Targeting autophagy to counteract neuroinflammation: A novel antidepressant strategy
Depression is a common disease that affects physical and mental health and imposes a considerable burden on afflicted individuals and their families worldwide. Depression is associated with a high rate of disability and suicide. It causes a severe decline in productivity and quality of life. Unfortu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661824000562 |
| _version_ | 1797246797727399936 |
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| author | Hua Gan Qingyu Ma Wenzhi Hao Nating Yang Zhe-Sheng Chen Lijuan Deng Jiaxu Chen |
| author_facet | Hua Gan Qingyu Ma Wenzhi Hao Nating Yang Zhe-Sheng Chen Lijuan Deng Jiaxu Chen |
| author_sort | Hua Gan |
| collection | DOAJ |
| description | Depression is a common disease that affects physical and mental health and imposes a considerable burden on afflicted individuals and their families worldwide. Depression is associated with a high rate of disability and suicide. It causes a severe decline in productivity and quality of life. Unfortunately, the pathophysiological mechanisms underlying depression have not been fully elucidated, and the risk of its treatment is still presented. Studies have shown that the expression of autophagic markers in the brain and peripheral inflammatory mediators are dysregulated in depression. Autophagy-related genes regulate the level of autophagy and change the inflammatory response in depression. Depression is related to several aspects of immunity. The regulation of the immune system and inflammation by autophagy may lead to the development or deterioration of mental disorders. This review highlights the role of autophagy and neuroinflammation in the pathophysiology of depression, sumaries the autophagy-targeting small moleculars, and discusses a novel therapeutic strategy based on anti-inflammatory mechanisms that target autophagy to treat the disease. |
| first_indexed | 2024-03-07T21:54:18Z |
| format | Article |
| id | doaj.art-6ef6d638917646e3878bc45715af0354 |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-04-24T19:48:31Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-6ef6d638917646e3878bc45715af03542024-03-25T04:17:10ZengElsevierPharmacological Research1096-11862024-04-01202107112Targeting autophagy to counteract neuroinflammation: A novel antidepressant strategyHua Gan0Qingyu Ma1Wenzhi Hao2Nating Yang3Zhe-Sheng Chen4Lijuan Deng5Jiaxu Chen6Guangzhou Key Laboratory of Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, ChinaGuangzhou Key Laboratory of Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, ChinaGuangzhou Key Laboratory of Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, ChinaGuangzhou Key Laboratory of Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, ChinaDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA; Corresponding authors.Guangzhou Key Laboratory of Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China; Corresponding authors.Guangzhou Key Laboratory of Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; Corresponding author at: Guangzhou Key Laboratory of Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.Depression is a common disease that affects physical and mental health and imposes a considerable burden on afflicted individuals and their families worldwide. Depression is associated with a high rate of disability and suicide. It causes a severe decline in productivity and quality of life. Unfortunately, the pathophysiological mechanisms underlying depression have not been fully elucidated, and the risk of its treatment is still presented. Studies have shown that the expression of autophagic markers in the brain and peripheral inflammatory mediators are dysregulated in depression. Autophagy-related genes regulate the level of autophagy and change the inflammatory response in depression. Depression is related to several aspects of immunity. The regulation of the immune system and inflammation by autophagy may lead to the development or deterioration of mental disorders. This review highlights the role of autophagy and neuroinflammation in the pathophysiology of depression, sumaries the autophagy-targeting small moleculars, and discusses a novel therapeutic strategy based on anti-inflammatory mechanisms that target autophagy to treat the disease.http://www.sciencedirect.com/science/article/pii/S1043661824000562DepressionNeuroinflammationAutophagyPathophysiologySmall molecular |
| spellingShingle | Hua Gan Qingyu Ma Wenzhi Hao Nating Yang Zhe-Sheng Chen Lijuan Deng Jiaxu Chen Targeting autophagy to counteract neuroinflammation: A novel antidepressant strategy Pharmacological Research Depression Neuroinflammation Autophagy Pathophysiology Small molecular |
| title | Targeting autophagy to counteract neuroinflammation: A novel antidepressant strategy |
| title_full | Targeting autophagy to counteract neuroinflammation: A novel antidepressant strategy |
| title_fullStr | Targeting autophagy to counteract neuroinflammation: A novel antidepressant strategy |
| title_full_unstemmed | Targeting autophagy to counteract neuroinflammation: A novel antidepressant strategy |
| title_short | Targeting autophagy to counteract neuroinflammation: A novel antidepressant strategy |
| title_sort | targeting autophagy to counteract neuroinflammation a novel antidepressant strategy |
| topic | Depression Neuroinflammation Autophagy Pathophysiology Small molecular |
| url | http://www.sciencedirect.com/science/article/pii/S1043661824000562 |
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