Insulin induces relaxation and decreases hydrogen peroxide-induced vasoconstriction in human placental vascular bed in a mechanism mediated by calcium-activated potassium channels and L-arginine/nitric oxide pathways.

Insulin induces relaxation and decreases hydrogen peroxide-induced vasoconstriction in human placental vascular bed in a mechanism mediated by calcium-activated potassium channels and L-arginine/nitric oxide pathways.

Insulin induces relaxation in umbilical veins, increasing the expression of human amino acid transporter 1 (hCAT-1) and nitric oxide synthesis (NO) in human umbilical vein endothelial cells (HUVECs). Short-term effects of insulin on vasculature have been reported in healthy subjects and cell culture...

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Bibliographic Details
Main Authors: Lissette Cabrera, Andrea Saavedra, Susana Rojas, Marcela Cid, Cristina Valenzuela, David Alejandro Gallegos Rozas, Pamela Careaga, Emerita Basualto, Astrid Haensgen, Eduardo Peña, Coralia Rivas, Juan Carlos Vera, Victoria Gallardo, Leandro Zuniga, Carlos Alonso Escudero, Luis Sobrevia, Mark Wareing, Marcelo González
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Physiology
Subjects:
Insulin
Nitric Oxide
Placenta
L-arginine
BKCa channels
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00529/full

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