The Gut Microbiota in Immune-Mediated Inflammatory Diseases
The collection of microbes and their genes that exist within and on the human body, collectively known as the microbiome has emerged as a principal factor in human health and disease. Humans and microbes have established a symbiotic association over time, and perturbations in this association have b...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-07-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01081/full |
| _version_ | 1830339739582988288 |
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| author | Jessica D Forbes Jessica D Forbes Gary Van Domselaar Gary Van Domselaar Charles Noah Bernstein |
| author_facet | Jessica D Forbes Jessica D Forbes Gary Van Domselaar Gary Van Domselaar Charles Noah Bernstein |
| author_sort | Jessica D Forbes |
| collection | DOAJ |
| description | The collection of microbes and their genes that exist within and on the human body, collectively known as the microbiome has emerged as a principal factor in human health and disease. Humans and microbes have established a symbiotic association over time, and perturbations in this association have been linked to several immune-mediated inflammatory diseases (IMID) including inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis. IMID is a term used to describe a group of chronic, highly disabling diseases that affect different organ systems. Though a cornerstone commonality between IMID is the idiopathic nature of disease, a considerable portion of their pathobiology overlaps including epidemiological co-occurrence, genetic susceptibility loci and environmental risk factors. At present, it is clear that persons with an IMID are at an increased risk for developing comorbidities, including additional IMID. Advancements in sequencing technologies and a parallel explosion of 16S rDNA and metagenomics community profiling studies have allowed for the characterization of microbiomes throughout the human body including the gut, in a myriad of human diseases and in health. The main challenge now is to determine if alterations of gut flora are common between IMID or, if particular changes in the gut community are in fact specific to a single disease. Herein, we review and discuss the relationships between the gut microbiota and IMIDKeywords: gut microbiome, systems microbiology gut metagenome, chronic immune mediated inflammatory diseases |
| first_indexed | 2024-12-19T21:02:47Z |
| format | Article |
| id | doaj.art-6f1091590e9142a3916c7e9754f52b0e |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-19T21:02:47Z |
| publishDate | 2016-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-6f1091590e9142a3916c7e9754f52b0e2022-12-21T20:05:46ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2016-07-01710.3389/fmicb.2016.01081208415The Gut Microbiota in Immune-Mediated Inflammatory DiseasesJessica D Forbes0Jessica D Forbes1Gary Van Domselaar2Gary Van Domselaar3Charles Noah Bernstein4University of ManitobaNational Microbiology Laboratory, Public Health Agency of CanadaUniversity of ManitobaNational Microbiology Laboratory, Public Health Agency of CanadaUniversity of ManitobaThe collection of microbes and their genes that exist within and on the human body, collectively known as the microbiome has emerged as a principal factor in human health and disease. Humans and microbes have established a symbiotic association over time, and perturbations in this association have been linked to several immune-mediated inflammatory diseases (IMID) including inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis. IMID is a term used to describe a group of chronic, highly disabling diseases that affect different organ systems. Though a cornerstone commonality between IMID is the idiopathic nature of disease, a considerable portion of their pathobiology overlaps including epidemiological co-occurrence, genetic susceptibility loci and environmental risk factors. At present, it is clear that persons with an IMID are at an increased risk for developing comorbidities, including additional IMID. Advancements in sequencing technologies and a parallel explosion of 16S rDNA and metagenomics community profiling studies have allowed for the characterization of microbiomes throughout the human body including the gut, in a myriad of human diseases and in health. The main challenge now is to determine if alterations of gut flora are common between IMID or, if particular changes in the gut community are in fact specific to a single disease. Herein, we review and discuss the relationships between the gut microbiota and IMIDKeywords: gut microbiome, systems microbiology gut metagenome, chronic immune mediated inflammatory diseaseshttp://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01081/fullMetagenomemicrobiomesystems microbiologyDysbiosischronic immune mediated inflammatory diseases |
| spellingShingle | Jessica D Forbes Jessica D Forbes Gary Van Domselaar Gary Van Domselaar Charles Noah Bernstein The Gut Microbiota in Immune-Mediated Inflammatory Diseases Frontiers in Microbiology Metagenome microbiome systems microbiology Dysbiosis chronic immune mediated inflammatory diseases |
| title | The Gut Microbiota in Immune-Mediated Inflammatory Diseases |
| title_full | The Gut Microbiota in Immune-Mediated Inflammatory Diseases |
| title_fullStr | The Gut Microbiota in Immune-Mediated Inflammatory Diseases |
| title_full_unstemmed | The Gut Microbiota in Immune-Mediated Inflammatory Diseases |
| title_short | The Gut Microbiota in Immune-Mediated Inflammatory Diseases |
| title_sort | gut microbiota in immune mediated inflammatory diseases |
| topic | Metagenome microbiome systems microbiology Dysbiosis chronic immune mediated inflammatory diseases |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01081/full |
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