Role and regulation of Abelson tyrosine kinase in Crk-associated substrate/profilin-1 interaction and airway smooth muscle contraction

Role and regulation of Abelson tyrosine kinase in Crk-associated substrate/profilin-1 interaction and airway smooth muscle contraction

Abstract Background Airway smooth muscle contraction is critical for maintenance of appropriate airway tone, and has been implicated in asthma pathogenesis. Smooth muscle contraction requires an “engine” (myosin activation) and a “transmission system” (actin cytoskeletal remodeling). However, the me...

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Bibliographic Details
Main Authors: Yinna Wang, Alyssa C. Rezey, Ruping Wang, Dale D. Tang
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Respiratory Research
Subjects:
c-Abl kinase
Crk-associated substrate
Profilin-1
Smooth muscle
Excitation-contraction coupling
Actin cytoskeleton
Online Access:http://link.springer.com/article/10.1186/s12931-017-0709-4

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