Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis
Cardiovascular development is initiated soon after gastrulation as bilateral precardiac mesoderm is progressively symmetrically determined at both sides of the developing embryo. The precardiac mesoderm subsequently fused at the embryonic midline constituting an embryonic linear heart tube. As devel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/5/2839 |
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| author | Estefania Lozano-Velasco Carlos Garcia-Padilla Maria del Mar Muñoz-Gallardo Francisco Jose Martinez-Amaro Sheila Caño-Carrillo Juan Manuel Castillo-Casas Cristina Sanchez-Fernandez Amelia E. Aranega Diego Franco |
| author_facet | Estefania Lozano-Velasco Carlos Garcia-Padilla Maria del Mar Muñoz-Gallardo Francisco Jose Martinez-Amaro Sheila Caño-Carrillo Juan Manuel Castillo-Casas Cristina Sanchez-Fernandez Amelia E. Aranega Diego Franco |
| author_sort | Estefania Lozano-Velasco |
| collection | DOAJ |
| description | Cardiovascular development is initiated soon after gastrulation as bilateral precardiac mesoderm is progressively symmetrically determined at both sides of the developing embryo. The precardiac mesoderm subsequently fused at the embryonic midline constituting an embryonic linear heart tube. As development progress, the embryonic heart displays the first sign of left-right asymmetric morphology by the invariably rightward looping of the initial heart tube and prospective embryonic ventricular and atrial chambers emerged. As cardiac development progresses, the atrial and ventricular chambers enlarged and distinct left and right compartments emerge as consequence of the formation of the interatrial and interventricular septa, respectively. The last steps of cardiac morphogenesis are represented by the completion of atrial and ventricular septation, resulting in the configuration of a double circuitry with distinct systemic and pulmonary chambers, each of them with distinct inlets and outlets connections. Over the last decade, our understanding of the contribution of multiple growth factor signaling cascades such as Tgf-beta, Bmp and Wnt signaling as well as of transcriptional regulators to cardiac morphogenesis have greatly enlarged. Recently, a novel layer of complexity has emerged with the discovery of non-coding RNAs, particularly microRNAs and lncRNAs. Herein, we provide a state-of-the-art review of the contribution of non-coding RNAs during cardiac development. microRNAs and lncRNAs have been reported to functional modulate all stages of cardiac morphogenesis, spanning from lateral plate mesoderm formation to outflow tract septation, by modulating major growth factor signaling pathways as well as those transcriptional regulators involved in cardiac development. |
| first_indexed | 2024-03-09T20:35:59Z |
| format | Article |
| id | doaj.art-6f03dcd685404b8dab211549b0d6646b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T20:35:59Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6f03dcd685404b8dab211549b0d6646b2023-11-23T23:10:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01235283910.3390/ijms23052839Post-Transcriptional Regulation of Molecular Determinants during CardiogenesisEstefania Lozano-Velasco0Carlos Garcia-Padilla1Maria del Mar Muñoz-Gallardo2Francisco Jose Martinez-Amaro3Sheila Caño-Carrillo4Juan Manuel Castillo-Casas5Cristina Sanchez-Fernandez6Amelia E. Aranega7Diego Franco8Cardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, SpainCardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, SpainCardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, SpainCardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, SpainCardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, SpainCardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, SpainCardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, SpainCardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, SpainCardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, SpainCardiovascular development is initiated soon after gastrulation as bilateral precardiac mesoderm is progressively symmetrically determined at both sides of the developing embryo. The precardiac mesoderm subsequently fused at the embryonic midline constituting an embryonic linear heart tube. As development progress, the embryonic heart displays the first sign of left-right asymmetric morphology by the invariably rightward looping of the initial heart tube and prospective embryonic ventricular and atrial chambers emerged. As cardiac development progresses, the atrial and ventricular chambers enlarged and distinct left and right compartments emerge as consequence of the formation of the interatrial and interventricular septa, respectively. The last steps of cardiac morphogenesis are represented by the completion of atrial and ventricular septation, resulting in the configuration of a double circuitry with distinct systemic and pulmonary chambers, each of them with distinct inlets and outlets connections. Over the last decade, our understanding of the contribution of multiple growth factor signaling cascades such as Tgf-beta, Bmp and Wnt signaling as well as of transcriptional regulators to cardiac morphogenesis have greatly enlarged. Recently, a novel layer of complexity has emerged with the discovery of non-coding RNAs, particularly microRNAs and lncRNAs. Herein, we provide a state-of-the-art review of the contribution of non-coding RNAs during cardiac development. microRNAs and lncRNAs have been reported to functional modulate all stages of cardiac morphogenesis, spanning from lateral plate mesoderm formation to outflow tract septation, by modulating major growth factor signaling pathways as well as those transcriptional regulators involved in cardiac development.https://www.mdpi.com/1422-0067/23/5/2839cardiac developmenttranscriptional regulationmicroRNAslncRNAs |
| spellingShingle | Estefania Lozano-Velasco Carlos Garcia-Padilla Maria del Mar Muñoz-Gallardo Francisco Jose Martinez-Amaro Sheila Caño-Carrillo Juan Manuel Castillo-Casas Cristina Sanchez-Fernandez Amelia E. Aranega Diego Franco Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis International Journal of Molecular Sciences cardiac development transcriptional regulation microRNAs lncRNAs |
| title | Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis |
| title_full | Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis |
| title_fullStr | Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis |
| title_full_unstemmed | Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis |
| title_short | Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis |
| title_sort | post transcriptional regulation of molecular determinants during cardiogenesis |
| topic | cardiac development transcriptional regulation microRNAs lncRNAs |
| url | https://www.mdpi.com/1422-0067/23/5/2839 |
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