Selection signature analysis reveals <i>RDH5</i> performed key function in vision during sheep domestication process
<p>As one of the most successful domesticated animals in the Neolithic age, sheep gradually migrated all over the world with human activities. During the domestication process, remarkable changes have taken place in morphology, physiology, and behavior, resulting in different breeds with diffe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Copernicus Publications
2023-02-01
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| Series: | Archives Animal Breeding |
| Online Access: | https://aab.copernicus.org/articles/66/81/2023/aab-66-81-2023.pdf |
| _version_ | 1797895978650435584 |
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| author | R. Hu R. Hu X. Jiang X. Jiang H. Yang G. Liu G. Liu |
| author_facet | R. Hu R. Hu X. Jiang X. Jiang H. Yang G. Liu G. Liu |
| author_sort | R. Hu |
| collection | DOAJ |
| description | <p>As one of the most successful domesticated animals in the Neolithic age,
sheep gradually migrated all over the world with human activities. During the
domestication process, remarkable changes have taken place in morphology,
physiology, and behavior, resulting in different breeds with different
characters via artificial and natural selection. However, the genetic
background responsible for these phenotypic variations remains largely
unclear. Here, we used whole genome resequencing technology to compare and
analyze the genome differences between Asiatic mouflon wild sheep (<i>Ovis orientalis</i>) and Hu
sheep (<i>Ovis aries</i>). A total of 755 genes were positively selected in the process of
domestication and selection, and the genes related to sensory perception had
directional evolution in the autosomal region, such as <i>OPRL1, LEF1, TAS1R3, ATF6, VSX2, MYO1A, RDH5</i>, and some novel
genes. A missense mutation of c.T722C/p.M241T in exon 4 of <i>RDH5</i> existing in sheep
were found, and the <i>T</i> allele was completely fixed in Hu sheep. In addition, the
mutation with the <i>C</i> allele reduced the retinol dehydrogenase activity encoding
by <i>RDH5</i>, which can impair retinoic acid metabolism and further influenced the visual
cycle. Overall, our results showed significant enrichment for positively
selected genes involved in sensory perception development during sheep
domestication; <i>RDH5</i> and its variants may be related to the retinal degeneration
in sheep. We infer that the wild sheep ancestors with weaker visual sensitivity
were weeded out by humans, and the mutation was selective, swept by the dual
pressures of natural and artificial selection.</p> |
| first_indexed | 2024-04-10T07:34:19Z |
| format | Article |
| id | doaj.art-6ef109186478438e841e4aa596dedbad |
| institution | Directory Open Access Journal |
| issn | 0003-9438 2363-9822 |
| language | English |
| last_indexed | 2024-04-10T07:34:19Z |
| publishDate | 2023-02-01 |
| publisher | Copernicus Publications |
| record_format | Article |
| series | Archives Animal Breeding |
| spelling | doaj.art-6ef109186478438e841e4aa596dedbad2023-02-23T13:00:11ZengCopernicus PublicationsArchives Animal Breeding0003-94382363-98222023-02-0166819110.5194/aab-66-81-2023Selection signature analysis reveals <i>RDH5</i> performed key function in vision during sheep domestication processR. Hu0R. Hu1X. Jiang2X. Jiang3H. Yang4G. Liu5G. Liu6Laboratory of Small Ruminant Genetics, Breeding and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR ChinaKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, Wuhan 430070, PR ChinaLaboratory of Small Ruminant Genetics, Breeding and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR ChinaKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, Wuhan 430070, PR ChinaInstitute of Animal Husbandry, Xinjiang Academy of Animal Sciences, Urumqi 830000, PR ChinaLaboratory of Small Ruminant Genetics, Breeding and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR ChinaKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, Wuhan 430070, PR China<p>As one of the most successful domesticated animals in the Neolithic age, sheep gradually migrated all over the world with human activities. During the domestication process, remarkable changes have taken place in morphology, physiology, and behavior, resulting in different breeds with different characters via artificial and natural selection. However, the genetic background responsible for these phenotypic variations remains largely unclear. Here, we used whole genome resequencing technology to compare and analyze the genome differences between Asiatic mouflon wild sheep (<i>Ovis orientalis</i>) and Hu sheep (<i>Ovis aries</i>). A total of 755 genes were positively selected in the process of domestication and selection, and the genes related to sensory perception had directional evolution in the autosomal region, such as <i>OPRL1, LEF1, TAS1R3, ATF6, VSX2, MYO1A, RDH5</i>, and some novel genes. A missense mutation of c.T722C/p.M241T in exon 4 of <i>RDH5</i> existing in sheep were found, and the <i>T</i> allele was completely fixed in Hu sheep. In addition, the mutation with the <i>C</i> allele reduced the retinol dehydrogenase activity encoding by <i>RDH5</i>, which can impair retinoic acid metabolism and further influenced the visual cycle. Overall, our results showed significant enrichment for positively selected genes involved in sensory perception development during sheep domestication; <i>RDH5</i> and its variants may be related to the retinal degeneration in sheep. We infer that the wild sheep ancestors with weaker visual sensitivity were weeded out by humans, and the mutation was selective, swept by the dual pressures of natural and artificial selection.</p>https://aab.copernicus.org/articles/66/81/2023/aab-66-81-2023.pdf |
| spellingShingle | R. Hu R. Hu X. Jiang X. Jiang H. Yang G. Liu G. Liu Selection signature analysis reveals <i>RDH5</i> performed key function in vision during sheep domestication process Archives Animal Breeding |
| title | Selection signature analysis reveals <i>RDH5</i> performed key function in vision during sheep domestication process |
| title_full | Selection signature analysis reveals <i>RDH5</i> performed key function in vision during sheep domestication process |
| title_fullStr | Selection signature analysis reveals <i>RDH5</i> performed key function in vision during sheep domestication process |
| title_full_unstemmed | Selection signature analysis reveals <i>RDH5</i> performed key function in vision during sheep domestication process |
| title_short | Selection signature analysis reveals <i>RDH5</i> performed key function in vision during sheep domestication process |
| title_sort | selection signature analysis reveals i rdh5 i performed key function in vision during sheep domestication process |
| url | https://aab.copernicus.org/articles/66/81/2023/aab-66-81-2023.pdf |
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