Topical phage therapy in a mouse model of Cutibacterium acnes-induced acne-like lesions

Bacteriophage therapy is evolving as a promising approach to tackling bacterial infection, even in the case of emerging antibiotic resistance. In this work, authors present the topical application of numerous Cutibacterium acnes phage in an in vivo mouse model of acne vulgaris.

Bibliographic Details
Main Authors: Amit Rimon, Chani Rakov, Vanda Lerer, Sivan Sheffer-Levi, Sivan Alkalay Oren, Tehila Shlomov, Lihi Shasha, Ruth Lubin, Khaled Zubeidat, Nora Jaber, Musa Mujahed, Asaf Wilensky, Shunit Coppenhagen-Glazer, Vered Molho-Pessach, Ronen Hazan
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36694-8
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author Amit Rimon
Chani Rakov
Vanda Lerer
Sivan Sheffer-Levi
Sivan Alkalay Oren
Tehila Shlomov
Lihi Shasha
Ruth Lubin
Khaled Zubeidat
Nora Jaber
Musa Mujahed
Asaf Wilensky
Shunit Coppenhagen-Glazer
Vered Molho-Pessach
Ronen Hazan
author_facet Amit Rimon
Chani Rakov
Vanda Lerer
Sivan Sheffer-Levi
Sivan Alkalay Oren
Tehila Shlomov
Lihi Shasha
Ruth Lubin
Khaled Zubeidat
Nora Jaber
Musa Mujahed
Asaf Wilensky
Shunit Coppenhagen-Glazer
Vered Molho-Pessach
Ronen Hazan
author_sort Amit Rimon
collection DOAJ
description Bacteriophage therapy is evolving as a promising approach to tackling bacterial infection, even in the case of emerging antibiotic resistance. In this work, authors present the topical application of numerous Cutibacterium acnes phage in an in vivo mouse model of acne vulgaris.
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spelling doaj.art-6ef7adf4c33447258b06814edc850e952023-03-22T11:42:37ZengNature PortfolioNature Communications2041-17232023-02-0114111810.1038/s41467-023-36694-8Topical phage therapy in a mouse model of Cutibacterium acnes-induced acne-like lesionsAmit Rimon0Chani Rakov1Vanda Lerer2Sivan Sheffer-Levi3Sivan Alkalay Oren4Tehila Shlomov5Lihi Shasha6Ruth Lubin7Khaled Zubeidat8Nora Jaber9Musa Mujahed10Asaf Wilensky11Shunit Coppenhagen-Glazer12Vered Molho-Pessach13Ronen Hazan14Institute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, The Hebrew University of JerusalemInstitute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, The Hebrew University of JerusalemInstitute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, The Hebrew University of JerusalemDepartment of Dermatology, Hadassah Medical Center, The Faculty of Medicine, The Hebrew University of JerusalemInstitute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, The Hebrew University of JerusalemDepartment of Ophthalmology, Hadassah Medical Center, The Faculty of Medicine, The Hebrew University of JerusalemInstitute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, The Hebrew University of JerusalemInstitute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, The Hebrew University of JerusalemInstitute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, The Hebrew University of JerusalemInstitute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, The Hebrew University of JerusalemInstitute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, The Hebrew University of JerusalemInstitute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, The Hebrew University of JerusalemInstitute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, The Hebrew University of JerusalemDepartment of Dermatology, Hadassah Medical Center, The Faculty of Medicine, The Hebrew University of JerusalemInstitute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, The Hebrew University of JerusalemBacteriophage therapy is evolving as a promising approach to tackling bacterial infection, even in the case of emerging antibiotic resistance. In this work, authors present the topical application of numerous Cutibacterium acnes phage in an in vivo mouse model of acne vulgaris.https://doi.org/10.1038/s41467-023-36694-8
spellingShingle Amit Rimon
Chani Rakov
Vanda Lerer
Sivan Sheffer-Levi
Sivan Alkalay Oren
Tehila Shlomov
Lihi Shasha
Ruth Lubin
Khaled Zubeidat
Nora Jaber
Musa Mujahed
Asaf Wilensky
Shunit Coppenhagen-Glazer
Vered Molho-Pessach
Ronen Hazan
Topical phage therapy in a mouse model of Cutibacterium acnes-induced acne-like lesions
Nature Communications
title Topical phage therapy in a mouse model of Cutibacterium acnes-induced acne-like lesions
title_full Topical phage therapy in a mouse model of Cutibacterium acnes-induced acne-like lesions
title_fullStr Topical phage therapy in a mouse model of Cutibacterium acnes-induced acne-like lesions
title_full_unstemmed Topical phage therapy in a mouse model of Cutibacterium acnes-induced acne-like lesions
title_short Topical phage therapy in a mouse model of Cutibacterium acnes-induced acne-like lesions
title_sort topical phage therapy in a mouse model of cutibacterium acnes induced acne like lesions
url https://doi.org/10.1038/s41467-023-36694-8
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