Domains in Action: Understanding Ddi1’s Diverse Functions in the Ubiquitin-Proteasome System

Domains in Action: Understanding Ddi1’s Diverse Functions in the Ubiquitin-Proteasome System

The ubiquitin-proteasome system (UPS) is a pivotal cellular mechanism responsible for the selective degradation of proteins, playing an essential role in proteostasis, protein quality control, and regulating various cellular processes, with ubiquitin marking proteins for degradation through a comple...

Full description

Bibliographic Details
Main Authors:	Artur Fabijan, Bartosz Polis, Agnieszka Zawadzka-Fabijan, Izabela Korabiewska, Krzysztof Zakrzewski, Emilia Nowosławska, Michał Chojnacki
Format:	Article
Language:	English
Published:	MDPI AG 2024-04-01
Series:	International Journal of Molecular Sciences
Subjects:	ubiquitin (Ub) DNA-damage inducible protein 1 (Ddi1) ubiquitin-proteasome system (UPS) ubiquitin-like domain (UBL) ubiquitin associated domain (UBA) retroviral-like protease domain (RVP)
Online Access:	https://www.mdpi.com/1422-0067/25/7/4080

Similar Items

Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration
by: Salinee Jantrapirom, et al.
Published: (2019-04-01)

Editorial: Structure, Function, and Evolution of E3 Ligases and Targets
by: Derek J. Gingerich, et al.
Published: (2021-10-01)

Early recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2
by: Ibtisam Ibtisam, et al.
Published: (2024-04-01)

Ubiquitin Engineering for Interrogating the Ubiquitin–Proteasome System and Novel Therapeutic Strategies
by: Jason Q. Tang, et al.
Published: (2023-08-01)

Genome-wide analysis of genes encoding core components of the ubiquitin system in soybean (Glycine max) reveals a potential role for ubiquitination in host immunity against soybean cyst nematode
by: Chunyu Zhang, et al.
Published: (2018-07-01)

Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling
by: Anmol Sharma, et al.
Published: (2021-11-01)

Ubiquitin and Ubiquitin-Like Proteins and Domains in Ribosome Production and Function: Chance or Necessity?
by: Sara Martín-Villanueva, et al.
Published: (2021-04-01)

Editorial: Reviews in ubiquitin signaling: 2022
by: Adam J. Fletcher, et al.
Published: (2023-08-01)

Kinetic Constraints in the Specific Interaction between Phosphorylated Ubiquitin and Proteasomal Shuttle Factors
by: Ling-Yun Qin, et al.
Published: (2021-07-01)

Ubiquitination in the ERAD Process
by: Anna Lopata, et al.
Published: (2020-07-01)

Role of Ubiquitin-Proteasome in Spermatogenesis Process
by: Erfaneh Shaygannia, et al.
Published: (2014-08-01)

Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival
by: Gabriela Vargas, et al.
Published: (2022-03-01)

Interplay between the Ubiquitin Proteasome System and Ubiquitin-Mediated Autophagy in Plants
by: Tong Su, et al.
Published: (2020-10-01)

Targeted Regulation of Nuclear Lamins by Ubiquitin and Ubiquitin-Like Modifiers
by: Michael Blank
Published: (2020-05-01)

Ubiquitin fragments: their known biological activities and putative roles
by: Pasikowski Paweł, et al.
Published: (2010-05-01)

From the Evasion of Degradation to Ubiquitin-Dependent Protein Stabilization
by: Yamen Abu Ahmad, et al.
Published: (2021-09-01)

Functional role of WW domain‐containing proteins in tumor biology and diseases: Insight into the role in ubiquitin‐proteasome system
by: Shenq‐Shyang Huang, et al.
Published: (2020-04-01)

The ubiquitin-proteasome system in glioma cell cycle control
by: Vlachostergios Panagiotis J, et al.
Published: (2012-07-01)

Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system
by: Piotr Bragoszewski, et al.
Published: (2017-01-01)

Ubiquitin and Ubiquitin-like Proteins in Cancer, Neurodegenerative Disorders, and Heart Diseases
by: Jin-Taek Hwang, et al.
Published: (2022-05-01)

The Ubiquitin Conjugating Enzyme: An Important Ubiquitin Transfer Platform in Ubiquitin-Proteasome System
by: Weigang Liu, et al.
Published: (2020-04-01)

Mechanisms That Activate 26S Proteasomes and Enhance Protein Degradation
by: Alfred L. Goldberg, et al.
Published: (2021-05-01)

A New Potential Therapeutic Target for Cancer in Ubiquitin-Like Proteins—UBL3
by: Hengsen Zhang, et al.
Published: (2023-01-01)

Local ubiquitin-proteasome-mediated proteolysis and long-term synaptic plasticity
by: Ashok eHegde, et al.
Published: (2014-12-01)

Targeting the Ubiquitin-Proteasome System for Cancer Therapeutics by Small-Molecule Inhibitors
by: Gabriel LaPlante, et al.
Published: (2021-06-01)

Involvement in Fertilization and Expression of Gamete Ubiquitin-Activating Enzymes UBA1 and UBA6 in the Ascidian <i>Halocynthia roretzi</i>
by: Hitoshi Sawada, et al.
Published: (2023-06-01)

Viral Takeover of the Host Ubiquitin System
by: Jean K Gustin, et al.
Published: (2011-07-01)

A cryptic K48 ubiquitin chain binding site on UCH37 is required for its role in proteasomal degradation
by: Jiale Du, et al.
Published: (2022-04-01)

Assembly and disassembly of branched ubiquitin chains
by: Justin B. Gregor, et al.
Published: (2023-06-01)

Control of DNA Replication Initiation by Ubiquitin
by: Esperanza Hernández-Carralero, et al.
Published: (2018-09-01)

The 26S Proteasome Switches between ATP-Dependent and -Independent Mechanisms in Response to Substrate Ubiquitination
by: Abramo J. Manfredonia, et al.
Published: (2022-05-01)

Mechanisms Regulating the UPS-ALS Crosstalk: The Role of Proteaphagy
by: Grégoire Quinet, et al.
Published: (2020-05-01)

Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis
by: Ishita Gupta, et al.
Published: (2018-02-01)

The Roles of Ubiquitin-Binding Protein Shuttles in the Degradative Fate of Ubiquitinated Proteins in the Ubiquitin-Proteasome System and Autophagy
by: Katarzyna Zientara-Rytter, et al.
Published: (2019-01-01)

Emerging Roles of Non-proteolytic Ubiquitination in Tumorigenesis
by: Xiu Yin, et al.
Published: (2022-07-01)

The roles of protein ubiquitination in tumorigenesis and targeted drug discovery in lung cancer
by: Zhen Ye, et al.
Published: (2023-09-01)

The Ubiquitin Proteasome System and Nutrient Stress Response
by: Erin Mackinnon, et al.
Published: (2022-05-01)

A heterozygous p.S143P mutation in LMNA associates with proteasome dysfunction and enhanced autophagy-mediated degradation of mutant lamins A and C
by: Gun West, et al.
Published: (2022-08-01)

Proteins Directly Interacting with Mammalian 20S Proteasomal Subunits and Ubiquitin-Independent Proteasomal Degradation
by: Raúl Sánchez-Lanzas, et al.
Published: (2014-12-01)

Emergence of Members of TRAF and DUB of Ubiquitin Proteasome System in the Regulation of Hypertrophic Cardiomyopathy
by: Ishita Gupta, et al.
Published: (2018-08-01)