Point-of-Care Screening for Coeliac Disease in Schoolchildren Reveals Higher Disease Prevalence in Croatia
Coeliac disease (CD) is an immune-mediated inflammatory disease triggered by dietary gluten and related proteins in genetically predisposed individuals. Point-of-care (POC) methods are non-invasive and easily performed tests, which could help to reduce the diagnostic delay of CD. The aim of our stud...
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MDPI AG
2022-12-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/11/1/64 |
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| author | Mario Mašić Vera Musil Tatjana Petričević Vidović Enida Sičaja Iva Hojsak Oleg Jadrešin Sanja Kolaček Zrinjka Mišak |
| author_facet | Mario Mašić Vera Musil Tatjana Petričević Vidović Enida Sičaja Iva Hojsak Oleg Jadrešin Sanja Kolaček Zrinjka Mišak |
| author_sort | Mario Mašić |
| collection | DOAJ |
| description | Coeliac disease (CD) is an immune-mediated inflammatory disease triggered by dietary gluten and related proteins in genetically predisposed individuals. Point-of-care (POC) methods are non-invasive and easily performed tests, which could help to reduce the diagnostic delay of CD. The aim of our study was to determine the prevalence of CD using rapid POC test in first-grade schoolchildren in Zagreb, Croatia. A rapid qualitative immunoassay POC test designed for detection of immunoglobulin (Ig) A and IgG deamidated gliadin antibodies (DGP), as well as total IgA (to identify IgA deficient patients) in whole blood, was used to test healthy children on gluten containing diet. Out of 1404 tested children (51% female), 85 (6.05%) had a positive rapid POC test result and were referred to paediatric gastroenterologist. Finally, 7 children were diagnosed with CD (0.5%). There was no significant difference in children with CD and children with positive POC but negative serology in sex, BMI, or symptoms. However, children diagnosed with CD complained of abdominal pain significantly more often. The prevalence of CD in first-grade schoolchildren was 1:200 (0.5%), higher than in previous studies performed in Croatia. The results imply the possible benefit of IgA and IgG DGP-based POC tests in population screening. |
| first_indexed | 2024-03-11T10:00:52Z |
| format | Article |
| id | doaj.art-6ef81392e7fb4bafa1ffb415de113352 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-11T10:00:52Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-6ef81392e7fb4bafa1ffb415de1133522023-11-16T15:25:03ZengMDPI AGHealthcare2227-90322022-12-011116410.3390/healthcare11010064Point-of-Care Screening for Coeliac Disease in Schoolchildren Reveals Higher Disease Prevalence in CroatiaMario Mašić0Vera Musil1Tatjana Petričević Vidović2Enida Sičaja3Iva Hojsak4Oleg Jadrešin5Sanja Kolaček6Zrinjka Mišak7Children’s Hospital Zagreb, Referral Centre for Paediatric Gastroenterology, Hepatology and Nutrition, 10000 Zagreb, CroatiaUniversity of Zagreb, School of Medicine, 10000 Zagreb, CroatiaAndrija Štampar Teaching Institute of Public Health, Department of School and Adolescent Medicine, 10000 Zagreb, CroatiaAndrija Štampar Teaching Institute of Public Health, Department of School and Adolescent Medicine, 10000 Zagreb, CroatiaChildren’s Hospital Zagreb, Referral Centre for Paediatric Gastroenterology, Hepatology and Nutrition, 10000 Zagreb, CroatiaChildren’s Hospital Zagreb, Referral Centre for Paediatric Gastroenterology, Hepatology and Nutrition, 10000 Zagreb, CroatiaChildren’s Hospital Zagreb, Referral Centre for Paediatric Gastroenterology, Hepatology and Nutrition, 10000 Zagreb, CroatiaChildren’s Hospital Zagreb, Referral Centre for Paediatric Gastroenterology, Hepatology and Nutrition, 10000 Zagreb, CroatiaCoeliac disease (CD) is an immune-mediated inflammatory disease triggered by dietary gluten and related proteins in genetically predisposed individuals. Point-of-care (POC) methods are non-invasive and easily performed tests, which could help to reduce the diagnostic delay of CD. The aim of our study was to determine the prevalence of CD using rapid POC test in first-grade schoolchildren in Zagreb, Croatia. A rapid qualitative immunoassay POC test designed for detection of immunoglobulin (Ig) A and IgG deamidated gliadin antibodies (DGP), as well as total IgA (to identify IgA deficient patients) in whole blood, was used to test healthy children on gluten containing diet. Out of 1404 tested children (51% female), 85 (6.05%) had a positive rapid POC test result and were referred to paediatric gastroenterologist. Finally, 7 children were diagnosed with CD (0.5%). There was no significant difference in children with CD and children with positive POC but negative serology in sex, BMI, or symptoms. However, children diagnosed with CD complained of abdominal pain significantly more often. The prevalence of CD in first-grade schoolchildren was 1:200 (0.5%), higher than in previous studies performed in Croatia. The results imply the possible benefit of IgA and IgG DGP-based POC tests in population screening.https://www.mdpi.com/2227-9032/11/1/64coeliac diseaseepidemiologychildpoint-of-care testing |
| spellingShingle | Mario Mašić Vera Musil Tatjana Petričević Vidović Enida Sičaja Iva Hojsak Oleg Jadrešin Sanja Kolaček Zrinjka Mišak Point-of-Care Screening for Coeliac Disease in Schoolchildren Reveals Higher Disease Prevalence in Croatia Healthcare coeliac disease epidemiology child point-of-care testing |
| title | Point-of-Care Screening for Coeliac Disease in Schoolchildren Reveals Higher Disease Prevalence in Croatia |
| title_full | Point-of-Care Screening for Coeliac Disease in Schoolchildren Reveals Higher Disease Prevalence in Croatia |
| title_fullStr | Point-of-Care Screening for Coeliac Disease in Schoolchildren Reveals Higher Disease Prevalence in Croatia |
| title_full_unstemmed | Point-of-Care Screening for Coeliac Disease in Schoolchildren Reveals Higher Disease Prevalence in Croatia |
| title_short | Point-of-Care Screening for Coeliac Disease in Schoolchildren Reveals Higher Disease Prevalence in Croatia |
| title_sort | point of care screening for coeliac disease in schoolchildren reveals higher disease prevalence in croatia |
| topic | coeliac disease epidemiology child point-of-care testing |
| url | https://www.mdpi.com/2227-9032/11/1/64 |
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