Spurious laboratory results associated with immunoglobulin M gammopathy in a dog with multiple myeloma
Abstract An 11 year old female‐neutered Labrador presented for facial swelling. Clinicopathological abnormalities included hyperglobulinemia, azotemia, hypercalcemia, nonregenerative anemia, thrombocytopenia, and spurious hypoglycemia. Normoglycemia was subsequently confirmed using a cage‐side analy...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16540 |
| _version_ | 1797976857489965056 |
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| author | Samantha C. Loane Daniel A. Castillo Anne‐Lorraine D. M. Peschard Harriet R. Hall Andre J. Kortum |
| author_facet | Samantha C. Loane Daniel A. Castillo Anne‐Lorraine D. M. Peschard Harriet R. Hall Andre J. Kortum |
| author_sort | Samantha C. Loane |
| collection | DOAJ |
| description | Abstract An 11 year old female‐neutered Labrador presented for facial swelling. Clinicopathological abnormalities included hyperglobulinemia, azotemia, hypercalcemia, nonregenerative anemia, thrombocytopenia, and spurious hypoglycemia. Normoglycemia was subsequently confirmed using a cage‐side analyzer (AlphaTRAK, Zoetis, UK). Serum and urine protein electrophoresis documented monoclonal (immunoglobulin M) gammopathy with Bence‐Jones proteinuria. Computed tomography imaging revealed a monostotic osteolytic bone‐lesion, and bone marrow cytology and histopathology documented plasmacytosis with multiple myeloma oncogene 1 / interferon regulatory factor 4 positivity, consistent with multiple myeloma. Infectious disease testing initially indicated seropositivity for Leishmania, Borrelia, and Anaplasma spp.; however, Leishmania PCR (splenic and bone marrow aspirates), and paired serological titers for Borrelia and Anaplasma were negative. Consequently, initial serological results were considered to be false positive because of paraproteinemia‐associated assay interference. Chemotherapy (prednisolone and melphalan combination therapy) was initiated, but the dog was euthanased 30 days later because of the development of pericardial effusion. This is a report of spurious serological (and other laboratory) results occurring secondary to monoclonal gammopathy in a dog. |
| first_indexed | 2024-04-11T04:57:39Z |
| format | Article |
| id | doaj.art-6ef88fc961114db89436992a745ed05a |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-11T04:57:39Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-6ef88fc961114db89436992a745ed05a2022-12-26T07:32:24ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762022-11-013662181218610.1111/jvim.16540Spurious laboratory results associated with immunoglobulin M gammopathy in a dog with multiple myelomaSamantha C. Loane0Daniel A. Castillo1Anne‐Lorraine D. M. Peschard2Harriet R. Hall3Andre J. Kortum4Department of Veterinary Medicine University of Cambridge Cambridge Madingley Road United KingdomDepartment of Veterinary Medicine University of Cambridge Cambridge Madingley Road United KingdomDepartment of Veterinary Medicine University of Cambridge Cambridge Madingley Road United KingdomDepartment of Veterinary Medicine University of Cambridge Cambridge Madingley Road United KingdomDepartment of Veterinary Medicine University of Cambridge Cambridge Madingley Road United KingdomAbstract An 11 year old female‐neutered Labrador presented for facial swelling. Clinicopathological abnormalities included hyperglobulinemia, azotemia, hypercalcemia, nonregenerative anemia, thrombocytopenia, and spurious hypoglycemia. Normoglycemia was subsequently confirmed using a cage‐side analyzer (AlphaTRAK, Zoetis, UK). Serum and urine protein electrophoresis documented monoclonal (immunoglobulin M) gammopathy with Bence‐Jones proteinuria. Computed tomography imaging revealed a monostotic osteolytic bone‐lesion, and bone marrow cytology and histopathology documented plasmacytosis with multiple myeloma oncogene 1 / interferon regulatory factor 4 positivity, consistent with multiple myeloma. Infectious disease testing initially indicated seropositivity for Leishmania, Borrelia, and Anaplasma spp.; however, Leishmania PCR (splenic and bone marrow aspirates), and paired serological titers for Borrelia and Anaplasma were negative. Consequently, initial serological results were considered to be false positive because of paraproteinemia‐associated assay interference. Chemotherapy (prednisolone and melphalan combination therapy) was initiated, but the dog was euthanased 30 days later because of the development of pericardial effusion. This is a report of spurious serological (and other laboratory) results occurring secondary to monoclonal gammopathy in a dog.https://doi.org/10.1111/jvim.16540false‐positivehypoglycemiaparaproteinserology |
| spellingShingle | Samantha C. Loane Daniel A. Castillo Anne‐Lorraine D. M. Peschard Harriet R. Hall Andre J. Kortum Spurious laboratory results associated with immunoglobulin M gammopathy in a dog with multiple myeloma Journal of Veterinary Internal Medicine false‐positive hypoglycemia paraprotein serology |
| title | Spurious laboratory results associated with immunoglobulin M gammopathy in a dog with multiple myeloma |
| title_full | Spurious laboratory results associated with immunoglobulin M gammopathy in a dog with multiple myeloma |
| title_fullStr | Spurious laboratory results associated with immunoglobulin M gammopathy in a dog with multiple myeloma |
| title_full_unstemmed | Spurious laboratory results associated with immunoglobulin M gammopathy in a dog with multiple myeloma |
| title_short | Spurious laboratory results associated with immunoglobulin M gammopathy in a dog with multiple myeloma |
| title_sort | spurious laboratory results associated with immunoglobulin m gammopathy in a dog with multiple myeloma |
| topic | false‐positive hypoglycemia paraprotein serology |
| url | https://doi.org/10.1111/jvim.16540 |
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