Adiponectin Participates in Preeclampsia by Regulating the Biological Function of Placental Trophoblasts through P38 MAPK-STAT5 Pathway
Background: We aimed to investigate the participation of adiponectin in preeclampsia, and to explore the possible mechanism. Methods: A total of 52 patients with preeclampsia and 30 normal women with full-term pregnancy were enrolled. Immunohistochemistry was used to detect the localization of MA...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2018-12-01
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| Series: | Iranian Journal of Public Health |
| Subjects: | |
| Online Access: | https://ijph.tums.ac.ir/index.php/ijph/article/view/15510 |
| _version_ | 1818984104074412032 |
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| author | Gaoxia DONG Ying TIAN Xinqin LI |
| author_facet | Gaoxia DONG Ying TIAN Xinqin LI |
| author_sort | Gaoxia DONG |
| collection | DOAJ |
| description | Background: We aimed to investigate the participation of adiponectin in preeclampsia, and to explore the possible mechanism.
Methods: A total of 52 patients with preeclampsia and 30 normal women with full-term pregnancy were enrolled. Immunohistochemistry was used to detect the localization of MAPK and STAT5. RT-PCR was used to detect the expression of adiponectin mRNA in placental tissue of patients with preeclampsia and normal pregnant women. Western blot was used to detect the expression of adiponectin protein, MAPK, p-MAPK, STAT5 and p-STAT5 in placental tissue of patients with preeclampsia and normal pregnant women.
Results: p-p38 was highly expressed in placental trophoblasts of patients with preeclampsia, while p-STAT5 was less expressed. Expression level of p-p38 and p-STAT5 in patients with preeclampsia were significantly different from those in normal pregnant women (P<0.01). Expression level of adiponectin mRNA was significantly lower in patients with preeclampsia than in normal pregnant women (P<0.05). Level of p-p38 expression was negatively correlated with levels of adiponectin expression (r=-0.413, P<0.05). Expression level of p-STAT5 was positively correlated with expression level of adiponectin (r=0.526, P<0.01).
Conclusion: Adiponectin participates in preeclampsia by regulating the biological function of placental trophoblasts through p38 MAPK-STAT5 pathway. |
| first_indexed | 2024-12-20T18:13:41Z |
| format | Article |
| id | doaj.art-6f00825daf8d41a49590dfad8d0fd3a8 |
| institution | Directory Open Access Journal |
| issn | 2251-6085 2251-6093 |
| language | English |
| last_indexed | 2024-12-20T18:13:41Z |
| publishDate | 2018-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-6f00825daf8d41a49590dfad8d0fd3a82022-12-21T19:30:25ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932018-12-014712Adiponectin Participates in Preeclampsia by Regulating the Biological Function of Placental Trophoblasts through P38 MAPK-STAT5 PathwayGaoxia DONG0Ying TIAN1Xinqin LI2Dept. of Obstetrics, The Second People’s Hospital of Liaocheng, Liaocheng 252600, ChinaDept. of Obstetrics, Zhangqiu Maternity and Child Care Hospital, Jinan 250000, ChinaDept. of Obstetrics, Jining First People’s Hospital, Jining 272011, ChinaBackground: We aimed to investigate the participation of adiponectin in preeclampsia, and to explore the possible mechanism. Methods: A total of 52 patients with preeclampsia and 30 normal women with full-term pregnancy were enrolled. Immunohistochemistry was used to detect the localization of MAPK and STAT5. RT-PCR was used to detect the expression of adiponectin mRNA in placental tissue of patients with preeclampsia and normal pregnant women. Western blot was used to detect the expression of adiponectin protein, MAPK, p-MAPK, STAT5 and p-STAT5 in placental tissue of patients with preeclampsia and normal pregnant women. Results: p-p38 was highly expressed in placental trophoblasts of patients with preeclampsia, while p-STAT5 was less expressed. Expression level of p-p38 and p-STAT5 in patients with preeclampsia were significantly different from those in normal pregnant women (P<0.01). Expression level of adiponectin mRNA was significantly lower in patients with preeclampsia than in normal pregnant women (P<0.05). Level of p-p38 expression was negatively correlated with levels of adiponectin expression (r=-0.413, P<0.05). Expression level of p-STAT5 was positively correlated with expression level of adiponectin (r=0.526, P<0.01). Conclusion: Adiponectin participates in preeclampsia by regulating the biological function of placental trophoblasts through p38 MAPK-STAT5 pathway.https://ijph.tums.ac.ir/index.php/ijph/article/view/15510AdiponectinMAPKSTAT5Preeclampsia |
| spellingShingle | Gaoxia DONG Ying TIAN Xinqin LI Adiponectin Participates in Preeclampsia by Regulating the Biological Function of Placental Trophoblasts through P38 MAPK-STAT5 Pathway Iranian Journal of Public Health Adiponectin MAPK STAT5 Preeclampsia |
| title | Adiponectin Participates in Preeclampsia by Regulating the Biological Function of Placental Trophoblasts through P38 MAPK-STAT5 Pathway |
| title_full | Adiponectin Participates in Preeclampsia by Regulating the Biological Function of Placental Trophoblasts through P38 MAPK-STAT5 Pathway |
| title_fullStr | Adiponectin Participates in Preeclampsia by Regulating the Biological Function of Placental Trophoblasts through P38 MAPK-STAT5 Pathway |
| title_full_unstemmed | Adiponectin Participates in Preeclampsia by Regulating the Biological Function of Placental Trophoblasts through P38 MAPK-STAT5 Pathway |
| title_short | Adiponectin Participates in Preeclampsia by Regulating the Biological Function of Placental Trophoblasts through P38 MAPK-STAT5 Pathway |
| title_sort | adiponectin participates in preeclampsia by regulating the biological function of placental trophoblasts through p38 mapk stat5 pathway |
| topic | Adiponectin MAPK STAT5 Preeclampsia |
| url | https://ijph.tums.ac.ir/index.php/ijph/article/view/15510 |
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