Irbesartan-mediated AT receptor blockade attenuates hyposmotic-induced enhancement of current and prevents shortening of action potential duration in atrial myocytes

Irbesartan-mediated AT receptor blockade attenuates hyposmotic-induced enhancement of current and prevents shortening of action potential duration in atrial myocytes

Introduction: Stretch of the atrial membrane upregulates the slow component of delayed rectifier K + current ( I Ks ). Blockade of angiotensin II subtype 1 receptors (AT 1 R) attenuates this increase in I Ks . The present study aimed to examine the effects of irbesartan, a selective AT 1 R blocker (...

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Bibliographic Details
Main Authors: Jie Wu, Wei-Guang Ding, Jin Zhao, Wei-Jin Zang, Hiroshi Matsuura, Minoru Horie
Format: Article
Language:English
Published: SAGE Publications 2014-12-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.1177/1470320312474855

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