The Roles of 2-Hydroxyglutarate
2-Hydroxyglutarate (2-HG) is structurally similar to α-ketoglutarate (α-KG), which is an intermediate product of the tricarboxylic acid (TCA) cycle; it can be generated by reducing the ketone group of α-KG to a hydroxyl group. The significant role that 2-HG plays has been certified in the pathophysi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.651317/full |
| _version_ | 1828911267491872768 |
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| author | Xin Du Xin Du Hai Hu Hai Hu |
| author_facet | Xin Du Xin Du Hai Hu Hai Hu |
| author_sort | Xin Du |
| collection | DOAJ |
| description | 2-Hydroxyglutarate (2-HG) is structurally similar to α-ketoglutarate (α-KG), which is an intermediate product of the tricarboxylic acid (TCA) cycle; it can be generated by reducing the ketone group of α-KG to a hydroxyl group. The significant role that 2-HG plays has been certified in the pathophysiology of 2-hydroxyglutaric aciduria (2HGA), tumors harboring mutant isocitrate dehydrogenase 1/2 (IDH1/2mt), and in clear cell renal cell carcinoma (ccRCC). It is taken as an oncometabolite, raising much attention on its oncogenic mechanism. In recent years, 2-HG has been verified to accumulate in the context of hypoxia or acidic pH, and there are also researches confirming the vital role that 2-HG plays in the fate decision of immune cells. Therefore, 2-HG not only participates in tumorigenesis. This text will also summarize 2-HG’s identities besides being an oncometabolite and will discuss their enlightenment for future research and clinical treatment. |
| first_indexed | 2024-12-13T18:59:48Z |
| format | Article |
| id | doaj.art-6ef4a89115b547cbb5908ca89639b053 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-13T18:59:48Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-6ef4a89115b547cbb5908ca89639b0532022-12-21T23:34:43ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-03-01910.3389/fcell.2021.651317651317The Roles of 2-HydroxyglutarateXin Du0Xin Du1Hai Hu2Hai Hu3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China2-Hydroxyglutarate (2-HG) is structurally similar to α-ketoglutarate (α-KG), which is an intermediate product of the tricarboxylic acid (TCA) cycle; it can be generated by reducing the ketone group of α-KG to a hydroxyl group. The significant role that 2-HG plays has been certified in the pathophysiology of 2-hydroxyglutaric aciduria (2HGA), tumors harboring mutant isocitrate dehydrogenase 1/2 (IDH1/2mt), and in clear cell renal cell carcinoma (ccRCC). It is taken as an oncometabolite, raising much attention on its oncogenic mechanism. In recent years, 2-HG has been verified to accumulate in the context of hypoxia or acidic pH, and there are also researches confirming the vital role that 2-HG plays in the fate decision of immune cells. Therefore, 2-HG not only participates in tumorigenesis. This text will also summarize 2-HG’s identities besides being an oncometabolite and will discuss their enlightenment for future research and clinical treatment.https://www.frontiersin.org/articles/10.3389/fcell.2021.651317/full2-Hydroxyglutarateepigeneticsmetabolismimmunologyisocitrate dehydrogenase |
| spellingShingle | Xin Du Xin Du Hai Hu Hai Hu The Roles of 2-Hydroxyglutarate Frontiers in Cell and Developmental Biology 2-Hydroxyglutarate epigenetics metabolism immunology isocitrate dehydrogenase |
| title | The Roles of 2-Hydroxyglutarate |
| title_full | The Roles of 2-Hydroxyglutarate |
| title_fullStr | The Roles of 2-Hydroxyglutarate |
| title_full_unstemmed | The Roles of 2-Hydroxyglutarate |
| title_short | The Roles of 2-Hydroxyglutarate |
| title_sort | roles of 2 hydroxyglutarate |
| topic | 2-Hydroxyglutarate epigenetics metabolism immunology isocitrate dehydrogenase |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.651317/full |
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