An efficient acetylation of dextran using in situ activated acetic anhydride with iodine
A facile, efficient, cost-effective and solvent-free acetylation method has been developed for the acetylation of dextran. Dextran acetates were successfully synthesized using different molar ratios of acetic anhydride in the presence of iodine as a catalyst without the use of any solvent. The react...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2010-02-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.shd.org.rs/JSCS/Vol75/No2/02_4392_3949.pdf |
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| author | MUHAMMAD A. HUSSAIN DURE SHAHWAR MUHAMMAD N. TAHIR MUHAMMAD SHER MUHAMMAD N. HASSAN ZAKIA AFZAL |
| author_facet | MUHAMMAD A. HUSSAIN DURE SHAHWAR MUHAMMAD N. TAHIR MUHAMMAD SHER MUHAMMAD N. HASSAN ZAKIA AFZAL |
| author_sort | MUHAMMAD A. HUSSAIN |
| collection | DOAJ |
| description | A facile, efficient, cost-effective and solvent-free acetylation method has been developed for the acetylation of dextran. Dextran acetates were successfully synthesized using different molar ratios of acetic anhydride in the presence of iodine as a catalyst without the use of any solvent. The reactions were realized at 50 °C for 3 h under stirring and nitrogen. This efficient method yielded highly pure and organosoluble dextran esters. The reaction appears highly effective for obtaining higher degrees of substitution (DS) with great efficiency. Under solvent-free conditions, dextran triacetates were efficiently synthesized. It was also observed that the molar ratio can easily control the DS of pendant groups onto the polymer backbone. Hence, a range of products with varying DS were successfully designed, purified and characterized. Covalent attachment of the pendant groups onto the polymer backbone was verified by spectroscopic techniques. Thermogravimetric analysis indicated that the obtained dextran esters were thermally as stable as dextran. The DS of the pendant groups onto the polymer backbone was calculated using standard acid base titration after saponification. Furthermore, all products were thoroughly characterized by thermal analysis (TG and DTG), and FTIR and 1H-NMR spectroscopic analysis. |
| first_indexed | 2024-04-14T04:35:01Z |
| format | Article |
| id | doaj.art-6eef1ba8fa0b443dbae5fd693ef49a7d |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-04-14T04:35:01Z |
| publishDate | 2010-02-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-6eef1ba8fa0b443dbae5fd693ef49a7d2022-12-22T02:11:55ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392010-02-01752165173An efficient acetylation of dextran using in situ activated acetic anhydride with iodineMUHAMMAD A. HUSSAINDURE SHAHWARMUHAMMAD N. TAHIRMUHAMMAD SHERMUHAMMAD N. HASSANZAKIA AFZALA facile, efficient, cost-effective and solvent-free acetylation method has been developed for the acetylation of dextran. Dextran acetates were successfully synthesized using different molar ratios of acetic anhydride in the presence of iodine as a catalyst without the use of any solvent. The reactions were realized at 50 °C for 3 h under stirring and nitrogen. This efficient method yielded highly pure and organosoluble dextran esters. The reaction appears highly effective for obtaining higher degrees of substitution (DS) with great efficiency. Under solvent-free conditions, dextran triacetates were efficiently synthesized. It was also observed that the molar ratio can easily control the DS of pendant groups onto the polymer backbone. Hence, a range of products with varying DS were successfully designed, purified and characterized. Covalent attachment of the pendant groups onto the polymer backbone was verified by spectroscopic techniques. Thermogravimetric analysis indicated that the obtained dextran esters were thermally as stable as dextran. The DS of the pendant groups onto the polymer backbone was calculated using standard acid base titration after saponification. Furthermore, all products were thoroughly characterized by thermal analysis (TG and DTG), and FTIR and 1H-NMR spectroscopic analysis.http://www.shd.org.rs/JSCS/Vol75/No2/02_4392_3949.pdfacetic anhydrideacetylationdextraniodinepolysaccharide |
| spellingShingle | MUHAMMAD A. HUSSAIN DURE SHAHWAR MUHAMMAD N. TAHIR MUHAMMAD SHER MUHAMMAD N. HASSAN ZAKIA AFZAL An efficient acetylation of dextran using in situ activated acetic anhydride with iodine Journal of the Serbian Chemical Society acetic anhydride acetylation dextran iodine polysaccharide |
| title | An efficient acetylation of dextran using in situ activated acetic anhydride with iodine |
| title_full | An efficient acetylation of dextran using in situ activated acetic anhydride with iodine |
| title_fullStr | An efficient acetylation of dextran using in situ activated acetic anhydride with iodine |
| title_full_unstemmed | An efficient acetylation of dextran using in situ activated acetic anhydride with iodine |
| title_short | An efficient acetylation of dextran using in situ activated acetic anhydride with iodine |
| title_sort | efficient acetylation of dextran using in situ activated acetic anhydride with iodine |
| topic | acetic anhydride acetylation dextran iodine polysaccharide |
| url | http://www.shd.org.rs/JSCS/Vol75/No2/02_4392_3949.pdf |
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