Delayed-onset chest infections in liver transplant recipients: a prospective study
Abstract Objectives Liver transplant recipients are liable to many infectious and noninfectious chest complications, especially post-transplant pneumonia, which is the major cause of morbidity and mortality. Many studies have evaluated post-liver-transplant early-onset pneumonia. The aim of this stu...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2016-06-01
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| Series: | The Egyptian Journal of Bronchology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.4103/1687-8426.184362 |
| _version_ | 1818971081107570688 |
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| author | Mohammad Khairy El-Badrawy Raed El-Metwaly Ali Amr Mohamad Yassen Mohammad Ahmad Abou Elela Rehab Ahmad Elmorsey |
| author_facet | Mohammad Khairy El-Badrawy Raed El-Metwaly Ali Amr Mohamad Yassen Mohammad Ahmad Abou Elela Rehab Ahmad Elmorsey |
| author_sort | Mohammad Khairy El-Badrawy |
| collection | DOAJ |
| description | Abstract Objectives Liver transplant recipients are liable to many infectious and noninfectious chest complications, especially post-transplant pneumonia, which is the major cause of morbidity and mortality. Many studies have evaluated post-liver-transplant early-onset pneumonia. The aim of this study was to evaluate delayed-onset chest infections following liver transplantation. Materials and methods This prospective study was carried out on 50 adult living donor liver transplant recipients (mean age: 49.68±6.4 years; 44 men and six women). Delayed-onset chest infections that developed after the first month after transplant until the end of the first year were evaluated to determine their frequency, causative microorganisms, associated risk factors, and effect on mortality. Results Delayed-onset chest infections were detected in six patients (12%) and were complicated, with a 50% mortality rate. The causative organisms were carbapenemase-producing Enterobacteriaceae spp., multidrug-resistant Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus and Streptococcus pneumoniae. Only one case was diagnosed as pleural tuberculosis in the late period of 6–12 months post liver transplantation. The mortality rate was significantly higher in patients who developed chest infections than among those who developed graft- related complications (P=0.009). Persistent moderate-to-large post-transplant transudative pleural effusion and the use of tacrolimus were associated with increased frequency of post-transplant delayed-onset chest infections (P=0.029 and 0.021, respectively). Conclusion Despite the relatively low incidence of post-transplant delayed-onset pulmonary infections, they are a major cause of morbidity and mortality in liver transplant recipients. Tuberculosis should be considered as a cause of post-transplant delayed-onset chest infections. |
| first_indexed | 2024-12-20T14:46:42Z |
| format | Article |
| id | doaj.art-6eee66b6c76648ada7c8756378893321 |
| institution | Directory Open Access Journal |
| issn | 1687-8426 2314-8551 |
| language | English |
| last_indexed | 2024-12-20T14:46:42Z |
| publishDate | 2016-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Bronchology |
| spelling | doaj.art-6eee66b6c76648ada7c87563788933212022-12-21T19:37:06ZengSpringerOpenThe Egyptian Journal of Bronchology1687-84262314-85512016-06-0110214715410.4103/1687-8426.184362Delayed-onset chest infections in liver transplant recipients: a prospective studyMohammad Khairy El-Badrawy0Raed El-Metwaly Ali1Amr Mohamad Yassen2Mohammad Ahmad Abou Elela3Rehab Ahmad Elmorsey4Departments of Chest Medicine, Gastrointestinal Surgical Center, Faculty of Medicine, Mansoura UniversityDepartments of Chest Medicine, Gastrointestinal Surgical Center, Faculty of Medicine, Mansoura UniversityDepartments of Anesthesia and Intensive Care, Gastrointestinal Surgical Center, Faculty of Medicine, Mansoura UniversityDepartments of Medical Microbiology and Immunology, Gastrointestinal Surgical Center, Faculty of Medicine, Mansoura UniversityDepartments of Chest Medicine, Gastrointestinal Surgical Center, Faculty of Medicine, Mansoura UniversityAbstract Objectives Liver transplant recipients are liable to many infectious and noninfectious chest complications, especially post-transplant pneumonia, which is the major cause of morbidity and mortality. Many studies have evaluated post-liver-transplant early-onset pneumonia. The aim of this study was to evaluate delayed-onset chest infections following liver transplantation. Materials and methods This prospective study was carried out on 50 adult living donor liver transplant recipients (mean age: 49.68±6.4 years; 44 men and six women). Delayed-onset chest infections that developed after the first month after transplant until the end of the first year were evaluated to determine their frequency, causative microorganisms, associated risk factors, and effect on mortality. Results Delayed-onset chest infections were detected in six patients (12%) and were complicated, with a 50% mortality rate. The causative organisms were carbapenemase-producing Enterobacteriaceae spp., multidrug-resistant Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus and Streptococcus pneumoniae. Only one case was diagnosed as pleural tuberculosis in the late period of 6–12 months post liver transplantation. The mortality rate was significantly higher in patients who developed chest infections than among those who developed graft- related complications (P=0.009). Persistent moderate-to-large post-transplant transudative pleural effusion and the use of tacrolimus were associated with increased frequency of post-transplant delayed-onset chest infections (P=0.029 and 0.021, respectively). Conclusion Despite the relatively low incidence of post-transplant delayed-onset pulmonary infections, they are a major cause of morbidity and mortality in liver transplant recipients. Tuberculosis should be considered as a cause of post-transplant delayed-onset chest infections.http://link.springer.com/article/10.4103/1687-8426.184362chest infectionsdelayed onsetliver transplantation |
| spellingShingle | Mohammad Khairy El-Badrawy Raed El-Metwaly Ali Amr Mohamad Yassen Mohammad Ahmad Abou Elela Rehab Ahmad Elmorsey Delayed-onset chest infections in liver transplant recipients: a prospective study The Egyptian Journal of Bronchology chest infections delayed onset liver transplantation |
| title | Delayed-onset chest infections in liver transplant recipients: a prospective study |
| title_full | Delayed-onset chest infections in liver transplant recipients: a prospective study |
| title_fullStr | Delayed-onset chest infections in liver transplant recipients: a prospective study |
| title_full_unstemmed | Delayed-onset chest infections in liver transplant recipients: a prospective study |
| title_short | Delayed-onset chest infections in liver transplant recipients: a prospective study |
| title_sort | delayed onset chest infections in liver transplant recipients a prospective study |
| topic | chest infections delayed onset liver transplantation |
| url | http://link.springer.com/article/10.4103/1687-8426.184362 |
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