Vitamin D and Infertility: The Evidence
Vitamin D is a lipid soluble vitamin synthesized by the skin upon exposure to UV light. Approximately 10–20% of vitamin D comes from dietary sources and 25OH-D is its circulating form. Vitamin D receptors are found in reproductive tissues including ovary, uterus, and endometrium permitting investiga...
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2019-03-01
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| Series: | Fertility & Reproduction |
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| Online Access: | http://www.worldscientific.com/doi/epdf/10.1142/S266131821950004X |
| _version_ | 1828964987014479872 |
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| author | Mark D. Hornstein |
| author_facet | Mark D. Hornstein |
| author_sort | Mark D. Hornstein |
| collection | DOAJ |
| description | Vitamin D is a lipid soluble vitamin synthesized by the skin upon exposure to UV light. Approximately 10–20% of vitamin D comes from dietary sources and 25OH-D is its circulating form. Vitamin D receptors are found in reproductive tissues including ovary, uterus, and endometrium permitting investigators to hypothesize a role for vitamin D in reproduction. Indeed, a number of animal studies provide evidence of vitamin D’s importance in fertility. Studies in humans, however, generally have not supported an effect of vitamin D on fertility outcomes. Several retrospective cohort studies did not demonstrate an association between vitamin D levels and pregnancy. Similarly, one study did not find correlation between anovulatory infertility and vitamin D intake. Very low levels of vitamin D, however, were associated with miscarriage in another study. A large meta-analysis of 11 studies and 2700 women did show an improvement in IVF success rates in those with higher levels of vitamin D. Finally, two small studies on vitamin D supplementation and pregnancy did not show a benefit of increasing vitamin D intake. In conclusion, the literature at best shows a minimal impact of vitamin D on infertility and IVF outcomes. |
| first_indexed | 2024-12-14T11:01:35Z |
| format | Article |
| id | doaj.art-6f21404d1d1b435099aa6872f86fd33a |
| institution | Directory Open Access Journal |
| issn | 2661-3182 2661-3174 |
| language | English |
| last_indexed | 2024-12-14T11:01:35Z |
| publishDate | 2019-03-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Fertility & Reproduction |
| spelling | doaj.art-6f21404d1d1b435099aa6872f86fd33a2022-12-21T23:04:43ZengWorld Scientific PublishingFertility & Reproduction2661-31822661-31742019-03-0111313310.1142/S266131821950004X10.1142/S266131821950004XVitamin D and Infertility: The EvidenceMark D. Hornstein0Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAVitamin D is a lipid soluble vitamin synthesized by the skin upon exposure to UV light. Approximately 10–20% of vitamin D comes from dietary sources and 25OH-D is its circulating form. Vitamin D receptors are found in reproductive tissues including ovary, uterus, and endometrium permitting investigators to hypothesize a role for vitamin D in reproduction. Indeed, a number of animal studies provide evidence of vitamin D’s importance in fertility. Studies in humans, however, generally have not supported an effect of vitamin D on fertility outcomes. Several retrospective cohort studies did not demonstrate an association between vitamin D levels and pregnancy. Similarly, one study did not find correlation between anovulatory infertility and vitamin D intake. Very low levels of vitamin D, however, were associated with miscarriage in another study. A large meta-analysis of 11 studies and 2700 women did show an improvement in IVF success rates in those with higher levels of vitamin D. Finally, two small studies on vitamin D supplementation and pregnancy did not show a benefit of increasing vitamin D intake. In conclusion, the literature at best shows a minimal impact of vitamin D on infertility and IVF outcomes.http://www.worldscientific.com/doi/epdf/10.1142/S266131821950004Xvitamin dinfertilityin vitro fertilizationassisted reproductive technologies |
| spellingShingle | Mark D. Hornstein Vitamin D and Infertility: The Evidence Fertility & Reproduction vitamin d infertility in vitro fertilization assisted reproductive technologies |
| title | Vitamin D and Infertility: The Evidence |
| title_full | Vitamin D and Infertility: The Evidence |
| title_fullStr | Vitamin D and Infertility: The Evidence |
| title_full_unstemmed | Vitamin D and Infertility: The Evidence |
| title_short | Vitamin D and Infertility: The Evidence |
| title_sort | vitamin d and infertility the evidence |
| topic | vitamin d infertility in vitro fertilization assisted reproductive technologies |
| url | http://www.worldscientific.com/doi/epdf/10.1142/S266131821950004X |
| work_keys_str_mv | AT markdhornstein vitamindandinfertilitytheevidence |