Unsatisfactory glycemic control in type 2 Diabetes mellitus patients: predictive factors and negative clinical outcomes with the use of antidiabetic drugs
ABSTRACT Many factors can interfere with glycemic control in patients with type 2 diabetes mellitus and this patient group has an increased risk of experiencing drug-related negative outcomes (DNO). The aim of this study was to identify the predictive factors of unsatisfactory glycemic control and D...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400801&lng=en&tlng=en |
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| author | Maria Aparecida Marczynski Karine Laura Cortellazzi Sílvio Barberato-Filho Rogério Heládio Lopes Motta Alexandre Eduardo Franzin Vieira Maria Teresa Verrone Quilici Cristiane de Cássia Bergamaschi |
| author_facet | Maria Aparecida Marczynski Karine Laura Cortellazzi Sílvio Barberato-Filho Rogério Heládio Lopes Motta Alexandre Eduardo Franzin Vieira Maria Teresa Verrone Quilici Cristiane de Cássia Bergamaschi |
| author_sort | Maria Aparecida Marczynski |
| collection | DOAJ |
| description | ABSTRACT Many factors can interfere with glycemic control in patients with type 2 diabetes mellitus and this patient group has an increased risk of experiencing drug-related negative outcomes (DNO). The aim of this study was to identify the predictive factors of unsatisfactory glycemic control and DNO in this group of patients. A cross-sectional study was conducted collecting data from prescriptions and interviews with 100 patients of the Endocrinology Clinic of the Hospital Complex of Sorocaba, São Paulo, Brazil. Variables associated with unsatisfactory glycemic control were determined and the DNO associated with antidiabetic drugs identified. Age (<65 years) (OR=4.09), family history of diabetes (OR=3.24), use of combined therapy to treat diabetes (2-4 antidiabetic drugs) (OR=5.13) and presence of DNO (OR=5.92) were found to be predictive factors for poor patient glycemic control. DNO were observed in 49% of the patients and were caused predominantly by ineffectiveness in patients with poor glycemic control (p<0.05). There was no significant difference between groups (satisfactory and unsatisfactory glycemic control) for DNO caused by safety issues (p>0.05). Characterization of the profile of patients with uncontrolled diabetes and of aspects associated with drug treatment can contribute to the planning of interventions to improve patient care. |
| first_indexed | 2024-12-13T22:51:09Z |
| format | Article |
| id | doaj.art-6f174dec2b1b4f73bfd34a8df1906ffd |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-13T22:51:09Z |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-6f174dec2b1b4f73bfd34a8df1906ffd2022-12-21T23:28:36ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-979052480181210.1590/s1984-82502016000400026S1984-82502016000400801Unsatisfactory glycemic control in type 2 Diabetes mellitus patients: predictive factors and negative clinical outcomes with the use of antidiabetic drugsMaria Aparecida MarczynskiKarine Laura CortellazziSílvio Barberato-FilhoRogério Heládio Lopes MottaAlexandre Eduardo Franzin VieiraMaria Teresa Verrone QuiliciCristiane de Cássia BergamaschiABSTRACT Many factors can interfere with glycemic control in patients with type 2 diabetes mellitus and this patient group has an increased risk of experiencing drug-related negative outcomes (DNO). The aim of this study was to identify the predictive factors of unsatisfactory glycemic control and DNO in this group of patients. A cross-sectional study was conducted collecting data from prescriptions and interviews with 100 patients of the Endocrinology Clinic of the Hospital Complex of Sorocaba, São Paulo, Brazil. Variables associated with unsatisfactory glycemic control were determined and the DNO associated with antidiabetic drugs identified. Age (<65 years) (OR=4.09), family history of diabetes (OR=3.24), use of combined therapy to treat diabetes (2-4 antidiabetic drugs) (OR=5.13) and presence of DNO (OR=5.92) were found to be predictive factors for poor patient glycemic control. DNO were observed in 49% of the patients and were caused predominantly by ineffectiveness in patients with poor glycemic control (p<0.05). There was no significant difference between groups (satisfactory and unsatisfactory glycemic control) for DNO caused by safety issues (p>0.05). Characterization of the profile of patients with uncontrolled diabetes and of aspects associated with drug treatment can contribute to the planning of interventions to improve patient care.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400801&lng=en&tlng=enType 2 Diabetes mellitusType 2 Diabetes mellitus/study/drugs usePharmaceutical careDrug-related negative outcomes. |
| spellingShingle | Maria Aparecida Marczynski Karine Laura Cortellazzi Sílvio Barberato-Filho Rogério Heládio Lopes Motta Alexandre Eduardo Franzin Vieira Maria Teresa Verrone Quilici Cristiane de Cássia Bergamaschi Unsatisfactory glycemic control in type 2 Diabetes mellitus patients: predictive factors and negative clinical outcomes with the use of antidiabetic drugs Brazilian Journal of Pharmaceutical Sciences Type 2 Diabetes mellitus Type 2 Diabetes mellitus/study/drugs use Pharmaceutical care Drug-related negative outcomes. |
| title | Unsatisfactory glycemic control in type 2 Diabetes mellitus patients: predictive factors and negative clinical outcomes with the use of antidiabetic drugs |
| title_full | Unsatisfactory glycemic control in type 2 Diabetes mellitus patients: predictive factors and negative clinical outcomes with the use of antidiabetic drugs |
| title_fullStr | Unsatisfactory glycemic control in type 2 Diabetes mellitus patients: predictive factors and negative clinical outcomes with the use of antidiabetic drugs |
| title_full_unstemmed | Unsatisfactory glycemic control in type 2 Diabetes mellitus patients: predictive factors and negative clinical outcomes with the use of antidiabetic drugs |
| title_short | Unsatisfactory glycemic control in type 2 Diabetes mellitus patients: predictive factors and negative clinical outcomes with the use of antidiabetic drugs |
| title_sort | unsatisfactory glycemic control in type 2 diabetes mellitus patients predictive factors and negative clinical outcomes with the use of antidiabetic drugs |
| topic | Type 2 Diabetes mellitus Type 2 Diabetes mellitus/study/drugs use Pharmaceutical care Drug-related negative outcomes. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400801&lng=en&tlng=en |
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