Interaction between warfarin and molnupiravir in a patient with coronavirus disease 2019 infection
Molnupiravir is a novel antiviral agent for coronavirus disease 2019 (COVID-19) treatment. Warfarin is an oral anticoagulation agent with difficult management due to drug interactions. Here, we describe a case of international normalized ratio (INR) prolongation in a patient who administrated warfar...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=11;spage=7463;epage=7465;aulast=Mizutani |
| _version_ | 1797954864803741696 |
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| author | Hikari Mizutani Tetsuro Koide Takashi Omura Kumiko Ito |
| author_facet | Hikari Mizutani Tetsuro Koide Takashi Omura Kumiko Ito |
| author_sort | Hikari Mizutani |
| collection | DOAJ |
| description | Molnupiravir is a novel antiviral agent for coronavirus disease 2019 (COVID-19) treatment. Warfarin is an oral anticoagulation agent with difficult management due to drug interactions. Here, we describe a case of international normalized ratio (INR) prolongation in a patient who administrated warfarin with molnupiravir for COVID-19. An increased INR at 3.80, enough to discontinue warfarin, was observed on the fifth day of molnupiravir therapy, although the warfarin dose and INR were stable at 4 mg/day and approximately 2.0 before the molnupiravir initiation, respectively. Factors that affect the INR, such as severe COVID-19, cytokine, diet, liver dysfunction, and the concomitant use of medications other than molnupiravir, were unlikely in this patient. This case suggests that healthcare physicians should be aware of the possibility of drug interaction between molnupiravir and warfarin. |
| first_indexed | 2024-04-10T23:24:09Z |
| format | Article |
| id | doaj.art-6f10a507496746eb908077eaa892b288 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-04-10T23:24:09Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-6f10a507496746eb908077eaa892b2882023-01-12T12:42:33ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632022-01-0111117463746510.4103/jfmpc.jfmpc_1387_22Interaction between warfarin and molnupiravir in a patient with coronavirus disease 2019 infectionHikari MizutaniTetsuro KoideTakashi OmuraKumiko ItoMolnupiravir is a novel antiviral agent for coronavirus disease 2019 (COVID-19) treatment. Warfarin is an oral anticoagulation agent with difficult management due to drug interactions. Here, we describe a case of international normalized ratio (INR) prolongation in a patient who administrated warfarin with molnupiravir for COVID-19. An increased INR at 3.80, enough to discontinue warfarin, was observed on the fifth day of molnupiravir therapy, although the warfarin dose and INR were stable at 4 mg/day and approximately 2.0 before the molnupiravir initiation, respectively. Factors that affect the INR, such as severe COVID-19, cytokine, diet, liver dysfunction, and the concomitant use of medications other than molnupiravir, were unlikely in this patient. This case suggests that healthcare physicians should be aware of the possibility of drug interaction between molnupiravir and warfarin.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=11;spage=7463;epage=7465;aulast=Mizutanicoronavirus disease 2019drug interactionmolnupiravirwarfarin |
| spellingShingle | Hikari Mizutani Tetsuro Koide Takashi Omura Kumiko Ito Interaction between warfarin and molnupiravir in a patient with coronavirus disease 2019 infection Journal of Family Medicine and Primary Care coronavirus disease 2019 drug interaction molnupiravir warfarin |
| title | Interaction between warfarin and molnupiravir in a patient with coronavirus disease 2019 infection |
| title_full | Interaction between warfarin and molnupiravir in a patient with coronavirus disease 2019 infection |
| title_fullStr | Interaction between warfarin and molnupiravir in a patient with coronavirus disease 2019 infection |
| title_full_unstemmed | Interaction between warfarin and molnupiravir in a patient with coronavirus disease 2019 infection |
| title_short | Interaction between warfarin and molnupiravir in a patient with coronavirus disease 2019 infection |
| title_sort | interaction between warfarin and molnupiravir in a patient with coronavirus disease 2019 infection |
| topic | coronavirus disease 2019 drug interaction molnupiravir warfarin |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=11;spage=7463;epage=7465;aulast=Mizutani |
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