Alpha-fetoprotein-elevated postpubertal testicular teratoma with retroperitoneal metastasis on 18F-FDG PET/CT: case report and literature review
Postpubertal testicular teratoma exhibits malignant biological behavior and has metastatic potential. We report a case of a 17-year-old patient diagnosed with postpubertal testicular teratoma with massive retroperitoneal metastasis. The pathological examination revealed a mature teratoma without any...
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1269587/full |
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| author | Hao Jiao Yongkang Qiu Wenpeng Huang Yongbai Zhang Zhao Chen Aixiang Wang Lei Kang |
| author_facet | Hao Jiao Yongkang Qiu Wenpeng Huang Yongbai Zhang Zhao Chen Aixiang Wang Lei Kang |
| author_sort | Hao Jiao |
| collection | DOAJ |
| description | Postpubertal testicular teratoma exhibits malignant biological behavior and has metastatic potential. We report a case of a 17-year-old patient diagnosed with postpubertal testicular teratoma with massive retroperitoneal metastasis. The pathological examination revealed a mature teratoma without any other components. However, the patient had a significantly increased level of AFP, and 18F-FDG PET/CT showed the retroperitoneal metastasis had increased FDG uptake, with a SUVmax of 15.6, suggesting the coexistence of other germ cell tumor components, and the patient might have a poor prognosis. After resection of the retroperitoneal tumor, PET/CT further revealed multiple abdominal and pelvic metastases, with a SUVmax of 22.5. Therefore, the patient received a cycle of chemotherapy and follow-up PET/CT imaging showed the achievement of complete metabolic response after the treatment. In this case, PET/CT played a crucial role in detecting metastasis, compensating for the limitations of pathological sampling, thus establishing a definitive diagnosis and predicting prognosis. And it was evident that PET/CT also has the advantage of evaluating therapeutic efficacy. |
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| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-12T02:29:00Z |
| publishDate | 2023-09-01 |
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| spelling | doaj.art-6f0060b1f5d54ad9a5afbb1bb530b3db2023-09-05T10:33:25ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-09-011010.3389/fmed.2023.12695871269587Alpha-fetoprotein-elevated postpubertal testicular teratoma with retroperitoneal metastasis on 18F-FDG PET/CT: case report and literature reviewHao Jiao0Yongkang Qiu1Wenpeng Huang2Yongbai Zhang3Zhao Chen4Aixiang Wang5Lei Kang6Department of Nuclear Medicine, Peking University First Hospital, Beijing, ChinaDepartment of Nuclear Medicine, Peking University First Hospital, Beijing, ChinaDepartment of Nuclear Medicine, Peking University First Hospital, Beijing, ChinaDepartment of Nuclear Medicine, Peking University First Hospital, Beijing, ChinaDepartment of Nuclear Medicine, Peking University First Hospital, Beijing, ChinaDepartment of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing, ChinaDepartment of Nuclear Medicine, Peking University First Hospital, Beijing, ChinaPostpubertal testicular teratoma exhibits malignant biological behavior and has metastatic potential. We report a case of a 17-year-old patient diagnosed with postpubertal testicular teratoma with massive retroperitoneal metastasis. The pathological examination revealed a mature teratoma without any other components. However, the patient had a significantly increased level of AFP, and 18F-FDG PET/CT showed the retroperitoneal metastasis had increased FDG uptake, with a SUVmax of 15.6, suggesting the coexistence of other germ cell tumor components, and the patient might have a poor prognosis. After resection of the retroperitoneal tumor, PET/CT further revealed multiple abdominal and pelvic metastases, with a SUVmax of 22.5. Therefore, the patient received a cycle of chemotherapy and follow-up PET/CT imaging showed the achievement of complete metabolic response after the treatment. In this case, PET/CT played a crucial role in detecting metastasis, compensating for the limitations of pathological sampling, thus establishing a definitive diagnosis and predicting prognosis. And it was evident that PET/CT also has the advantage of evaluating therapeutic efficacy.https://www.frontiersin.org/articles/10.3389/fmed.2023.1269587/fullpostpubertal testicular teratomaretroperitoneal metastasis18F-FDGPET/CTalpha-fetoprotein |
| spellingShingle | Hao Jiao Yongkang Qiu Wenpeng Huang Yongbai Zhang Zhao Chen Aixiang Wang Lei Kang Alpha-fetoprotein-elevated postpubertal testicular teratoma with retroperitoneal metastasis on 18F-FDG PET/CT: case report and literature review Frontiers in Medicine postpubertal testicular teratoma retroperitoneal metastasis 18F-FDG PET/CT alpha-fetoprotein |
| title | Alpha-fetoprotein-elevated postpubertal testicular teratoma with retroperitoneal metastasis on 18F-FDG PET/CT: case report and literature review |
| title_full | Alpha-fetoprotein-elevated postpubertal testicular teratoma with retroperitoneal metastasis on 18F-FDG PET/CT: case report and literature review |
| title_fullStr | Alpha-fetoprotein-elevated postpubertal testicular teratoma with retroperitoneal metastasis on 18F-FDG PET/CT: case report and literature review |
| title_full_unstemmed | Alpha-fetoprotein-elevated postpubertal testicular teratoma with retroperitoneal metastasis on 18F-FDG PET/CT: case report and literature review |
| title_short | Alpha-fetoprotein-elevated postpubertal testicular teratoma with retroperitoneal metastasis on 18F-FDG PET/CT: case report and literature review |
| title_sort | alpha fetoprotein elevated postpubertal testicular teratoma with retroperitoneal metastasis on 18f fdg pet ct case report and literature review |
| topic | postpubertal testicular teratoma retroperitoneal metastasis 18F-FDG PET/CT alpha-fetoprotein |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1269587/full |
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