A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission
Mosquito saliva can affect transmission of Plasmodium to mammalian hosts, but active saliva components or mechanisms are poorly understood. Here, the authors identify a mosquito saliva protein that binds Plasmodium sporozoites and inhibits cell traversal in vitro and sporozoite speed in mice.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05374-3 |
| _version_ | 1818841466795982848 |
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| author | Tyler R. Schleicher Jing Yang Marianna Freudzon Alison Rembisz Samuel Craft Madeleine Hamilton Morven Graham Godfree Mlambo Abhai K. Tripathi Yue Li Peter Cresswell Photini Sinnis George Dimopoulos Erol Fikrig |
| author_facet | Tyler R. Schleicher Jing Yang Marianna Freudzon Alison Rembisz Samuel Craft Madeleine Hamilton Morven Graham Godfree Mlambo Abhai K. Tripathi Yue Li Peter Cresswell Photini Sinnis George Dimopoulos Erol Fikrig |
| author_sort | Tyler R. Schleicher |
| collection | DOAJ |
| description | Mosquito saliva can affect transmission of Plasmodium to mammalian hosts, but active saliva components or mechanisms are poorly understood. Here, the authors identify a mosquito saliva protein that binds Plasmodium sporozoites and inhibits cell traversal in vitro and sporozoite speed in mice. |
| first_indexed | 2024-12-19T04:26:32Z |
| format | Article |
| id | doaj.art-6f1de94305704e90b23021c6aaa9d413 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:26:32Z |
| publishDate | 2018-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6f1de94305704e90b23021c6aaa9d4132022-12-21T20:35:59ZengNature PortfolioNature Communications2041-17232018-07-019111210.1038/s41467-018-05374-3A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmissionTyler R. Schleicher0Jing Yang1Marianna Freudzon2Alison Rembisz3Samuel Craft4Madeleine Hamilton5Morven Graham6Godfree Mlambo7Abhai K. Tripathi8Yue Li9Peter Cresswell10Photini Sinnis11George Dimopoulos12Erol Fikrig13Section of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineSection of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineDepartment of Dermatology, Yale University School of MedicineSection of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineSection of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineSection of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineYale Center for Cellular and Molecular Imaging, Yale University School of MedicineDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins UniversityDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins UniversityDepartment of Immunobiology, Yale University School of MedicineDepartment of Immunobiology, Yale University School of MedicineDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins UniversityDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins UniversitySection of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineMosquito saliva can affect transmission of Plasmodium to mammalian hosts, but active saliva components or mechanisms are poorly understood. Here, the authors identify a mosquito saliva protein that binds Plasmodium sporozoites and inhibits cell traversal in vitro and sporozoite speed in mice.https://doi.org/10.1038/s41467-018-05374-3 |
| spellingShingle | Tyler R. Schleicher Jing Yang Marianna Freudzon Alison Rembisz Samuel Craft Madeleine Hamilton Morven Graham Godfree Mlambo Abhai K. Tripathi Yue Li Peter Cresswell Photini Sinnis George Dimopoulos Erol Fikrig A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission Nature Communications |
| title | A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission |
| title_full | A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission |
| title_fullStr | A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission |
| title_full_unstemmed | A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission |
| title_short | A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission |
| title_sort | mosquito salivary gland protein partially inhibits plasmodium sporozoite cell traversal and transmission |
| url | https://doi.org/10.1038/s41467-018-05374-3 |
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