Laccase Did It again: A Scalable and Clean Regeneration System for NAD<sup>+</sup> and Its Application in the Synthesis of 12-oxo-Hydroxysteroids

Laccase Did It again: A Scalable and Clean Regeneration System for NAD<sup>+</sup> and Its Application in the Synthesis of 12-oxo-Hydroxysteroids

The specific oxidation of 12α-OH group of hydroxysteroids is required for the preparation of cheno- and ursodeoxycholic acid (CDCA and UDCA, respectively). The C<sub>12</sub> oxidation of hydroxysteroids into their 12-oxo derivatives can selectively be performed by employing 12α-hydroxys...

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Bibliographic Details
Main Authors: Fabio Tonin, Elisabet Martì, Isabel W. C. E. Arends, Ulf Hanefeld
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Catalysts
Subjects:
hydroxysteroid dehydrogenase
laccase-mediator
NAD<sup>+</sup> regeneration
biocatalysis
laccase
Online Access:https://www.mdpi.com/2073-4344/10/6/677

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