 0.0005). We suggested that baseline serum albumin and total cholesterol could interactively affect the risk of poor prognosis of patients with coronary artery diseases. Our findings need to be confirmed by further randomized trials. |
| first_indexed | 2024-04-14T07:43:26Z |
| format | Article |
| id | doaj.art-6ee5ede8984e4b0a950e7d66435c3775 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-14T07:43:26Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6ee5ede8984e4b0a950e7d66435c37752022-12-22T02:05:25ZengNature PortfolioScientific Reports2045-23222022-07-011211610.1038/s41598-022-16963-0Cholesterol affects the relationship between albumin and major adverse cardiac events in patients with coronary artery disease: a secondary analysisYu-Feng Yao0Zhen-Yu Chen1Tian-Yi Luo2Xiao-Yan Dou3Hai-Bo Chen4Department of Ophthalmology, Shenzhen Second People’s HospitalDepartment of Cardiovascular Medicine, Shenzhen Second People’s HospitalDepartment of Ophthalmology, Shenzhen Second People’s HospitalDepartment of Ophthalmology, Shenzhen Second People’s HospitalDepartment of Cardiovascular Medicine, Shenzhen Second People’s HospitalAbstract We aimed to examine whether the efficacy of the risk of poor prognosis in patients with coronary artery disease is jointly affected by total cholesterol and baseline serum albumin in a secondary analysis of previous study. We analyzed the data of 204 patients from October 2014 to October 2017 for newly diagnosed stable CAD. The outcome was major adverse cardiac events (MACE; defined as all cause mortality, non fatal myocardial infarction, and non fatal stroke). The median duration of follow-up was 783 days. Multivariable COX model was performed to revalidate the relationship between the sALB and MACE and interaction tests were conducted to find the effects of total cholesterol on their association. A total of 28 MACE occurred among the 204 participants. The risk of MACE varied by baseline serum albumin and total cholesterol. Specifically, lower serum albumin indicated higher risk of MACE (HR 3.52, 95% CI 1.30–9.54), and a test for interaction between baseline serum albumin and total cholesterol on MACE was significant (P = 0.0005). We suggested that baseline serum albumin and total cholesterol could interactively affect the risk of poor prognosis of patients with coronary artery diseases. Our findings need to be confirmed by further randomized trials.https://doi.org/10.1038/s41598-022-16963-0 |
| spellingShingle | Yu-Feng Yao Zhen-Yu Chen Tian-Yi Luo Xiao-Yan Dou Hai-Bo Chen Cholesterol affects the relationship between albumin and major adverse cardiac events in patients with coronary artery disease: a secondary analysis Scientific Reports |
| title | Cholesterol affects the relationship between albumin and major adverse cardiac events in patients with coronary artery disease: a secondary analysis |
| title_full | Cholesterol affects the relationship between albumin and major adverse cardiac events in patients with coronary artery disease: a secondary analysis |
| title_fullStr | Cholesterol affects the relationship between albumin and major adverse cardiac events in patients with coronary artery disease: a secondary analysis |
| title_full_unstemmed | Cholesterol affects the relationship between albumin and major adverse cardiac events in patients with coronary artery disease: a secondary analysis |
| title_short | Cholesterol affects the relationship between albumin and major adverse cardiac events in patients with coronary artery disease: a secondary analysis |
| title_sort | cholesterol affects the relationship between albumin and major adverse cardiac events in patients with coronary artery disease a secondary analysis |
| url | https://doi.org/10.1038/s41598-022-16963-0 |
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