The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia

The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia

<p>Abstract</p> <p>Background</p> <p>The protein alpha-synuclein (α-SYN), which is found in the Lewy bodies of dopamine-producing (DA) neurons in the substantia nigra (SN), has an important role in the pathogenesis of Parkinson’s disease (PD). Previous studies have show...

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Bibliographic Details
Main Authors: Cao Shuwen, Standaert David G, Harms Ashley S
Format: Article
Language:English
Published: BMC 2012-11-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
FcγR
NF-κB
Microglia
Online Access:http://www.jneuroinflammation.com/content/9/1/259

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