Biosensing in dermal interstitial fluid using microneedle based electrochemical devices
This article explores recent advances in the development of electrochemical biosensors on microneedle platforms towards on-device sensing of biomarkers present in dermal interstitial fluid. The integration of a biosensor with a microneedle platform opens the possibility for minimally invasive bio-ch...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-08-01
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| Series: | Sensing and Bio-Sensing Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214180420300064 |
| _version_ | 1819145264696393728 |
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| author | Julia Madden Conor O'Mahony Michael Thompson Alan O'Riordan Paul Galvin |
| author_facet | Julia Madden Conor O'Mahony Michael Thompson Alan O'Riordan Paul Galvin |
| author_sort | Julia Madden |
| collection | DOAJ |
| description | This article explores recent advances in the development of electrochemical biosensors on microneedle platforms towards on-device sensing of biomarkers present in dermal interstitial fluid. The integration of a biosensor with a microneedle platform opens the possibility for minimally invasive bio-chemical detection or continuous monitoring within the dermal interstitial fluid. An introduction to interstitial fluid is provided placing emphasis on sampling methods that have been employed to extract and/or sample tissue fluid for analysis. We look briefly at microneedle technologies used to extract dermal interstitial fluid for subsequent analysis. Successive content will focus on microneedle technologies which have been integrated with electrochemical biosensors for the quantification of various metabolites, electrolytes and other miscellaneous entities known to be present in the dermal interstitial fluid. The review concludes with some of the key challenges and opportunities faced by this next-generation wearable sensing technology. |
| first_indexed | 2024-12-22T12:55:16Z |
| format | Article |
| id | doaj.art-6f03dee6e0974ae8b9a028f1caabfa5e |
| institution | Directory Open Access Journal |
| issn | 2214-1804 |
| language | English |
| last_indexed | 2024-12-22T12:55:16Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensing and Bio-Sensing Research |
| spelling | doaj.art-6f03dee6e0974ae8b9a028f1caabfa5e2022-12-21T18:25:08ZengElsevierSensing and Bio-Sensing Research2214-18042020-08-0129100348Biosensing in dermal interstitial fluid using microneedle based electrochemical devicesJulia Madden0Conor O'Mahony1Michael Thompson2Alan O'Riordan3Paul Galvin4Tyndall National Institute, University College Cork, Ireland; Corresponding author.Tyndall National Institute, University College Cork, IrelandDepartment of Chemistry, University of Toronto, CanadaTyndall National Institute, University College Cork, IrelandTyndall National Institute, University College Cork, IrelandThis article explores recent advances in the development of electrochemical biosensors on microneedle platforms towards on-device sensing of biomarkers present in dermal interstitial fluid. The integration of a biosensor with a microneedle platform opens the possibility for minimally invasive bio-chemical detection or continuous monitoring within the dermal interstitial fluid. An introduction to interstitial fluid is provided placing emphasis on sampling methods that have been employed to extract and/or sample tissue fluid for analysis. We look briefly at microneedle technologies used to extract dermal interstitial fluid for subsequent analysis. Successive content will focus on microneedle technologies which have been integrated with electrochemical biosensors for the quantification of various metabolites, electrolytes and other miscellaneous entities known to be present in the dermal interstitial fluid. The review concludes with some of the key challenges and opportunities faced by this next-generation wearable sensing technology.http://www.sciencedirect.com/science/article/pii/S2214180420300064Dermal interstitial fluidElectrochemicalBiosensorMicroneedle |
| spellingShingle | Julia Madden Conor O'Mahony Michael Thompson Alan O'Riordan Paul Galvin Biosensing in dermal interstitial fluid using microneedle based electrochemical devices Sensing and Bio-Sensing Research Dermal interstitial fluid Electrochemical Biosensor Microneedle |
| title | Biosensing in dermal interstitial fluid using microneedle based electrochemical devices |
| title_full | Biosensing in dermal interstitial fluid using microneedle based electrochemical devices |
| title_fullStr | Biosensing in dermal interstitial fluid using microneedle based electrochemical devices |
| title_full_unstemmed | Biosensing in dermal interstitial fluid using microneedle based electrochemical devices |
| title_short | Biosensing in dermal interstitial fluid using microneedle based electrochemical devices |
| title_sort | biosensing in dermal interstitial fluid using microneedle based electrochemical devices |
| topic | Dermal interstitial fluid Electrochemical Biosensor Microneedle |
| url | http://www.sciencedirect.com/science/article/pii/S2214180420300064 |
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