TOXOPLASMOSIS AS AN OPPORTUNISTIC PROTOZOAN INFESTATION AND ITS SIGNIFICANCE IN TRANSPLANTATION
The pathogen of toxoplasmosis called Toxoplasma gondii is able to persist for a long time in various human tissues. Toxoplasmosis is referred to as an opportunistic disease, since it presents a danger to the life of the patient for the immune dysfunction. Reactivation of latent infestation in HIV in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2016-01-01
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| Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/596 |
| _version_ | 1797872003060858880 |
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| author | D. B. Goncharov N. I. Gabrielyan E. V. Abbazova E. S. Ievleva T. V. Krupenio |
| author_facet | D. B. Goncharov N. I. Gabrielyan E. V. Abbazova E. S. Ievleva T. V. Krupenio |
| author_sort | D. B. Goncharov |
| collection | DOAJ |
| description | The pathogen of toxoplasmosis called Toxoplasma gondii is able to persist for a long time in various human tissues. Toxoplasmosis is referred to as an opportunistic disease, since it presents a danger to the life of the patient for the immune dysfunction. Reactivation of latent infestation in HIV infection and transplantation procedures is a serious problem for healthcare. If a dominant clinical form in patients with HIV infection is represented by cerebral toxoplasmosis, then a broader range of lesions is observed after organ transplantation. Toxoplasmosis myocarditis and pericarditis are reliably more frequently observed. This paper analyzes mortality rate in transplantation of various organs, timing of invasive reactivation in the postoperative period and relation between reactivation and withdrawal of preventive drugs. Objectively it is rather difficult to diagnose the disease due to inaccessibility of the pathogen, atypical clinical picture and low sensitivity of laboratory indication methods. In this regard, there is a useful experience of foreign and domestic research studies in searching and using clinical, instrumental, immunological and molecular criteria of reactivation of toxoplasmosis in human immunodeficiency. The given facts convincingly demonstrated the danger of toxoplasmosis; the role of the disease is shown for various fields of medicine, particularly in transplantation of organs and tissues. |
| first_indexed | 2024-04-10T00:53:00Z |
| format | Article |
| id | doaj.art-6efc73c94e7d44cead55e126f840e62e |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2024-04-10T00:53:00Z |
| publishDate | 2016-01-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Vestnik Transplantologii i Iskusstvennyh Organov |
| spelling | doaj.art-6efc73c94e7d44cead55e126f840e62e2023-03-13T10:37:23ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovVestnik Transplantologii i Iskusstvennyh Organov1995-11912016-01-011749510310.15825/1995-1191-2015-4-95-103511TOXOPLASMOSIS AS AN OPPORTUNISTIC PROTOZOAN INFESTATION AND ITS SIGNIFICANCE IN TRANSPLANTATIOND. B. Goncharov0N. I. Gabrielyan1E. V. Abbazova2E. S. Ievleva3T. V. Krupenio4N.F. Gamaleya Federal Research Center of Epidemiology and Microbiology of the Ministry of Healthcare of Russian Federation, Moscow, Russian FederationV.I. Shumakov Federal Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation, Moscow, Russian FederationN.F. Gamaleya Federal Research Center of Epidemiology and Microbiology of the Ministry of Healthcare of Russian Federation, Moscow, Russian FederationN.F. Gamaleya Federal Research Center of Epidemiology and Microbiology of the Ministry of Healthcare of Russian Federation, Moscow, Russian FederationV.I. Shumakov Federal Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation, Moscow, Russian FederationThe pathogen of toxoplasmosis called Toxoplasma gondii is able to persist for a long time in various human tissues. Toxoplasmosis is referred to as an opportunistic disease, since it presents a danger to the life of the patient for the immune dysfunction. Reactivation of latent infestation in HIV infection and transplantation procedures is a serious problem for healthcare. If a dominant clinical form in patients with HIV infection is represented by cerebral toxoplasmosis, then a broader range of lesions is observed after organ transplantation. Toxoplasmosis myocarditis and pericarditis are reliably more frequently observed. This paper analyzes mortality rate in transplantation of various organs, timing of invasive reactivation in the postoperative period and relation between reactivation and withdrawal of preventive drugs. Objectively it is rather difficult to diagnose the disease due to inaccessibility of the pathogen, atypical clinical picture and low sensitivity of laboratory indication methods. In this regard, there is a useful experience of foreign and domestic research studies in searching and using clinical, instrumental, immunological and molecular criteria of reactivation of toxoplasmosis in human immunodeficiency. The given facts convincingly demonstrated the danger of toxoplasmosis; the role of the disease is shown for various fields of medicine, particularly in transplantation of organs and tissues.https://journal.transpl.ru/vtio/article/view/596toxoplasmosistoxoplasma gondiitransplantationrecipient of organsimmunosuppressionhiv infectionantibodiesreactivation |
| spellingShingle | D. B. Goncharov N. I. Gabrielyan E. V. Abbazova E. S. Ievleva T. V. Krupenio TOXOPLASMOSIS AS AN OPPORTUNISTIC PROTOZOAN INFESTATION AND ITS SIGNIFICANCE IN TRANSPLANTATION Vestnik Transplantologii i Iskusstvennyh Organov toxoplasmosis toxoplasma gondii transplantation recipient of organs immunosuppression hiv infection antibodies reactivation |
| title | TOXOPLASMOSIS AS AN OPPORTUNISTIC PROTOZOAN INFESTATION AND ITS SIGNIFICANCE IN TRANSPLANTATION |
| title_full | TOXOPLASMOSIS AS AN OPPORTUNISTIC PROTOZOAN INFESTATION AND ITS SIGNIFICANCE IN TRANSPLANTATION |
| title_fullStr | TOXOPLASMOSIS AS AN OPPORTUNISTIC PROTOZOAN INFESTATION AND ITS SIGNIFICANCE IN TRANSPLANTATION |
| title_full_unstemmed | TOXOPLASMOSIS AS AN OPPORTUNISTIC PROTOZOAN INFESTATION AND ITS SIGNIFICANCE IN TRANSPLANTATION |
| title_short | TOXOPLASMOSIS AS AN OPPORTUNISTIC PROTOZOAN INFESTATION AND ITS SIGNIFICANCE IN TRANSPLANTATION |
| title_sort | toxoplasmosis as an opportunistic protozoan infestation and its significance in transplantation |
| topic | toxoplasmosis toxoplasma gondii transplantation recipient of organs immunosuppression hiv infection antibodies reactivation |
| url | https://journal.transpl.ru/vtio/article/view/596 |
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