Osteoconductivity of Bovine Xenograft Granules of Different Sizes in Sinus Lift: A Histomorphometric Study in Rabbits
Background: Due to the lack of data on bone-to-graft contact (BGC) over time in the various regions within the subantral space of the augmented sinus floor, the present study aimed to evaluate the osteoconductivity of deproteinized bovine bone mineral (DBBM) with granules of different sizes applied...
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| Format: | Article |
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MDPI AG
2021-05-01
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| Series: | Dentistry Journal |
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| Online Access: | https://www.mdpi.com/2304-6767/9/6/61 |
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| author | Eduardo Pires Godoy Karol Alí Apaza Alccayhuaman Daniele Botticelli Andrea Amaroli Vitor Ferreira Balan Erick Ricardo Silva Samuel Porfirio Xavier |
| author_facet | Eduardo Pires Godoy Karol Alí Apaza Alccayhuaman Daniele Botticelli Andrea Amaroli Vitor Ferreira Balan Erick Ricardo Silva Samuel Porfirio Xavier |
| author_sort | Eduardo Pires Godoy |
| collection | DOAJ |
| description | Background: Due to the lack of data on bone-to-graft contact (BGC) over time in the various regions within the subantral space of the augmented sinus floor, the present study aimed to evaluate the osteoconductivity of deproteinized bovine bone mineral (DBBM) with granules of different sizes applied in maxillary sinus floor elevation. Methods: A maxillary sinus augmentation was performed bilaterally in 18 rabbits using DBBM with particle dimensions of either 0.125–1.0 mm or 1–2 mm. The antrostomy was covered using a collagen barrier. The animals were euthanized in groups of six after 2, 4, and 8 weeks of healing. MicroCT and histological analyses were performed. Results: After 2 weeks of healing, BGC was 10.9% and 11.9% for the small and large granule sites, respectively. After 8 weeks of healing, the BGC increased to 65% and 62% at the small and large granule sites, respectively. The highest values were located close to the bony walls and the bony window. New bone content developed between 2 and 8 weeks from 7.0% to 27.6% and from 6.1% to 27.6% at the small and large granule sites, respectively. Conclusions: Similar outcomes in osteoconductivity and bone formation were found at both small and large DBBM granule sites. |
| first_indexed | 2024-03-10T10:51:40Z |
| format | Article |
| id | doaj.art-6f1fe2025dba40f0b27428e359c330ff |
| institution | Directory Open Access Journal |
| issn | 2304-6767 |
| language | English |
| last_indexed | 2024-03-10T10:51:40Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj.art-6f1fe2025dba40f0b27428e359c330ff2023-11-21T22:09:47ZengMDPI AGDentistry Journal2304-67672021-05-01966110.3390/dj9060061Osteoconductivity of Bovine Xenograft Granules of Different Sizes in Sinus Lift: A Histomorphometric Study in RabbitsEduardo Pires Godoy0Karol Alí Apaza Alccayhuaman1Daniele Botticelli2Andrea Amaroli3Vitor Ferreira Balan4Erick Ricardo Silva5Samuel Porfirio Xavier6Department of Oral Biology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 14040-904, BrazilDepartment of Oral Biology, Medical University of Vienna, 1090 Vienna, AustriaARDEC Academy, 47923 Rimini, ItalyDepartment of Orthopaedic Dentistry, Faculty of Dentistry, First Moscow State Medical University (Sechenov University), 119991 Moscow, RussiaDepartment of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 14040-904, BrazilDepartment of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 14040-904, BrazilDepartment of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 14040-904, BrazilBackground: Due to the lack of data on bone-to-graft contact (BGC) over time in the various regions within the subantral space of the augmented sinus floor, the present study aimed to evaluate the osteoconductivity of deproteinized bovine bone mineral (DBBM) with granules of different sizes applied in maxillary sinus floor elevation. Methods: A maxillary sinus augmentation was performed bilaterally in 18 rabbits using DBBM with particle dimensions of either 0.125–1.0 mm or 1–2 mm. The antrostomy was covered using a collagen barrier. The animals were euthanized in groups of six after 2, 4, and 8 weeks of healing. MicroCT and histological analyses were performed. Results: After 2 weeks of healing, BGC was 10.9% and 11.9% for the small and large granule sites, respectively. After 8 weeks of healing, the BGC increased to 65% and 62% at the small and large granule sites, respectively. The highest values were located close to the bony walls and the bony window. New bone content developed between 2 and 8 weeks from 7.0% to 27.6% and from 6.1% to 27.6% at the small and large granule sites, respectively. Conclusions: Similar outcomes in osteoconductivity and bone formation were found at both small and large DBBM granule sites.https://www.mdpi.com/2304-6767/9/6/61animal studysinus floor elevationbone healingosteoconductivityhistologymorphometry |
| spellingShingle | Eduardo Pires Godoy Karol Alí Apaza Alccayhuaman Daniele Botticelli Andrea Amaroli Vitor Ferreira Balan Erick Ricardo Silva Samuel Porfirio Xavier Osteoconductivity of Bovine Xenograft Granules of Different Sizes in Sinus Lift: A Histomorphometric Study in Rabbits Dentistry Journal animal study sinus floor elevation bone healing osteoconductivity histology morphometry |
| title | Osteoconductivity of Bovine Xenograft Granules of Different Sizes in Sinus Lift: A Histomorphometric Study in Rabbits |
| title_full | Osteoconductivity of Bovine Xenograft Granules of Different Sizes in Sinus Lift: A Histomorphometric Study in Rabbits |
| title_fullStr | Osteoconductivity of Bovine Xenograft Granules of Different Sizes in Sinus Lift: A Histomorphometric Study in Rabbits |
| title_full_unstemmed | Osteoconductivity of Bovine Xenograft Granules of Different Sizes in Sinus Lift: A Histomorphometric Study in Rabbits |
| title_short | Osteoconductivity of Bovine Xenograft Granules of Different Sizes in Sinus Lift: A Histomorphometric Study in Rabbits |
| title_sort | osteoconductivity of bovine xenograft granules of different sizes in sinus lift a histomorphometric study in rabbits |
| topic | animal study sinus floor elevation bone healing osteoconductivity histology morphometry |
| url | https://www.mdpi.com/2304-6767/9/6/61 |
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