Prolonged post-ablation fever may predict one-year tumor recurrence in hepatocellular carcinoma after radiofrequency ablation
Background The impact of prolonged post-ablation fever (PAF) defined as persistent fever > 24 h after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) had not been described before. This study aims to investigate the impact of prolonged PAF on early tumor recurrence in HCC patient...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | http://dx.doi.org/10.1080/02656736.2020.1806363 |
| _version_ | 1828913948120842240 |
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| author | Ping-Hung Ho Wei Teng Chen-Chun Lin Wen-Juei Jeng Wei-Ting Chen Chun-Yen Lin Shi-Ming Lin I-Shyan Sheen |
| author_facet | Ping-Hung Ho Wei Teng Chen-Chun Lin Wen-Juei Jeng Wei-Ting Chen Chun-Yen Lin Shi-Ming Lin I-Shyan Sheen |
| author_sort | Ping-Hung Ho |
| collection | DOAJ |
| description | Background The impact of prolonged post-ablation fever (PAF) defined as persistent fever > 24 h after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) had not been described before. This study aims to investigate the impact of prolonged PAF on early tumor recurrence in HCC patients after RFA. Methods From 2013 to 2015, a total of 135 patients with HCC meeting Milan criteria and all the tumors having confirmed complete ablation after RFA were enrolled. Study endpoint was any HCC recurrence within 1 year after ablation. Cox regression analysis was applied for multivariate analysis to determine the independent predictors of 1-year tumor recurrence. Results Post-ablation fever occurred in 42 (31.1%) patients after RFA, while prolonged PAF was found in 22 (16.3%) patients. Fifty-eight (42.8%) patients occurred any tumor recurrence within 1 year after complete ablation. Patients with prolonged PAF had a significantly higher rate of HCC recurrence within 1 year (72.7% vs. 37.1%, p = 0.002) and had a significantly shorter time-to-recurrence interval (19.6 vs. 40.5 months, Log rank test, p = 0.002) than those who had no prolonged PAF. Multivariate analysis by Cox regression showed the previous HCC recurrence history (aHR: 1.792, p = 0.0284), baseline AFP > 20 ng/ml (aHR: 1.868, p = 0.0211) and prolonged PAF (aHR: 2.092, p = 0.0138) were associated with early recurrence. Conclusions Prolonged PAF may associate with early HCC recurrence after complete ablation by RFA. Patients with prolonged PAF need to be more clinical attentions. |
| first_indexed | 2024-12-13T19:47:23Z |
| format | Article |
| id | doaj.art-6ef65b7382f741f3a79b07cde2dc23d1 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-12-13T19:47:23Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-6ef65b7382f741f3a79b07cde2dc23d12022-12-21T23:33:32ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572020-01-013711008101510.1080/02656736.2020.18063631806363Prolonged post-ablation fever may predict one-year tumor recurrence in hepatocellular carcinoma after radiofrequency ablationPing-Hung Ho0Wei Teng1Chen-Chun Lin2Wen-Juei Jeng3Wei-Ting Chen4Chun-Yen Lin5Shi-Ming Lin6I-Shyan Sheen7Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical CenterDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical CenterDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical CenterDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical CenterDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical CenterDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical CenterDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical CenterDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical CenterBackground The impact of prolonged post-ablation fever (PAF) defined as persistent fever > 24 h after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) had not been described before. This study aims to investigate the impact of prolonged PAF on early tumor recurrence in HCC patients after RFA. Methods From 2013 to 2015, a total of 135 patients with HCC meeting Milan criteria and all the tumors having confirmed complete ablation after RFA were enrolled. Study endpoint was any HCC recurrence within 1 year after ablation. Cox regression analysis was applied for multivariate analysis to determine the independent predictors of 1-year tumor recurrence. Results Post-ablation fever occurred in 42 (31.1%) patients after RFA, while prolonged PAF was found in 22 (16.3%) patients. Fifty-eight (42.8%) patients occurred any tumor recurrence within 1 year after complete ablation. Patients with prolonged PAF had a significantly higher rate of HCC recurrence within 1 year (72.7% vs. 37.1%, p = 0.002) and had a significantly shorter time-to-recurrence interval (19.6 vs. 40.5 months, Log rank test, p = 0.002) than those who had no prolonged PAF. Multivariate analysis by Cox regression showed the previous HCC recurrence history (aHR: 1.792, p = 0.0284), baseline AFP > 20 ng/ml (aHR: 1.868, p = 0.0211) and prolonged PAF (aHR: 2.092, p = 0.0138) were associated with early recurrence. Conclusions Prolonged PAF may associate with early HCC recurrence after complete ablation by RFA. Patients with prolonged PAF need to be more clinical attentions.http://dx.doi.org/10.1080/02656736.2020.1806363hccrfaearly recurrencenlrfever |
| spellingShingle | Ping-Hung Ho Wei Teng Chen-Chun Lin Wen-Juei Jeng Wei-Ting Chen Chun-Yen Lin Shi-Ming Lin I-Shyan Sheen Prolonged post-ablation fever may predict one-year tumor recurrence in hepatocellular carcinoma after radiofrequency ablation International Journal of Hyperthermia hcc rfa early recurrence nlr fever |
| title | Prolonged post-ablation fever may predict one-year tumor recurrence in hepatocellular carcinoma after radiofrequency ablation |
| title_full | Prolonged post-ablation fever may predict one-year tumor recurrence in hepatocellular carcinoma after radiofrequency ablation |
| title_fullStr | Prolonged post-ablation fever may predict one-year tumor recurrence in hepatocellular carcinoma after radiofrequency ablation |
| title_full_unstemmed | Prolonged post-ablation fever may predict one-year tumor recurrence in hepatocellular carcinoma after radiofrequency ablation |
| title_short | Prolonged post-ablation fever may predict one-year tumor recurrence in hepatocellular carcinoma after radiofrequency ablation |
| title_sort | prolonged post ablation fever may predict one year tumor recurrence in hepatocellular carcinoma after radiofrequency ablation |
| topic | hcc rfa early recurrence nlr fever |
| url | http://dx.doi.org/10.1080/02656736.2020.1806363 |
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