AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis
Energy stress activates AMPK leading to metabolic plasticity and therapy resistance in cancer. Here, the authors show that AMPK activation decreases Prospero-related homeobox 1 (PROX1) levels impairing branched amino acid metabolism and tumourigenesis in liver and lung cancer models.
Bibliographic Details
| Main Authors: |
Yanan Wang,
Mengjun Luo,
Fan Wang,
Yu Tong,
Linfeng Li,
Yu Shu,
Ke Qiao,
Lei Zhang,
Guoquan Yan,
Jing Liu,
Hongbin Ji,
Youhua Xie,
Yonglong Zhang,
Wei-Qiang Gao,
Yanfeng Liu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-34747-y
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