GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors
Several neurological and psychiatric disorders have been associated with impairments in GABAergic inhibitory neurons in the brain. Thus, in the current era of accelerated development of molecular medicine and biologically-based drugs, there is a need to identify gene regulatory sequences that can be...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.745159/full |
| _version_ | 1818735863768547328 |
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| author | Robert Duba-Kiss Yosuke Niibori David R. Hampson David R. Hampson |
| author_facet | Robert Duba-Kiss Yosuke Niibori David R. Hampson David R. Hampson |
| author_sort | Robert Duba-Kiss |
| collection | DOAJ |
| description | Several neurological and psychiatric disorders have been associated with impairments in GABAergic inhibitory neurons in the brain. Thus, in the current era of accelerated development of molecular medicine and biologically-based drugs, there is a need to identify gene regulatory sequences that can be utilized for selectively manipulating the expression of nucleic acids and proteins in GABAergic neurons. This is particularly important for the use of viral vectors in gene therapy. In this Mini Review, we discuss the use of various gene regulatory elements for targeting GABAergic neurons, with an emphasis on adeno-associated viral vectors, the most widely used class of viral vectors for treating brain diseases. |
| first_indexed | 2024-12-18T00:28:01Z |
| format | Article |
| id | doaj.art-6efa64b71cd14295b4e1a8a6bf4a6dca |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-18T00:28:01Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-6efa64b71cd14295b4e1a8a6bf4a6dca2022-12-21T21:27:11ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-10-011210.3389/fneur.2021.745159745159GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral VectorsRobert Duba-Kiss0Yosuke Niibori1David R. Hampson2David R. Hampson3Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, CanadaDepartment of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, CanadaSeveral neurological and psychiatric disorders have been associated with impairments in GABAergic inhibitory neurons in the brain. Thus, in the current era of accelerated development of molecular medicine and biologically-based drugs, there is a need to identify gene regulatory sequences that can be utilized for selectively manipulating the expression of nucleic acids and proteins in GABAergic neurons. This is particularly important for the use of viral vectors in gene therapy. In this Mini Review, we discuss the use of various gene regulatory elements for targeting GABAergic neurons, with an emphasis on adeno-associated viral vectors, the most widely used class of viral vectors for treating brain diseases.https://www.frontiersin.org/articles/10.3389/fneur.2021.745159/fullenhancerGABAgene therapyinterneuronpromoterviral vector |
| spellingShingle | Robert Duba-Kiss Yosuke Niibori David R. Hampson David R. Hampson GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors Frontiers in Neurology enhancer GABA gene therapy interneuron promoter viral vector |
| title | GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors |
| title_full | GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors |
| title_fullStr | GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors |
| title_full_unstemmed | GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors |
| title_short | GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors |
| title_sort | gabaergic gene regulatory elements used in adeno associated viral vectors |
| topic | enhancer GABA gene therapy interneuron promoter viral vector |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.745159/full |
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