Echinophorin D a new polyacetylene from an edible plant, Echinophora platyloba aerial parts
Background and objectives: The aerial parts of Echinophora platyloba are added to cheese and yoghurt for flavoring. Besides, it is used for the treatment of flatulence and as air freshener. Despite several pharmacological studies on the plant, no attempt has been made to isolate non-volatile seconda...
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| Format: | Article |
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Iranian Society of Pharmacognosy
2017-11-01
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| Series: | Research Journal of Pharmacognosy |
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| Online Access: | http://www.rjpharmacognosy.ir/article_53095_9db57d90feb1a76306bd79bec868ef26.pdf |
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| author | Z. Mohammadi L. Bazvandi F. Jafari N. Ghiasvand Y. Shokoohinia* |
| author_facet | Z. Mohammadi L. Bazvandi F. Jafari N. Ghiasvand Y. Shokoohinia* |
| author_sort | Z. Mohammadi |
| collection | DOAJ |
| description | Background and objectives: The aerial parts of Echinophora platyloba are added to cheese and yoghurt for flavoring. Besides, it is used for the treatment of flatulence and as air freshener. Despite several pharmacological studies on the plant, no attempt has been made to isolate non-volatile secondary metabolites from this plant. So, phytochemical investigation seems to be useful for better use of this plant in and to discover new compounds. Methods: Powdered aerial parts of the plant were extracted by Soxhlet apparatus with hexane, dichloromethane (DCM) and acetone. The concentrated acetone extract was fractionated using silica open column and mixture of heptane and ethyl acetate while DCM extract was fractionated by reverse phase column chromatography on RP-18 sorbent using mixture of methanol and water as solvent system with decreasing polarity. All subfractions were analysed by 1H- NMR, COSY, HSQC, HMBC and 13C-NMR. Results: After column chromatography and HPLC purification of DCM extract one new polyacetylene compound called echinophorin D was obtained and one fatty acid (coriolic acid) and one esteric polyacetylene (echinophorin B) were isolated and identified from the acetone extract. Conclusion: Due to the isolation of coriolic acid for the first time from this genus and the role of this fatty acid in inflammatory processes and anticancer activity as well as isolating polyacetylene compounds which have antioxidant and anti-tomur activity, this plant can be used as a source for compounds with antioxidant and anticancer effects. |
| first_indexed | 2024-12-17T07:16:14Z |
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| id | doaj.art-6f1f843ba9564c898861cf84d928d07a |
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| issn | 2345-4458 2345-5977 |
| language | English |
| last_indexed | 2024-12-17T07:16:14Z |
| publishDate | 2017-11-01 |
| publisher | Iranian Society of Pharmacognosy |
| record_format | Article |
| series | Research Journal of Pharmacognosy |
| spelling | doaj.art-6f1f843ba9564c898861cf84d928d07a2022-12-21T21:58:54ZengIranian Society of PharmacognosyResearch Journal of Pharmacognosy2345-44582345-59772017-11-014Supplement252553095Echinophorin D a new polyacetylene from an edible plant, Echinophora platyloba aerial partsZ. Mohammadi0L. Bazvandi1F. Jafari2N. Ghiasvand3Y. Shokoohinia*4Student Research Committee, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.Student Research Committee, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.Background and objectives: The aerial parts of Echinophora platyloba are added to cheese and yoghurt for flavoring. Besides, it is used for the treatment of flatulence and as air freshener. Despite several pharmacological studies on the plant, no attempt has been made to isolate non-volatile secondary metabolites from this plant. So, phytochemical investigation seems to be useful for better use of this plant in and to discover new compounds. Methods: Powdered aerial parts of the plant were extracted by Soxhlet apparatus with hexane, dichloromethane (DCM) and acetone. The concentrated acetone extract was fractionated using silica open column and mixture of heptane and ethyl acetate while DCM extract was fractionated by reverse phase column chromatography on RP-18 sorbent using mixture of methanol and water as solvent system with decreasing polarity. All subfractions were analysed by 1H- NMR, COSY, HSQC, HMBC and 13C-NMR. Results: After column chromatography and HPLC purification of DCM extract one new polyacetylene compound called echinophorin D was obtained and one fatty acid (coriolic acid) and one esteric polyacetylene (echinophorin B) were isolated and identified from the acetone extract. Conclusion: Due to the isolation of coriolic acid for the first time from this genus and the role of this fatty acid in inflammatory processes and anticancer activity as well as isolating polyacetylene compounds which have antioxidant and anti-tomur activity, this plant can be used as a source for compounds with antioxidant and anticancer effects.http://www.rjpharmacognosy.ir/article_53095_9db57d90feb1a76306bd79bec868ef26.pdfacetone extractcoriolic acidEchinophora platylobaechinophorin Bpolyacetylene |
| spellingShingle | Z. Mohammadi L. Bazvandi F. Jafari N. Ghiasvand Y. Shokoohinia* Echinophorin D a new polyacetylene from an edible plant, Echinophora platyloba aerial parts Research Journal of Pharmacognosy acetone extract coriolic acid Echinophora platyloba echinophorin B polyacetylene |
| title | Echinophorin D a new polyacetylene from an edible plant, Echinophora platyloba aerial parts |
| title_full | Echinophorin D a new polyacetylene from an edible plant, Echinophora platyloba aerial parts |
| title_fullStr | Echinophorin D a new polyacetylene from an edible plant, Echinophora platyloba aerial parts |
| title_full_unstemmed | Echinophorin D a new polyacetylene from an edible plant, Echinophora platyloba aerial parts |
| title_short | Echinophorin D a new polyacetylene from an edible plant, Echinophora platyloba aerial parts |
| title_sort | echinophorin d a new polyacetylene from an edible plant echinophora platyloba aerial parts |
| topic | acetone extract coriolic acid Echinophora platyloba echinophorin B polyacetylene |
| url | http://www.rjpharmacognosy.ir/article_53095_9db57d90feb1a76306bd79bec868ef26.pdf |
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