miRNA, Biogenesis and Mechanisms of Regulations
miRNAs(microRNAs) were discovered in 1993 in Caenorhabditis elegans as one of the most important gene expression regulatory factors. This regulatory role includes many of the important intracellular processes like genesis, differentiation, proliferation and apoptosis. miRNAs are among mRNAs and like...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2014-10-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/3977 |
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| author | Naeim Ehtesham Mahdiyeh Modi Majid Kheirollahi |
| author_facet | Naeim Ehtesham Mahdiyeh Modi Majid Kheirollahi |
| author_sort | Naeim Ehtesham |
| collection | DOAJ |
| description | miRNAs(microRNAs) were discovered in 1993 in Caenorhabditis elegans as one of the most important gene expression regulatory factors. This regulatory role includes many of the important intracellular processes like genesis, differentiation, proliferation and apoptosis. miRNAs are among mRNAs and like them are transcribed by RNA polymerase II and then cap and polyA tail are added to them. The resulted pri-miRNA converts to mature miRNA by two sequential trimming reactions. miRNAs exerts their regulatory effects by translation repression, translation activation and mRNA degradation. miRNAshave an important role in regulation of immune and nervous systems and disorder in their expression can lead to separate disease in both systems. |
| first_indexed | 2024-03-12T09:12:54Z |
| format | Article |
| id | doaj.art-6ee8b585358b4e538127a2fb1912b96e |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T09:12:54Z |
| publishDate | 2014-10-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-6ee8b585358b4e538127a2fb1912b96e2023-09-02T14:53:28ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2014-10-0132296125912681671miRNA, Biogenesis and Mechanisms of RegulationsNaeim Ehtesham0Mahdiyeh Modi1Majid Kheirollahi2MSc Student, Pediatric Inherited Diseases Research Center, Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranMSc Student, Pediatric Inherited Diseases Research Center, Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Pediatric Inherited Diseases Research Center, Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranmiRNAs(microRNAs) were discovered in 1993 in Caenorhabditis elegans as one of the most important gene expression regulatory factors. This regulatory role includes many of the important intracellular processes like genesis, differentiation, proliferation and apoptosis. miRNAs are among mRNAs and like them are transcribed by RNA polymerase II and then cap and polyA tail are added to them. The resulted pri-miRNA converts to mature miRNA by two sequential trimming reactions. miRNAs exerts their regulatory effects by translation repression, translation activation and mRNA degradation. miRNAshave an important role in regulation of immune and nervous systems and disorder in their expression can lead to separate disease in both systems.http://jims.mui.ac.ir/index.php/jims/article/view/3977miRNABiogenesisRegulations mechanism |
| spellingShingle | Naeim Ehtesham Mahdiyeh Modi Majid Kheirollahi miRNA, Biogenesis and Mechanisms of Regulations مجله دانشکده پزشکی اصفهان miRNA Biogenesis Regulations mechanism |
| title | miRNA, Biogenesis and Mechanisms of Regulations |
| title_full | miRNA, Biogenesis and Mechanisms of Regulations |
| title_fullStr | miRNA, Biogenesis and Mechanisms of Regulations |
| title_full_unstemmed | miRNA, Biogenesis and Mechanisms of Regulations |
| title_short | miRNA, Biogenesis and Mechanisms of Regulations |
| title_sort | mirna biogenesis and mechanisms of regulations |
| topic | miRNA Biogenesis Regulations mechanism |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/3977 |
| work_keys_str_mv | AT naeimehtesham mirnabiogenesisandmechanismsofregulations AT mahdiyehmodi mirnabiogenesisandmechanismsofregulations AT majidkheirollahi mirnabiogenesisandmechanismsofregulations |