Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine: A Comprehensive Review
Mesenchymal Stem Cells are potent therapeutic candidates in the field of regenerative medicine, owing to their immunomodulatory and differentiation potential. However, several complications come with their translational application like viability, duration, and degree of expansion, long-term storage...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/11/8/784 |
| _version_ | 1797523202364145664 |
|---|---|
| author | Biswajit Panda Yashvi Sharma Suchi Gupta Sujata Mohanty |
| author_facet | Biswajit Panda Yashvi Sharma Suchi Gupta Sujata Mohanty |
| author_sort | Biswajit Panda |
| collection | DOAJ |
| description | Mesenchymal Stem Cells are potent therapeutic candidates in the field of regenerative medicine, owing to their immunomodulatory and differentiation potential. However, several complications come with their translational application like viability, duration, and degree of expansion, long-term storage, and high maintenance cost. Therefore, drawbacks of cell-based therapy can be overcome by a novel therapeutic modality emerging in translational research and application, i.e., exosomes. These small vesicles derived from mesenchymal stem cells are emerging as new avenues in the field of nano-medicine. These nano-vesicles have caught the attention of researchers with their potency as regenerative medicine both in nanotherapeutics and drug delivery systems. In this review, we discuss the current knowledge in the biology and handling of exosomes, with their limitations and future applications. Additionally, we highlight current perspectives that primarily focus on their effect on various diseases and their potential as a drug delivery vehicle. |
| first_indexed | 2024-03-10T08:40:02Z |
| format | Article |
| id | doaj.art-6f13763268214be3946daa944ac90968 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T08:40:02Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-6f13763268214be3946daa944ac909682023-11-22T08:22:51ZengMDPI AGLife2075-17292021-08-0111878410.3390/life11080784Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine: A Comprehensive ReviewBiswajit Panda0Yashvi Sharma1Suchi Gupta2Sujata Mohanty3DBT-Centre of Excellence for Stem Cell Research, Stem Cell Facility, All India Institute of Medical Sciences, New Delhi 110029, IndiaDBT-Centre of Excellence for Stem Cell Research, Stem Cell Facility, All India Institute of Medical Sciences, New Delhi 110029, IndiaDBT-Centre of Excellence for Stem Cell Research, Stem Cell Facility, All India Institute of Medical Sciences, New Delhi 110029, IndiaDBT-Centre of Excellence for Stem Cell Research, Stem Cell Facility, All India Institute of Medical Sciences, New Delhi 110029, IndiaMesenchymal Stem Cells are potent therapeutic candidates in the field of regenerative medicine, owing to their immunomodulatory and differentiation potential. However, several complications come with their translational application like viability, duration, and degree of expansion, long-term storage, and high maintenance cost. Therefore, drawbacks of cell-based therapy can be overcome by a novel therapeutic modality emerging in translational research and application, i.e., exosomes. These small vesicles derived from mesenchymal stem cells are emerging as new avenues in the field of nano-medicine. These nano-vesicles have caught the attention of researchers with their potency as regenerative medicine both in nanotherapeutics and drug delivery systems. In this review, we discuss the current knowledge in the biology and handling of exosomes, with their limitations and future applications. Additionally, we highlight current perspectives that primarily focus on their effect on various diseases and their potential as a drug delivery vehicle.https://www.mdpi.com/2075-1729/11/8/784exosomesmesenchymal stem cellsdrug delivery systemtherapeuticsnano-medicineimmunomodulation |
| spellingShingle | Biswajit Panda Yashvi Sharma Suchi Gupta Sujata Mohanty Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine: A Comprehensive Review Life exosomes mesenchymal stem cells drug delivery system therapeutics nano-medicine immunomodulation |
| title | Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine: A Comprehensive Review |
| title_full | Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine: A Comprehensive Review |
| title_fullStr | Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine: A Comprehensive Review |
| title_full_unstemmed | Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine: A Comprehensive Review |
| title_short | Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine: A Comprehensive Review |
| title_sort | mesenchymal stem cell derived exosomes as an emerging paradigm for regenerative therapy and nano medicine a comprehensive review |
| topic | exosomes mesenchymal stem cells drug delivery system therapeutics nano-medicine immunomodulation |
| url | https://www.mdpi.com/2075-1729/11/8/784 |
| work_keys_str_mv | AT biswajitpanda mesenchymalstemcellderivedexosomesasanemergingparadigmforregenerativetherapyandnanomedicineacomprehensivereview AT yashvisharma mesenchymalstemcellderivedexosomesasanemergingparadigmforregenerativetherapyandnanomedicineacomprehensivereview AT suchigupta mesenchymalstemcellderivedexosomesasanemergingparadigmforregenerativetherapyandnanomedicineacomprehensivereview AT sujatamohanty mesenchymalstemcellderivedexosomesasanemergingparadigmforregenerativetherapyandnanomedicineacomprehensivereview |