The abundance of bifidobacterium in relation to visceral obesity and serum uric acid
Abstract Gut microbiome has been shown to play a role in the development of obesity in recent studies. Most of these studies on obesity were based on the BMI classification criteria, which doesn't distinguish Visceral adipose tissue (VAT) from subcutaneous adipose tissue (SAT). Some studies sho...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-17417-3 |
| _version_ | 1818502852475092992 |
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| author | Hualan Gong Hainv Gao Qingye Ren Jia He |
| author_facet | Hualan Gong Hainv Gao Qingye Ren Jia He |
| author_sort | Hualan Gong |
| collection | DOAJ |
| description | Abstract Gut microbiome has been shown to play a role in the development of obesity in recent studies. Most of these studies on obesity were based on the BMI classification criteria, which doesn't distinguish Visceral adipose tissue (VAT) from subcutaneous adipose tissue (SAT). Some studies showed that VAT has a higher risk of inducing metabolic diseases than SAT. This study focused on the visceral obesity defined by increased visceral fat area. The present study was designed to investigate the association of visceral obesity with gut predominant microbiota and metabolic status. This study included 372 healthy individuals from medical examination center in Shulan Hangzhou Hospital. Quantitative polymerase chain reaction (q-PCR) technique was used to detect ten kinds of gut predominant bacteria in fresh feces. Visceral fat area (VFA) was measured by the bioimpedance analyzer (INBODY720, Korea). The abundance of Bifidobacterium significantly decreased in the visceral obesity group. Compared with the lean group, Visceral obesity group had significantly higher levels of LDL, TG, FBG, serum uric acid (SUA) and lower levels of HDL. SUA was an independent impact factor for Bifidobacterium. SUA was negatively correlated with Bifidobacterium and positively correlated with VFA. In the mediation analysis, SUA showed significant mediation effect. SUA may be a mediating factor between decreased Bifidobacterium and increased VAT. |
| first_indexed | 2024-12-10T21:15:57Z |
| format | Article |
| id | doaj.art-6f14492d2e57444cb754a9d137ac870e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-10T21:15:57Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6f14492d2e57444cb754a9d137ac870e2022-12-22T01:33:19ZengNature PortfolioScientific Reports2045-23222022-07-011211710.1038/s41598-022-17417-3The abundance of bifidobacterium in relation to visceral obesity and serum uric acidHualan Gong0Hainv Gao1Qingye Ren2Jia He3Shulan (Hangzhou) Hospital Affiliated to Zhejiang, Shuren University Shulan International Medical CollegeShulan (Hangzhou) Hospital Affiliated to Zhejiang, Shuren University Shulan International Medical CollegeShulan (Hangzhou) Hospital Affiliated to Zhejiang, Shuren University Shulan International Medical CollegeShulan (Hangzhou) Hospital Affiliated to Zhejiang, Shuren University Shulan International Medical CollegeAbstract Gut microbiome has been shown to play a role in the development of obesity in recent studies. Most of these studies on obesity were based on the BMI classification criteria, which doesn't distinguish Visceral adipose tissue (VAT) from subcutaneous adipose tissue (SAT). Some studies showed that VAT has a higher risk of inducing metabolic diseases than SAT. This study focused on the visceral obesity defined by increased visceral fat area. The present study was designed to investigate the association of visceral obesity with gut predominant microbiota and metabolic status. This study included 372 healthy individuals from medical examination center in Shulan Hangzhou Hospital. Quantitative polymerase chain reaction (q-PCR) technique was used to detect ten kinds of gut predominant bacteria in fresh feces. Visceral fat area (VFA) was measured by the bioimpedance analyzer (INBODY720, Korea). The abundance of Bifidobacterium significantly decreased in the visceral obesity group. Compared with the lean group, Visceral obesity group had significantly higher levels of LDL, TG, FBG, serum uric acid (SUA) and lower levels of HDL. SUA was an independent impact factor for Bifidobacterium. SUA was negatively correlated with Bifidobacterium and positively correlated with VFA. In the mediation analysis, SUA showed significant mediation effect. SUA may be a mediating factor between decreased Bifidobacterium and increased VAT.https://doi.org/10.1038/s41598-022-17417-3 |
| spellingShingle | Hualan Gong Hainv Gao Qingye Ren Jia He The abundance of bifidobacterium in relation to visceral obesity and serum uric acid Scientific Reports |
| title | The abundance of bifidobacterium in relation to visceral obesity and serum uric acid |
| title_full | The abundance of bifidobacterium in relation to visceral obesity and serum uric acid |
| title_fullStr | The abundance of bifidobacterium in relation to visceral obesity and serum uric acid |
| title_full_unstemmed | The abundance of bifidobacterium in relation to visceral obesity and serum uric acid |
| title_short | The abundance of bifidobacterium in relation to visceral obesity and serum uric acid |
| title_sort | abundance of bifidobacterium in relation to visceral obesity and serum uric acid |
| url | https://doi.org/10.1038/s41598-022-17417-3 |
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