Diffusion-Weighted Imaging Prior to Percutaneous Sclerotherapy of Venous Malformations—Proof of Concept Study for Prediction of Clinical Outcome
Prediction of response to percutaneous sclerotherapy in patients with venous malformations (VM) is currently not possible with baseline clinical or imaging characteristics. This prospective single-center study aimed to predict treatment outcome of percutaneous sclerotherapy as measured by quality of...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/12/6/1430 |
| _version_ | 1797488248103108608 |
|---|---|
| author | Mirjam Gerwing Philipp Schindler Kristian Nikolaus Schneider Benedikt Sundermann Michael Köhler Anna-Christina Stamm Vanessa Franziska Schmidt Sybille Perkowski Niklas Deventer Walter L. Heindel Moritz Wildgruber Max Masthoff |
| author_facet | Mirjam Gerwing Philipp Schindler Kristian Nikolaus Schneider Benedikt Sundermann Michael Köhler Anna-Christina Stamm Vanessa Franziska Schmidt Sybille Perkowski Niklas Deventer Walter L. Heindel Moritz Wildgruber Max Masthoff |
| author_sort | Mirjam Gerwing |
| collection | DOAJ |
| description | Prediction of response to percutaneous sclerotherapy in patients with venous malformations (VM) is currently not possible with baseline clinical or imaging characteristics. This prospective single-center study aimed to predict treatment outcome of percutaneous sclerotherapy as measured by quality of life (QoL) by using radiomic analysis of diffusion-weighted (dw) magnetic resonance imaging (MRI) before and after first percutaneous sclerotherapy. In all patients (<i>n</i> = 16) pre-interventional (PRE-) and delta (DELTA-) radiomic features (RF) were extracted from dw-MRI before and after first percutaneous sclerotherapy with ethanol gel or polidocanol foam, while QoL was assessed using the Toronto Extremity Salvage Score (TESS) and the 36-Item Short Form Survey (SF-36) health questionnaire. For selecting features that allow differentiation of clinical response, a stepwise dimension reduction was performed. Logistic regression models were fitted and selected PRE-/DELTA-RF were tested for their predictive value. QoL improved significantly after percutaneous sclerotherapy. While no common baseline patient characteristics were able to predict response to percutaneous sclerotherapy, the radiomics signature of VMs (independent PRE/DELTA-RF) revealed high potential for the prediction of clinical response after percutaneous sclerotherapy. This proof-of-concept study provides first evidence on the potential predictive value of (delta) radiomic analysis from diffusion-weighted MRI for Quality-of-Life outcome after percutaneous sclerotherapy in patients with venous malformations. |
| first_indexed | 2024-03-10T00:00:25Z |
| format | Article |
| id | doaj.art-6f0f30db577749d0b2bf26205a5925ab |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T00:00:25Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6f0f30db577749d0b2bf26205a5925ab2023-11-23T16:18:02ZengMDPI AGDiagnostics2075-44182022-06-01126143010.3390/diagnostics12061430Diffusion-Weighted Imaging Prior to Percutaneous Sclerotherapy of Venous Malformations—Proof of Concept Study for Prediction of Clinical OutcomeMirjam Gerwing0Philipp Schindler1Kristian Nikolaus Schneider2Benedikt Sundermann3Michael Köhler4Anna-Christina Stamm5Vanessa Franziska Schmidt6Sybille Perkowski7Niklas Deventer8Walter L. Heindel9Moritz Wildgruber10Max Masthoff11Clinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, GermanyClinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, GermanyDepartment of Orthopedics and Tumor Orthopedics, University of Muenster and University Hospital of Muenster, 48149 Muenster, GermanyClinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, GermanyClinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, GermanyClinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, GermanyDepartment of Radiology, University Hospital, LMU Munich, 80336 Munich, GermanyClinic for Pediatric and Neonatal Surgery, University of Muenster and University Hospital of Muenster, 48149 Muenster, GermanyDepartment of Orthopedics and Tumor Orthopedics, University of Muenster and University Hospital of Muenster, 48149 Muenster, GermanyClinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, GermanyClinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, GermanyClinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, GermanyPrediction of response to percutaneous sclerotherapy in patients with venous malformations (VM) is currently not possible with baseline clinical or imaging characteristics. This prospective single-center study aimed to predict treatment outcome of percutaneous sclerotherapy as measured by quality of life (QoL) by using radiomic analysis of diffusion-weighted (dw) magnetic