Case report: Advanced primary squamous cell carcinoma in the periampullary area with upregulation of programmed cell death-ligand 1 expression and response to sintilimab immunotherapy
Primary squamous cell carcinoma (SCC) of the periampullary area is exceedingly rare. We report a case of a 45-year-old woman who presented with progressive upper abdominal pain and melena. Laboratory testing revealed an elevated level of carcinoembryonic antigen. Esophagogastroduodenoscopy revealed...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1086760/full |
| _version_ | 1797942046533615616 |
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| author | Baoshan Wang Dazhou Li Dehua Zeng Wen Wang Wen Wang Chuanshen Jiang |
| author_facet | Baoshan Wang Dazhou Li Dehua Zeng Wen Wang Wen Wang Chuanshen Jiang |
| author_sort | Baoshan Wang |
| collection | DOAJ |
| description | Primary squamous cell carcinoma (SCC) of the periampullary area is exceedingly rare. We report a case of a 45-year-old woman who presented with progressive upper abdominal pain and melena. Laboratory testing revealed an elevated level of carcinoembryonic antigen. Esophagogastroduodenoscopy revealed a very large irregular ulcerated tumor in the periampullary area. Contrast-enhanced computed tomography (CT) of the chest, abdomen, and pelvis, 18 F-fluorodeoxyglucose positron emission tomography/CT, and thin-prep cytologic test excluded metastasis of the primary tumor to the periampullary area from other sites. Immunohistochemistry revealed positive p40 and cytokeratin (CK)5/6, indicating SCC. The expression of programmed cell death-ligand 1 (PD-L1) in tumor cells was upregulated, and the patient responded well to chemotherapy combined with immunotherapy. To the best of our knowledge, this is the first reported case of advanced primary SCC in the periampullary area with high expression of PD-L1. |
| first_indexed | 2024-04-10T20:01:28Z |
| format | Article |
| id | doaj.art-6f00cc38f36d4fd2a330ec3323a0da40 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T20:01:28Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6f00cc38f36d4fd2a330ec3323a0da402023-01-27T04:38:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011410.3389/fimmu.2023.10867601086760Case report: Advanced primary squamous cell carcinoma in the periampullary area with upregulation of programmed cell death-ligand 1 expression and response to sintilimab immunotherapyBaoshan Wang0Dazhou Li1Dehua Zeng2Wen Wang3Wen Wang4Chuanshen Jiang5Department of Gastroenterology, 900THHospital of Joint Logistics Support Force, Fujian Medical University, Fuzhou, ChinaDepartment of Gastroenterology, 900THHospital of Joint Logistics Support Force, Fujian Medical University, Fuzhou, ChinaDepartment of Pathology, 900THHospital of Joint Logistics Support Force, Fujian Medical University, Fuzhou, ChinaDepartment of Gastroenterology, 900THHospital of Joint Logistics Support Force, Fujian Medical University, Fuzhou, ChinaDepartment of Gastroenterology, 900THHospital of Joint Logistics Support Force, Oriental Hospital Affiliated to Xiamen University, Fuzhou, ChinaDepartment of Gastroenterology, 900THHospital of Joint Logistics Support Force, Fujian Medical University, Fuzhou, ChinaPrimary squamous cell carcinoma (SCC) of the periampullary area is exceedingly rare. We report a case of a 45-year-old woman who presented with progressive upper abdominal pain and melena. Laboratory testing revealed an elevated level of carcinoembryonic antigen. Esophagogastroduodenoscopy revealed a very large irregular ulcerated tumor in the periampullary area. Contrast-enhanced computed tomography (CT) of the chest, abdomen, and pelvis, 18 F-fluorodeoxyglucose positron emission tomography/CT, and thin-prep cytologic test excluded metastasis of the primary tumor to the periampullary area from other sites. Immunohistochemistry revealed positive p40 and cytokeratin (CK)5/6, indicating SCC. The expression of programmed cell death-ligand 1 (PD-L1) in tumor cells was upregulated, and the patient responded well to chemotherapy combined with immunotherapy. To the best of our knowledge, this is the first reported case of advanced primary SCC in the periampullary area with high expression of PD-L1.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1086760/fullperiampullaryprogrammed cell death-ligand 1primaryimmunotherapysintilimabsquamous cell carcinoma |
| spellingShingle | Baoshan Wang Dazhou Li Dehua Zeng Wen Wang Wen Wang Chuanshen Jiang Case report: Advanced primary squamous cell carcinoma in the periampullary area with upregulation of programmed cell death-ligand 1 expression and response to sintilimab immunotherapy Frontiers in Immunology periampullary programmed cell death-ligand 1 primary immunotherapy sintilimab squamous cell carcinoma |
| title | Case report: Advanced primary squamous cell carcinoma in the periampullary area with upregulation of programmed cell death-ligand 1 expression and response to sintilimab immunotherapy |
| title_full | Case report: Advanced primary squamous cell carcinoma in the periampullary area with upregulation of programmed cell death-ligand 1 expression and response to sintilimab immunotherapy |
| title_fullStr | Case report: Advanced primary squamous cell carcinoma in the periampullary area with upregulation of programmed cell death-ligand 1 expression and response to sintilimab immunotherapy |
| title_full_unstemmed | Case report: Advanced primary squamous cell carcinoma in the periampullary area with upregulation of programmed cell death-ligand 1 expression and response to sintilimab immunotherapy |
| title_short | Case report: Advanced primary squamous cell carcinoma in the periampullary area with upregulation of programmed cell death-ligand 1 expression and response to sintilimab immunotherapy |
| title_sort | case report advanced primary squamous cell carcinoma in the periampullary area with upregulation of programmed cell death ligand 1 expression and response to sintilimab immunotherapy |
| topic | periampullary programmed cell death-ligand 1 primary immunotherapy sintilimab squamous cell carcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1086760/full |
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