Engineering of biomimetic mineralized layer formed on the surface of natural dental enamel
The problem of engineering a biomimetic mineralized layer on the surface of native dental tissue (bio-template) was considered in our work.The formation of the mineralized layer on a biotemplate is achieved with the use of nanocrystalline carbonate-substituted calcium hydroxyapatite (HAp), calcium a...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Results in Engineering |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590123022002535 |
| _version_ | 1811210567064485888 |
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| author | Pavel Seredin Dmitry Goloshchapov Anna Emelyanova Nikita Buylov Vladimir Kashkarov Anatoly Lukin Yuri Ippolitov Tatiana Khmelevskaia Iman A. Mahdy Manal A. Mahdy |
| author_facet | Pavel Seredin Dmitry Goloshchapov Anna Emelyanova Nikita Buylov Vladimir Kashkarov Anatoly Lukin Yuri Ippolitov Tatiana Khmelevskaia Iman A. Mahdy Manal A. Mahdy |
| author_sort | Pavel Seredin |
| collection | DOAJ |
| description | The problem of engineering a biomimetic mineralized layer on the surface of native dental tissue (bio-template) was considered in our work.The formation of the mineralized layer on a biotemplate is achieved with the use of nanocrystalline carbonate-substituted calcium hydroxyapatite (HAp), calcium alkali, and a complex of polyfunctional organic and polar amino acids.By applying the set of structural and spectroscopic methods of analysis we have confirmed the formation of a mineralized biomimetic HAp layer on the surface of bio-template with properties resembling those of natural hard tissue. The thickness of the biomimetic mineralized layer varies from 300 to 500 nm, while the direction of some ncHAp nanocrystals coincides with that of the apatite crystals in the enamel.We also demonstrated that the engineered mineralized HAp layer was characterized by homogeneous micromorphology and enhanced nanohardness in the region of the enamel rods exceeding those of native enamel.The development of a strategy for biomimetic engineering and a technique for enamel surface pre-treatment to enable tissue mineralization has huge potential in dental applications. |
| first_indexed | 2024-04-12T04:58:06Z |
| format | Article |
| id | doaj.art-6efcadfcf68e4005baaf84cd36ad3663 |
| institution | Directory Open Access Journal |
| issn | 2590-1230 |
| language | English |
| last_indexed | 2024-04-12T04:58:06Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Engineering |
| spelling | doaj.art-6efcadfcf68e4005baaf84cd36ad36632022-12-22T03:47:04ZengElsevierResults in Engineering2590-12302022-09-0115100583Engineering of biomimetic mineralized layer formed on the surface of natural dental enamelPavel Seredin0Dmitry Goloshchapov1Anna Emelyanova2Nikita Buylov3Vladimir Kashkarov4Anatoly Lukin5Yuri Ippolitov6Tatiana Khmelevskaia7Iman A. Mahdy8Manal A. Mahdy9Solid State Physics and Nanostructures Department, Voronezh State University, University sq.1, 394018 Voronezh, Russia; Scientific and Educational Center “Nanomaterials and Nanotechnologies”, Ural Federal University, Mir av., 620002 Yekaterinburg, Russia; Corresponding author. Solid State Physics and Nanostructures Department, Voronezh State University, University sq.1, 394018 Voronezh, Russia.Solid State Physics and Nanostructures Department, Voronezh State University, University sq.1, 394018 Voronezh, RussiaSolid State Physics and Nanostructures Department, Voronezh State University, University sq.1, 394018 Voronezh, RussiaSolid State Physics and Nanostructures Department, Voronezh State University, University sq.1, 394018 Voronezh, RussiaSolid State Physics and Nanostructures Department, Voronezh State University, University sq.1, 394018 Voronezh, RussiaSolid State Physics and Nanostructures Department, Voronezh State University, University sq.1, 394018 Voronezh, RussiaDepartment of Pediatric Dentistry with Orthodontia, Voronezh State Medical University, Studentcheskaya st. 11, 394006 Voronezh, RussiaDepartment of Pediatric Dentistry with Orthodontia, Voronezh State Medical University, Studentcheskaya st. 11, 394006 Voronezh, RussiaPhysics Department, Faculty of Science (Girls), Al-Azhar University, 11754 Nasr City, Cairo, EgyptSolid State Physics Department, National Research Centre, 12622 Dokki, Giza, EgyptThe problem of engineering a biomimetic mineralized layer on the surface of native dental tissue (bio-template) was considered in our work.The formation of the mineralized layer on a biotemplate is achieved with the use of nanocrystalline carbonate-substituted calcium hydroxyapatite (HAp), calcium alkali, and a complex of polyfunctional organic and polar amino acids.By applying the set of structural and spectroscopic methods of analysis we have confirmed the formation of a mineralized biomimetic HAp layer on the surface of bio-template with properties resembling those of natural hard tissue. The thickness of the biomimetic mineralized layer varies from 300 to 500 nm, while the direction of some ncHAp nanocrystals coincides with that of the apatite crystals in the enamel.We also demonstrated that the engineered mineralized HAp layer was characterized by homogeneous micromorphology and enhanced nanohardness in the region of the enamel rods exceeding those of native enamel.The development of a strategy for biomimetic engineering and a technique for enamel surface pre-treatment to enable tissue mineralization has huge potential in dental applications.http://www.sciencedirect.com/science/article/pii/S2590123022002535BiomimeticMineralizationEnamel tissueAFMFESEMmicroRaman spectromicroscopy |
| spellingShingle | Pavel Seredin Dmitry Goloshchapov Anna Emelyanova Nikita Buylov Vladimir Kashkarov Anatoly Lukin Yuri Ippolitov Tatiana Khmelevskaia Iman A. Mahdy Manal A. Mahdy Engineering of biomimetic mineralized layer formed on the surface of natural dental enamel Results in Engineering Biomimetic Mineralization Enamel tissue AFM FESEM microRaman spectromicroscopy |
| title | Engineering of biomimetic mineralized layer formed on the surface of natural dental enamel |
| title_full | Engineering of biomimetic mineralized layer formed on the surface of natural dental enamel |
| title_fullStr | Engineering of biomimetic mineralized layer formed on the surface of natural dental enamel |
| title_full_unstemmed | Engineering of biomimetic mineralized layer formed on the surface of natural dental enamel |
| title_short | Engineering of biomimetic mineralized layer formed on the surface of natural dental enamel |
| title_sort | engineering of biomimetic mineralized layer formed on the surface of natural dental enamel |
| topic | Biomimetic Mineralization Enamel tissue AFM FESEM microRaman spectromicroscopy |
| url | http://www.sciencedirect.com/science/article/pii/S2590123022002535 |
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