resonance imaging (MRI) before and after first percutaneous sclerotherapy. In all patients (<i>n</i> = 16) pre-interventional (PRE-) and delta (DELTA-) radiomic features (RF) were extracted from dw-MRI before and after first percutaneous sclerotherapy with ethanol gel or polidocanol foam, while QoL was assessed using the Toronto Extremity Salvage Score (TESS) and the 36-Item Short Form Survey (SF-36) health questionnaire. For selecting features that allow differentiation of clinical response, a stepwise dimension reduction was performed. Logistic regression models were fitted and selected PRE-/DELTA-RF were tested for their predictive value. QoL improved significantly after percutaneous sclerotherapy. While no common baseline patient characteristics were able to predict response to percutaneous sclerotherapy, the radiomics signature of VMs (independent PRE/DELTA-RF) revealed high potential for the prediction of clinical response after percutaneous sclerotherapy. This proof-of-concept study provides first evidence on the potential predictive value of (delta) radiomic analysis from diffusion-weighted MRI for Quality-of-Life outcome after percutaneous sclerotherapy in patients with venous malformations.https://www.mdpi.com/2075-4418/12/6/1430venous malformationslow-flow vascular malformationsradiomicspercutaneous sclerotherapyquality of life |
| spellingShingle | Mirjam Gerwing Philipp Schindler Kristian Nikolaus Schneider Benedikt Sundermann Michael Köhler Anna-Christina Stamm Vanessa Franziska Schmidt Sybille Perkowski Niklas Deventer Walter L. Heindel Moritz Wildgruber Max Masthoff Diffusion-Weighted Imaging Prior to Percutaneous Sclerotherapy of Venous Malformations—Proof of Concept Study for Prediction of Clinical Outcome Diagnostics venous malformation slow-flow vascular malformations radiomics percutaneous sclerotherapy quality of life |
| title | Diffusion-Weighted Imaging Prior to Percutaneous Sclerotherapy of Venous Malformations—Proof of Concept Study for Prediction of Clinical Outcome |
| title_full | Diffusion-Weighted Imaging Prior to Percutaneous Sclerotherapy of Venous Malformations—Proof of Concept Study for Prediction of Clinical Outcome |
| title_fullStr | Diffusion-Weighted Imaging Prior to Percutaneous Sclerotherapy of Venous Malformations—Proof of Concept Study for Prediction of Clinical Outcome |
| title_full_unstemmed | Diffusion-Weighted Imaging Prior to Percutaneous Sclerotherapy of Venous Malformations—Proof of Concept Study for Prediction of Clinical Outcome |
| title_short | Diffusion-Weighted Imaging Prior to Percutaneous Sclerotherapy of Venous Malformations—Proof of Concept Study for Prediction of Clinical Outcome |
| title_sort | diffusion weighted imaging prior to percutaneous sclerotherapy of venous malformations proof of concept study for prediction of clinical outcome |
| topic | venous malformation slow-flow vascular malformations radiomics percutaneous sclerotherapy quality of life |
| url | https://www.mdpi.com/2075-4418/12/6/1430 |
| work_keys_str_mv | AT mirjamgerwing diffusionweightedimagingpriortopercutaneoussclerotherapyofvenousmalformationsproofofconceptstudyforpredictionofclinicaloutcome AT philippschindler diffusionweightedimagingpriortopercutaneoussclerotherapyofvenousmalformationsproofofconceptstudyforpredictionofclinicaloutcome AT kristiannikolausschneider diffusionweightedimagingpriortopercutaneoussclerotherapyofvenousmalformationsproofofconceptstudyforpredictionofclinicaloutcome AT benediktsundermann diffusionweightedimagingpriortopercutaneoussclerotherapyofvenousmalformationsproofofconceptstudyforpredictionofclinicaloutcome AT michaelkohler diffusionweightedimagingpriortopercutaneoussclerotherapyofvenousmalformationsproofofconceptstudyforpredictionofclinicaloutcome AT annachristinastamm diffusionweightedimagingpriortopercutaneoussclerotherapyofvenousmalformationsproofofconceptstudyforpredictionofclinicaloutcome AT vanessafranziskaschmidt diffusionweightedimagingpriortopercutaneoussclerotherapyofvenousmalformationsproofofconceptstudyforpredictionofclinicaloutcome AT sybilleperkowski diffusionweightedimagingpriortopercutaneoussclerotherapyofvenousmalformationsproofofconceptstudyforpredictionofclinicaloutcome AT niklasdeventer diffusionweightedimagingpriortopercutaneoussclerotherapyofvenousmalformationsproofofconceptstudyforpredictionofclinicaloutcome AT walterlheindel diffusionweightedimagingpriortopercutaneoussclerotherapyofvenousmalformationsproofofconceptstudyforpredictionofclinicaloutcome AT moritzwildgruber diffusionweightedimagingpriortopercutaneoussclerotherapyofvenousmalformationsproofofconceptstudyforpredictionofclinicaloutcome AT maxmasthoff diffusionweightedimagingpriortopercutaneoussclerotherapyofvenousmalformationsproofofconceptstudyforpredictionofclinicaloutcome |