In vivo anti-diabetic effect of aqueous and methanolic macerated extracts of Atractylis gummifera
The anti-diabetic effect of Atractylis gummifera (plant used in traditional Moroccan medicine) has been evaluated in type 2 diabetic mice model. The mice were divided into five groups: Normal control, diabetic control, diabetic treated with aqueous macerate (500 mg/kg), diabetic treated with methano...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2019-04-01
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| Series: | Bangladesh Journal of Pharmacology |
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| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/38870 |
| _version_ | 1831518967676534784 |
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| author | Khadija Bouabid Fatima Lamchouri Hamid Toufik Mohamed Boulfia Souad Senhaji My El Abbes Faouzi |
| author_facet | Khadija Bouabid Fatima Lamchouri Hamid Toufik Mohamed Boulfia Souad Senhaji My El Abbes Faouzi |
| author_sort | Khadija Bouabid |
| collection | DOAJ |
| description | The anti-diabetic effect of Atractylis gummifera (plant used in traditional Moroccan medicine) has been evaluated in type 2 diabetic mice model. The mice were divided into five groups: Normal control, diabetic control, diabetic treated with aqueous macerate (500 mg/kg), diabetic treated with methanol macerate (500 mg/kg) and diabetic treated with metformin (300 mg/kg). The treatment of the mice was performed by daily gastric gavage for 5 weeks. The monitoring of the mice was carried out weekly by fasting glucose and measurement of biochemical parameters at the end of treatment. The aqueous macerate of A. gummifera was most effective that reduced the fasting blood glucose with 62.7%. In addition, this extract restored the biochemical parameters of diabetic mice to normal. |
| first_indexed | 2024-12-13T17:05:33Z |
| format | Article |
| id | doaj.art-6ef48b088b8f450087902107c658b2fd |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-13T17:05:33Z |
| publishDate | 2019-04-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-6ef48b088b8f450087902107c658b2fd2022-12-21T23:37:42ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882019-04-0114210.3329/bjp.v14i2.38870In vivo anti-diabetic effect of aqueous and methanolic macerated extracts of Atractylis gummiferaKhadija Bouabid0Fatima Lamchouri1Hamid Toufik2Mohamed Boulfia3Souad Senhaji4My El Abbes Faouzi5Laboratory of Materials, Natural Substances, Environment and Modeling, Polydisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University of Fez B. P., 1223 Taza-Gare, TazaLaboratory of Materials, Natural Substances, Environment and Modeling (LMSNEM), Polydisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University of Fez Morocco.Laboratory of Materials, Natural Substances, Environment and Modeling, Polydisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University of Fez B. P., 1223 Taza-Gare, TazaLaboratory of Materials, Natural Substances, Environment and Modeling, Polydisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University of Fez B. P., 1223 Taza-Gare, TazaLaboratory of Materials, Natural Substances, Environment and Modeling, Polydisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University of Fez B. P., 1223 Taza-Gare, TazaLaboratory of Pharmacology and Toxicology, Pharmacokinetics Research Team, Faculty of Medicine and Pharmacy, Mohammed V University, BP 6203, Rabat-Institutes, RabatThe anti-diabetic effect of Atractylis gummifera (plant used in traditional Moroccan medicine) has been evaluated in type 2 diabetic mice model. The mice were divided into five groups: Normal control, diabetic control, diabetic treated with aqueous macerate (500 mg/kg), diabetic treated with methanol macerate (500 mg/kg) and diabetic treated with metformin (300 mg/kg). The treatment of the mice was performed by daily gastric gavage for 5 weeks. The monitoring of the mice was carried out weekly by fasting glucose and measurement of biochemical parameters at the end of treatment. The aqueous macerate of A. gummifera was most effective that reduced the fasting blood glucose with 62.7%. In addition, this extract restored the biochemical parameters of diabetic mice to normal.https://www.banglajol.info/index.php/BJP/article/view/38870Atractylis gummifera L.Aqueous macerateDiabetes mellitus |
| spellingShingle | Khadija Bouabid Fatima Lamchouri Hamid Toufik Mohamed Boulfia Souad Senhaji My El Abbes Faouzi In vivo anti-diabetic effect of aqueous and methanolic macerated extracts of Atractylis gummifera Bangladesh Journal of Pharmacology Atractylis gummifera L. Aqueous macerate Diabetes mellitus |
| title | In vivo anti-diabetic effect of aqueous and methanolic macerated extracts of Atractylis gummifera |
| title_full | In vivo anti-diabetic effect of aqueous and methanolic macerated extracts of Atractylis gummifera |
| title_fullStr | In vivo anti-diabetic effect of aqueous and methanolic macerated extracts of Atractylis gummifera |
| title_full_unstemmed | In vivo anti-diabetic effect of aqueous and methanolic macerated extracts of Atractylis gummifera |
| title_short | In vivo anti-diabetic effect of aqueous and methanolic macerated extracts of Atractylis gummifera |
| title_sort | in vivo anti diabetic effect of aqueous and methanolic macerated extracts of atractylis gummifera |
| topic | Atractylis gummifera L. Aqueous macerate Diabetes mellitus |
| url | https://www.banglajol.info/index.php/BJP/article/view/38870 |
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