Heparanase induces necroptosis of microvascular endothelial cells to promote the metastasis of hepatocellular carcinoma

Heparanase induces necroptosis of microvascular endothelial cells to promote the metastasis of hepatocellular carcinoma

Abstract Heparanase (HPSE) is a kind of multifunctional extracellular hydrolase, and related to metastasis of hepatocellular carcinoma (HCC). Endothelial necroptosis promotes the metastasis of cancer cells. It is not clear whether HPSE could mediate necroptosis of microvascular endothelial cells (MV...

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Bibliographic Details
Main Authors: Xiaopeng Chen, Bin Cheng, Dafei Dai, Yuhai Wu, Zhiwen Feng, Chaogang Tong, Xiangming Wang, Jun Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00411-5

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