Longitudinal surveillance of serum titanium ion levels in patients with indigenous 3D printed total temporomandibular joint replacement
Abstract The purpose of this longitudinal study was to surveil the serum titanium ion levels at various time intervals in patients with indigenous 3D-printed total temporomandibular joint replacement (TMJ TJR). The study was conducted on 11 patients (male: 8; female: 3) who had undergone unilateral...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-05-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-33229-5 |
| _version_ | 1797832092815458304 |
|---|---|
| author | Garima Khandelwal Ajoy Roychoudhury Ongkila Bhutia A. Shariff |
| author_facet | Garima Khandelwal Ajoy Roychoudhury Ongkila Bhutia A. Shariff |
| author_sort | Garima Khandelwal |
| collection | DOAJ |
| description | Abstract The purpose of this longitudinal study was to surveil the serum titanium ion levels at various time intervals in patients with indigenous 3D-printed total temporomandibular joint replacement (TMJ TJR). The study was conducted on 11 patients (male: 8; female: 3) who had undergone unilateral or bilateral TMJ TJR. Blood samples were drawn preoperatively (T0), 3 months (T1), 6 months (T2), and 1 year (T3) postoperatively. Data were analyzed and a p value of < 0.05 was considered statistically significant. The mean serum titanium ion levels at T0, T1, T2, and T3 was 9.34 ± 8.70 µg/L (mcg/L), 35.97 ± 20.27 mcg/L, 31.68 ± 17.03 mcg/L, and 47.91 ± 15.47 mcg/L respectively. The mean serum titanium ion levels increased significantly at T1 (p = 0.009), T2 (p = 0.032), and T3 (p = 0.00) interval. There was no significant difference between unilateral and bilateral groups. Serum titanium ion continued to show increased levels till the last follow-up of 1 year. These initial serum titanium ion levels increase is due to the initial wear phase of the prosthesis which manifests over 1 year. Further studies with large sample sizes and long-term follow-ups are required to see the deleterious effect if any on the TMJ TJR. |
| first_indexed | 2024-04-09T14:02:13Z |
| format | Article |
| id | doaj.art-6f135bdd6e774b8485043f7f0b3e4fd9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T14:02:13Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6f135bdd6e774b8485043f7f0b3e4fd92023-05-07T11:13:19ZengNature PortfolioScientific Reports2045-23222023-05-011311810.1038/s41598-023-33229-5Longitudinal surveillance of serum titanium ion levels in patients with indigenous 3D printed total temporomandibular joint replacementGarima Khandelwal0Ajoy Roychoudhury1Ongkila Bhutia2A. Shariff3Department of Oral and Maxillofacial Surgery, All India Institute of Medical SciencesDepartment of Oral and Maxillofacial Surgery, All India Institute of Medical SciencesDepartment of Oral and Maxillofacial Surgery, All India Institute of Medical SciencesDepartment of Anatomy, All India Institute of Medical SciencesAbstract The purpose of this longitudinal study was to surveil the serum titanium ion levels at various time intervals in patients with indigenous 3D-printed total temporomandibular joint replacement (TMJ TJR). The study was conducted on 11 patients (male: 8; female: 3) who had undergone unilateral or bilateral TMJ TJR. Blood samples were drawn preoperatively (T0), 3 months (T1), 6 months (T2), and 1 year (T3) postoperatively. Data were analyzed and a p value of < 0.05 was considered statistically significant. The mean serum titanium ion levels at T0, T1, T2, and T3 was 9.34 ± 8.70 µg/L (mcg/L), 35.97 ± 20.27 mcg/L, 31.68 ± 17.03 mcg/L, and 47.91 ± 15.47 mcg/L respectively. The mean serum titanium ion levels increased significantly at T1 (p = 0.009), T2 (p = 0.032), and T3 (p = 0.00) interval. There was no significant difference between unilateral and bilateral groups. Serum titanium ion continued to show increased levels till the last follow-up of 1 year. These initial serum titanium ion levels increase is due to the initial wear phase of the prosthesis which manifests over 1 year. Further studies with large sample sizes and long-term follow-ups are required to see the deleterious effect if any on the TMJ TJR.https://doi.org/10.1038/s41598-023-33229-5 |
| spellingShingle | Garima Khandelwal Ajoy Roychoudhury Ongkila Bhutia A. Shariff Longitudinal surveillance of serum titanium ion levels in patients with indigenous 3D printed total temporomandibular joint replacement Scientific Reports |
| title | Longitudinal surveillance of serum titanium ion levels in patients with indigenous 3D printed total temporomandibular joint replacement |
| title_full | Longitudinal surveillance of serum titanium ion levels in patients with indigenous 3D printed total temporomandibular joint replacement |
| title_fullStr | Longitudinal surveillance of serum titanium ion levels in patients with indigenous 3D printed total temporomandibular joint replacement |
| title_full_unstemmed | Longitudinal surveillance of serum titanium ion levels in patients with indigenous 3D printed total temporomandibular joint replacement |
| title_short | Longitudinal surveillance of serum titanium ion levels in patients with indigenous 3D printed total temporomandibular joint replacement |
| title_sort | longitudinal surveillance of serum titanium ion levels in patients with indigenous 3d printed total temporomandibular joint replacement |
| url | https://doi.org/10.1038/s41598-023-33229-5 |
| work_keys_str_mv | AT garimakhandelwal longitudinalsurveillanceofserumtitaniumionlevelsinpatientswithindigenous3dprintedtotaltemporomandibularjointreplacement AT ajoyroychoudhury longitudinalsurveillanceofserumtitaniumionlevelsinpatientswithindigenous3dprintedtotaltemporomandibularjointreplacement AT ongkilabhutia longitudinalsurveillanceofserumtitaniumionlevelsinpatientswithindigenous3dprintedtotaltemporomandibularjointreplacement AT ashariff longitudinalsurveillanceofserumtitaniumionlevelsinpatientswithindigenous3dprintedtotaltemporomandibularjointreplacement |