Neural activity patterns in the chemosensory network encoding vomeronasal and olfactory information in mice
Rodents detect chemical information mainly through the olfactory and vomeronasal systems, which play complementary roles to orchestrate appropriate behavioral responses. To characterize the integration of chemosensory information, we have performed electrophysiological and c-Fos studies of the bulbo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Neuroanatomy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnana.2022.988015/full |
| _version_ | 1818038475855757312 |
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| author | Cecília Pardo-Bellver Manuel E. Vila-Martin Manuel E. Vila-Martin Sergio Martínez-Bellver María Villafranca-Faus Anna Teruel-Sanchis Anna Teruel-Sanchis Camila A. Savarelli-Balsamo Camila A. Savarelli-Balsamo Sylwia M. Drabik Sylwia M. Drabik Joana Martínez-Ricós Ana Cervera-Ferri Fernando Martínez-García Enrique Lanuza Vicent Teruel-Martí |
| author_facet | Cecília Pardo-Bellver Manuel E. Vila-Martin Manuel E. Vila-Martin Sergio Martínez-Bellver María Villafranca-Faus Anna Teruel-Sanchis Anna Teruel-Sanchis Camila A. Savarelli-Balsamo Camila A. Savarelli-Balsamo Sylwia M. Drabik Sylwia M. Drabik Joana Martínez-Ricós Ana Cervera-Ferri Fernando Martínez-García Enrique Lanuza Vicent Teruel-Martí |
| author_sort | Cecília Pardo-Bellver |
| collection | DOAJ |
| description | Rodents detect chemical information mainly through the olfactory and vomeronasal systems, which play complementary roles to orchestrate appropriate behavioral responses. To characterize the integration of chemosensory information, we have performed electrophysiological and c-Fos studies of the bulbo–amygdalar network in freely behaving female mice exploring neutral or conspecific stimuli. We hypothesize that processing conspecifics stimuli requires both chemosensory systems, and thus our results will show shared patterns of activity in olfactory and vomeronasal structures. Were the hypothesis not true, the activity of the vomeronasal structures would be independent of that of the main olfactory system. In the c-Fos analysis, we assessed the activation elicited by neutral olfactory or male stimuli in a broader network. Male urine induced a significantly higher activity in the vomeronasal system compared to that induced by a neutral odorant. Concerning the olfactory system, only the cortex–amygdala transition area showed significant activation. No differential c-Fos expression was found in the reward system and the basolateral amygdala. These functional patterns in the chemosensory circuitry reveal a strong top-down control of the amygdala over both olfactory bulbs, suggesting an active role of the amygdala in the integration of chemosensory information directing the activity of the bulbs during environmental exploration. |
| first_indexed | 2024-12-10T07:43:20Z |
| format | Article |
| id | doaj.art-6ef981a963c64fef881b777539e57335 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-10T07:43:20Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-6ef981a963c64fef881b777539e573352022-12-22T01:57:15ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292022-09-011610.3389/fnana.2022.988015988015Neural activity patterns in the chemosensory network encoding vomeronasal and olfactory information in miceCecília Pardo-Bellver0Manuel E. Vila-Martin1Manuel E. Vila-Martin2Sergio Martínez-Bellver3María Villafranca-Faus4Anna Teruel-Sanchis5Anna Teruel-Sanchis6Camila A. Savarelli-Balsamo7Camila A. Savarelli-Balsamo8Sylwia M. Drabik9Sylwia M. Drabik10Joana Martínez-Ricós11Ana Cervera-Ferri12Fernando Martínez-García13Enrique Lanuza14Vicent Teruel-Martí15Department of Functional and Cell Biology, Faculty of Biology, University of Valencia, Valencia, SpainDepartment of Functional and Cell Biology, Faculty of Biology, University of Valencia, Valencia, SpainLaboratory of Neuronal Circuits, Department of Human Anatomy and Embryology, Faculty of Medicine, University of Valencia, Valencia, SpainLaboratory of Neuronal Circuits, Department of Human Anatomy and Embryology, Faculty of Medicine, University of Valencia, Valencia, SpainLaboratory of Neuronal Circuits, Department of Human Anatomy and Embryology, Faculty of Medicine, University of Valencia, Valencia, SpainDepartment of Functional and Cell Biology, Faculty of