Modelling of Escherichia coli Cultivations: Acetate Inhibition in a Fed-batch Culture
A set of three competing, unstructured models has been proposed to model biomass growth, glucose utilization, acetate formation, dissolved oxygen consumption and carbon dioxide accumulation of a fed-batch cultivation process of Escherichia coli. The inhibiting effect of acetate on growth of E. coli...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Academic Publishing House
2006-04-01
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| Series: | Bioautomation |
| Subjects: | |
| Online Access: | http://www.clbme.bas.bg/bioautomation/2006/vol_4.1/files/4_1.1.pdf |
| _version_ | 1828235513016877056 |
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| author | Stoyan Tzonkov Olympia Roeva |
| author_facet | Stoyan Tzonkov Olympia Roeva |
| author_sort | Stoyan Tzonkov |
| collection | DOAJ |
| description | A set of three competing, unstructured models has been proposed to model biomass growth, glucose utilization, acetate formation, dissolved oxygen consumption and carbon dioxide accumulation of a fed-batch cultivation process of Escherichia coli. The inhibiting effect of acetate on growth of E. coli cultures is included in the considered models. The model identification is carried out using experimental data from the cultivation process. Genetic algorithms are used for parameter estimation. The model discrimination is based on the four criteria, namely sum of square errors, Fisher criterion, Akaike information criterion and minimum description length criterion. The most suitable model is identified that reflects the state variables curves adequately by considering acetate inhibited growth according to the Jerusalimsky approach. |
| first_indexed | 2024-04-12T20:16:02Z |
| format | Article |
| id | doaj.art-6f1f3f4ae0b24d47a4a632dbdc6becdc |
| institution | Directory Open Access Journal |
| issn | 1313-261X 1312-451X |
| language | English |
| last_indexed | 2024-04-12T20:16:02Z |
| publishDate | 2006-04-01 |
| publisher | Academic Publishing House |
| record_format | Article |
| series | Bioautomation |
| spelling | doaj.art-6f1f3f4ae0b24d47a4a632dbdc6becdc2022-12-22T03:18:08ZengAcademic Publishing HouseBioautomation1313-261X1312-451X2006-04-0141111Modelling of Escherichia coli Cultivations: Acetate Inhibition in a Fed-batch CultureStoyan TzonkovOlympia RoevaA set of three competing, unstructured models has been proposed to model biomass growth, glucose utilization, acetate formation, dissolved oxygen consumption and carbon dioxide accumulation of a fed-batch cultivation process of Escherichia coli. The inhibiting effect of acetate on growth of E. coli cultures is included in the considered models. The model identification is carried out using experimental data from the cultivation process. Genetic algorithms are used for parameter estimation. The model discrimination is based on the four criteria, namely sum of square errors, Fisher criterion, Akaike information criterion and minimum description length criterion. The most suitable model is identified that reflects the state variables curves adequately by considering acetate inhibited growth according to the Jerusalimsky approach.http://www.clbme.bas.bg/bioautomation/2006/vol_4.1/files/4_1.1.pdf ModellingEscherichia coliAcetate inhibitionParameter estimation |
| spellingShingle | Stoyan Tzonkov Olympia Roeva Modelling of Escherichia coli Cultivations: Acetate Inhibition in a Fed-batch Culture Bioautomation Modelling Escherichia coli Acetate inhibition Parameter estimation |
| title | Modelling of Escherichia coli Cultivations: Acetate Inhibition in a Fed-batch Culture |
| title_full | Modelling of Escherichia coli Cultivations: Acetate Inhibition in a Fed-batch Culture |
| title_fullStr | Modelling of Escherichia coli Cultivations: Acetate Inhibition in a Fed-batch Culture |
| title_full_unstemmed | Modelling of Escherichia coli Cultivations: Acetate Inhibition in a Fed-batch Culture |
| title_short | Modelling of Escherichia coli Cultivations: Acetate Inhibition in a Fed-batch Culture |
| title_sort | modelling of escherichia coli cultivations acetate inhibition in a fed batch culture |
| topic | Modelling Escherichia coli Acetate inhibition Parameter estimation |
| url | http://www.clbme.bas.bg/bioautomation/2006/vol_4.1/files/4_1.1.pdf |
| work_keys_str_mv | AT stoyantzonkov modellingofescherichiacolicultivationsacetateinhibitioninafedbatchculture AT olympiaroeva modellingofescherichiacolicultivationsacetateinhibitioninafedbatchculture |