Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review
IntroductionIncreased abdominal visceral adipose tissue (VAT) implies an adverse cardio-metabolic profile. We examined the association of abdominal VAT parameters and all-cause mortality risk.MethodsWe systematically searched four databases. We performed citations/articles screening, data abstractio...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.922931/full |
| _version_ | 1818000379674099712 |
|---|---|
| author | Randa K. Saad Randa K. Saad Malak Ghezzawi Renee Horanieh Assem M. Khamis Katherine H. Saunders John A. Batsis Marlene Chakhtoura Marlene Chakhtoura |
| author_facet | Randa K. Saad Randa K. Saad Malak Ghezzawi Renee Horanieh Assem M. Khamis Katherine H. Saunders John A. Batsis Marlene Chakhtoura Marlene Chakhtoura |
| author_sort | Randa K. Saad |
| collection | DOAJ |
| description | IntroductionIncreased abdominal visceral adipose tissue (VAT) implies an adverse cardio-metabolic profile. We examined the association of abdominal VAT parameters and all-cause mortality risk.MethodsWe systematically searched four databases. We performed citations/articles screening, data abstraction, and quality assessment in duplicate and independently (CRD42020205021).ResultsWe included 12 cohorts, the majority used computed tomography to assess abdominal VAT area. Six cohorts with a mean age ≤ 65 years, examining all-cause mortality risk per increment in VAT area (cm2) or volume (cm3), showed a 11-98% relative risk increase with higher VAT parameters. However, the association lost significance after adjusting for glycemic indices, body mass index, or other fat parameters. In 4 cohorts with a mean age >65 years, the findings on mortality were inconsistent. Conversely, in two cohorts (mean age 73-77 years), a higher VAT density, was inversely proportional to VAT area, and implied a higher mortality risk.ConclusionA high abdominal VAT area seems to be associated with increased all-cause mortality in individuals ≤ 65 years, possibly mediated by metabolic complications, and not through an independent effect. This relationship is weaker and may reverse in older individuals, most likely secondary to confounding bias and reverse causality. An individual participant data meta-analysis is needed to confirm our findings, and to define an abdominal VAT area cutoff implying increased mortality risk.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=205021, identifier CRD42020205021. |
| first_indexed | 2024-04-14T03:20:51Z |
| format | Article |
| id | doaj.art-6f1fa5a8d8ab43dba43f8b20fe61837d |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-14T03:20:51Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-6f1fa5a8d8ab43dba43f8b20fe61837d2022-12-22T02:15:18ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-08-011310.3389/fendo.2022.922931922931Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic ReviewRanda K. Saad0Randa K. Saad1Malak Ghezzawi2Renee Horanieh3Assem M. Khamis4Katherine H. Saunders5John A. Batsis6Marlene Chakhtoura7Marlene Chakhtoura8Calcium Metabolism and Osteoporosis Program, World Health Organization (WHO) Collaborating Center for Metabolic Bone Disorders, Division of Endocrinology and Metabolism, Department of Internal Medicine - American University of Beirut Medical Center, Beirut, LebanonDepartement of Internal Medicine, American University of Beirut Medical Center, Beirut, LebanonDepartement of Internal Medicine, American University of Beirut Medical Center, Beirut, LebanonDepartement of Internal Medicine, American University of Beirut Medical Center, Beirut, LebanonWolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Hull, United KingdomDivision of Endocrinology, Diabetes & Metabolism, Weill Cornell Medicine, New York, NY, United StatesDivision of Geriatric Medicine and Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesCalcium Metabolism and Osteoporosis Program, World Health Organization (WHO) Collaborating Center for Metabolic Bone Disorders, Division of Endocrinology and Metabolism, Department of Internal Medicine - American University of Beirut Medical Center, Beirut, LebanonDepartement of Internal Medicine, American University of Beirut Medical Center, Beirut, LebanonIntroductionIncreased abdominal visceral adipose tissue (VAT) implies an adverse cardio-metabolic profile. We examined the association of abdominal VAT parameters and all-cause mortality risk.MethodsWe systematically searched four databases. We performed citations/articles screening, data abstraction, and quality assessment in duplicate and independently (CRD42020205021).ResultsWe included 12 cohorts, the majority used computed tomography to assess abdominal VAT area. Six cohorts with a mean age ≤ 65 years, examining all-cause mortality risk per increment in VAT area (cm2) or volume (cm3), showed a 11-98% relative risk increase with higher VAT parameters. However, the association lost significance after adjusting for glycemic indices, body mass index, or other fat parameters. In 4 cohorts with a mean age >65 years, the findings on mortality were inconsistent. Conversely, in two cohorts (mean age 73-77 years), a higher VAT density, was inversely proportional to VAT area, and implied a higher mortality risk.ConclusionA high abdominal VAT area seems to be associated with increased all-cause mortality in individuals ≤ 65 years, possibly mediated by metabolic complications, and not through an independent effect. This relationship is weaker and may reverse in older individuals, most likely secondary to confounding bias and reverse causality. An individual participant data meta-analysis is needed to confirm our findings, and to define an abdominal VAT area cutoff implying increased mortality risk.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=205021, identifier CRD42020205021.https://www.frontiersin.org/articles/10.3389/fendo.2022.922931/fullsystematic reviewvisceral adipose tissueabdominal visceral fatfatal outcomeall-cause mortality |
| spellingShingle | Randa K. Saad Randa K. Saad Malak Ghezzawi Renee Horanieh Assem M. Khamis Katherine H. Saunders John A. Batsis Marlene Chakhtoura Marlene Chakhtoura Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review Frontiers in Endocrinology systematic review visceral adipose tissue abdominal visceral fat fatal outcome all-cause mortality |
| title | Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review |
| title_full | Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review |
| title_fullStr | Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review |
| title_full_unstemmed | Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review |
| title_short | Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review |
| title_sort | abdominal visceral adipose tissue and all cause mortality a systematic review |
| topic | systematic review visceral adipose tissue abdominal visceral fat fatal outcome all-cause mortality |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.922931/full |
| work_keys_str_mv | AT randaksaad abdominalvisceraladiposetissueandallcausemortalityasystematicreview AT randaksaad abdominalvisceraladiposetissueandallcausemortalityasystematicreview AT malakghezzawi abdominalvisceraladiposetissueandallcausemortalityasystematicreview AT reneehoranieh abdominalvisceraladiposetissueandallcausemortalityasystematicreview AT assemmkhamis abdominalvisceraladiposetissueandallcausemortalityasystematicreview AT katherinehsaunders abdominalvisceraladiposetissueandallcausemortalityasystematicreview AT johnabatsis abdominalvisceraladiposetissueandallcausemortalityasystematicreview AT marlenechakhtoura abdominalvisceraladiposetissueandallcausemortalityasystematicreview AT marlenechakhtoura abdominalvisceraladiposetissueandallcausemortalityasystematicreview |