Biology, University of Valencia, Valencia, SpainLaboratory of Neuronal Circuits, Department of Human Anatomy and Embryology, Faculty of Medicine, University of Valencia, Valencia, SpainDepartment of Functional and Cell Biology, Faculty of Biology, University of Valencia, Valencia, SpainLaboratory of Neuronal Circuits, Department of Human Anatomy and Embryology, Faculty of Medicine, University of Valencia, Valencia, SpainDepartment of Functional and Cell Biology, Faculty of Biology, University of Valencia, Valencia, SpainDepartment of Neurophysiology and Chronobiology, Institute of Zoology, Jagiellonian University, Kraków, PolandLaboratory of Neuronal Circuits, Department of Human Anatomy and Embryology, Faculty of Medicine, University of Valencia, Valencia, SpainLaboratory of Neuronal Circuits, Department of Human Anatomy and Embryology, Faculty of Medicine, University of Valencia, Valencia, SpainFaculty of Health Sciences, Pre-Departmental Unit of Medicine, Jaume I University, Castellón de la Plana, SpainDepartment of Functional and Cell Biology, Faculty of Biology, University of Valencia, Valencia, SpainLaboratory of Neuronal Circuits, Department of Human Anatomy and Embryology, Faculty of Medicine, University of Valencia, Valencia, SpainRodents detect chemical information mainly through the olfactory and vomeronasal systems, which play complementary roles to orchestrate appropriate behavioral responses. To characterize the integration of chemosensory information, we have performed electrophysiological and c-Fos studies of the bulbo–amygdalar network in freely behaving female mice exploring neutral or conspecific stimuli. We hypothesize that processing conspecifics stimuli requires both chemosensory systems, and thus our results will show shared patterns of activity in olfactory and vomeronasal structures. Were the hypothesis not true, the activity of the vomeronasal structures would be independent of that of the main olfactory system. In the c-Fos analysis, we assessed the activation elicited by neutral olfactory or male stimuli in a broader network. Male urine induced a significantly higher activity in the vomeronasal system compared to that induced by a neutral odorant. Concerning the olfactory system, only the cortex–amygdala transition area showed significant activation. No differential c-Fos expression was found in the reward system and the basolateral amygdala. These functional patterns in the chemosensory circuitry reveal a strong top-down control of the amygdala over both olfactory bulbs, suggesting an active role of the amygdala in the integration of chemosensory information directing the activity of the bulbs during environmental exploration.https://www.frontiersin.org/articles/10.3389/fnana.2022.988015/fullamygdalaGranger causalityaccessory olfactory systemoscillationsc-Fos |
| spellingShingle | Cecília Pardo-Bellver Manuel E. Vila-Martin Manuel E. Vila-Martin Sergio Martínez-Bellver María Villafranca-Faus Anna Teruel-Sanchis Anna Teruel-Sanchis Camila A. Savarelli-Balsamo Camila A. Savarelli-Balsamo Sylwia M. Drabik Sylwia M. Drabik Joana Martínez-Ricós Ana Cervera-Ferri Fernando Martínez-García Enrique Lanuza Vicent Teruel-Martí Neural activity patterns in the chemosensory network encoding vomeronasal and olfactory information in mice Frontiers in Neuroanatomy amygdala Granger causality accessory olfactory system oscillations c-Fos |
| title | Neural activity patterns in the chemosensory network encoding vomeronasal and olfactory information in mice |
| title_full | Neural activity patterns in the chemosensory network encoding vomeronasal and olfactory information in mice |
| title_fullStr | Neural activity patterns in the chemosensory network encoding vomeronasal and olfactory information in mice |
| title_full_unstemmed | Neural activity patterns in the chemosensory network encoding vomeronasal and olfactory information in mice |
| title_short | Neural activity patterns in the chemosensory network encoding vomeronasal and olfactory information in mice |
| title_sort | neural activity patterns in the chemosensory network encoding vomeronasal and olfactory information in mice |
| topic | amygdala Granger causality accessory olfactory system oscillations c-Fos |
| url | https://www.frontiersin.org/articles/10.3389/fnana.2022.988015/full |
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