Pyrrolyl and Indolyl α-γ-Diketo Acid Derivatives Acting as Selective Inhibitors of Human Carbonic Anhydrases IX and XII

Pyrrolyl and Indolyl α-γ-Diketo Acid Derivatives Acting as Selective Inhibitors of Human Carbonic Anhydrases IX and XII

Solid tumors are active tissues containing hypoxic regions and producing metabolic acids. By decreasing pH, cancer cells create a hostile environment for surrounding host cells and foster tumor growth and progression. By governing acid/base regulation, carbonic anhydrases (CAs) are involved in sever...

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Bibliographic Details
Main Authors: Davide Ialongo, Antonella Messore, Valentina Noemi Madia, Valeria Tudino, Alessio Nocentini, Paola Gratteri, Simone Giovannuzzi, Claudiu T. Supuran, Alice Nicolai, Susanna Scarpa, Samanta Taurone, Michele Camarda, Marco Artico, Veronica Papa, Francesco Saccoliti, Luigi Scipione, Roberto Di Santo, Roberta Costi
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceuticals
Subjects:
metalloenzyme
carbonic anhydrase
diketo acids
carbonic anhydrase inhibitors
breast cancer
tongue squamous cell carcinoma
Online Access:https://www.mdpi.com/1424-8247/16/2/188

Internet

https://www.mdpi.com/1424-8247/16/2/188

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